Continuous and simultaneous measurement of the biophysical properties of blood in a microfluidic environment

The Analyst ◽  
2016 ◽  
Vol 141 (24) ◽  
pp. 6583-6597 ◽  
Author(s):  
Yang Jun Kang
Keyword(s):  
Blood Viscosity ◽  
Simultaneous Measurement ◽  
Measurement Method ◽  
Biophysical Properties ◽  
Rbc Aggregation

A new measurement method is proposed to quantify blood viscosity, blood viscoelasticity, and RBC aggregation, in a continuous and simultaneous fashion.

scholarly journals Quantitative Monitoring of Dynamic Blood Flows Using Coflowing Laminar Streams in a Sensorless Approach

2021 ◽  
Vol 11 (16) ◽  
pp. 7260
Author(s):  
Yang Jun Kang
Keyword(s):  
Blood Flow ◽  
Flow Rate ◽  
Blood Viscosity ◽  
Measurement Errors ◽  
Present Method ◽  
Test Fluid ◽  
Constant Flow Rate ◽  
Rbc Aggregation ◽  
Sinusoidal Flow ◽  
Analytical Expressions

Determination of blood viscosity requires consistent measurement of blood flow rates, which leads to measurement errors and presents several issues when there are continuous changes in hematocrit changes. Instead of blood viscosity, a coflowing channel as a pressure sensor is adopted to quantify the dynamic flow of blood. Information on blood (i.e., hematocrit, flow rate, and viscosity) is not provided in advance. Using a discrete circuit model for the coflowing streams, the analytical expressions for four properties (i.e., pressure, shear stress, and two types of work) are then derived to quantify the flow of the test fluid. The analytical expressions are validated through numerical simulations. To demonstrate the method, the four properties are obtained using the present method by varying the flow patterns (i.e., constant flow rate or sinusoidal flow rate) as well as test fluids (i.e., glycerin solutions and blood). Thereafter, the present method is applied to quantify the dynamic flows of RBC aggregation-enhanced blood with a peristaltic pump, where any information regarding the blood is not specific. The experimental results indicate that the present method can quantify dynamic blood flow consistently, where hematocrit changes continuously over time.

A physiometer for simultaneous measurement of whole blood viscosity and its determinants: hematocrit and red blood cell deformability

The Analyst ◽  
2019 ◽  
Vol 144 (9) ◽  
pp. 3144-3157 ◽  
Author(s):  
Byung Jun Kim ◽  
Ye Sung Lee ◽  
Alexander Zhbanov ◽  
Sung Yang
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Blood Viscosity ◽  
Simultaneous Measurement ◽  
Whole Blood ◽  
Cell Deformability ◽  
Whole Blood Viscosity ◽  
Red Blood Cell Deformability ◽  
Rbc Deformability

In this study, a microfluidic-based physiometer capable of measuring the whole blood viscosity, hematocrit, and red blood cell (RBC) deformability on a chip is introduced.

A novel simultaneous measurement method to assess the influence of intracerebroventricular obestatin on colonic motility and secretion in conscious rats

Peptides ◽  
2010 ◽  
Vol 31 (6) ◽  
pp. 1113-1117 ◽  
Author(s):  
Chih-Yen Chen ◽  
Ming-Luen Doong ◽  
Chung-Pin Li ◽  
Wen-Jinn Liaw ◽  
Hsing-Feng Lee ◽  
...  
Keyword(s):  
Simultaneous Measurement ◽  
Measurement Method ◽  
Colonic Motility ◽  
Conscious Rats

scholarly journals N-Acetylneuraminic Acid Deficiency in Erythrocyte Membranes: Biophysical and Biochemical Correlates

Blood ◽  
1974 ◽  
Vol 43 (3) ◽  
pp. 445-460 ◽  
Author(s):  
Shu Chien ◽  
George W. Cooper ◽  
Kung-ming Jan ◽  
Louis H. Miller ◽  
Calderon Howe ◽  
...  
Keyword(s):  
Surface Charge ◽  
Blood Viscosity ◽  
Experimental Studies ◽  
Cell Aggregation ◽  
Small Population ◽  
Erythrocyte Membranes ◽  
Normal Surface ◽  
Clinical Patient ◽  
Acetylneuraminic Acid ◽  
Rbc Aggregation

Abstract The electrochemical and rheologic behaviors of red blood cells (RBCs) from a patient with acquired polyagglutinability were studied. The N-acetylneuraminic acid content of the RBCs averaged less than one-half normal. The majority of the patient’s RBCs (over 90%) showed a reduction in electrophoretic mobility and a decrease in binding of positively charged colloid with a widening of the charge-free areas, but a small population exhibited normal surface charge density. Dextran 40, which does not induce significant aggregation of normal RBCs, caused the patient’s RBCs to form rouleaux. Dextran 80 induced a stronger aggregation of the patient’s RBCs than that of normal RBCs. The increased tendency of the patient’s RBCs to be aggregated by macromolecules was associated with an elevation of blood viscosity. This study on a clinical patient has provided evidence for the conclusions previously derived from experimental studies that the stability of RBC aggregation depends upon a balance between macromolecular bridging force and electrostatic repulsive force and that alterations in RBC surface charge may affect cell aggregation and blood viscosity.

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