scholarly journals Microfluidic array for simultaneous detection of DNA oxidation and DNA-adduct damage

The Analyst ◽  
2016 ◽  
Vol 141 (20) ◽  
pp. 5722-5729 ◽  
Author(s):  
Boya Song ◽  
Min Shen ◽  
Di Jiang ◽  
Spundana Malla ◽  
Islam M. Mosa ◽  
...  
Keyword(s):  
Electrochemical Sensor ◽  
Sensor Array ◽  
Simultaneous Detection ◽  
Adduct Formation ◽  
Dna Oxidation ◽  
Dna Adduct

A microfluidic electrochemical sensor array detects DNA oxidation and adduct formation for a fast genotoxicity chemistry screen for test compounds.

scholarly journals MnO2@Reduced Graphene Oxide Nanocomposite-Based Electrochemical Sensor for the Simultaneous Determination of Trace Cd(II), Zn(II) and Cu(II) in Water Samples

Membranes ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 517
Author(s):  
Siyamthanda Hope Mnyipika ◽  
Tshimangadzo Saddam Munonde ◽  
Philiswa Nosizo Nomngongo
Keyword(s):  
Heavy Metals ◽  
Electrochemical Sensor ◽  
Simultaneous Determination ◽  
Rapid Detection ◽  
Electrochemical Sensors ◽  
Simultaneous Detection ◽  
Cyclic Voltammograms ◽  
Current Response ◽  
Mno2 Nanoparticles

The rapid detection of trace metals is one of the most important aspect in achieving environmental monitoring and protection. Electrochemical sensors remain a key solution for rapid detection of heavy metals in environmental water matrices. This paper reports the fabrication of an electrochemical sensor obtained by the simultaneous electrodeposition of MnO2 nanoparticles and RGO nanosheets on the surface of a glassy carbon electrode. The successful electrodeposition was confirmed by the enhanced current response on the cyclic voltammograms. The XRD, HR-SEM/EDX, TEM, FTIR, and BET characterization confirmed the successful synthesis of MnO2 nanoparticles, RGO nanosheets, and MnO2@RGO nanocomposite. The electrochemical studies results revealed that MnO2@RGO@GCE nanocomposite considerably improved the current response on the detection of Zn(II), Cd(II) and Cu(II) ions in surface water. These remarkable improvements were due to the interaction between MnO2 nanomaterials and RGO nanosheets. Moreover, the modified sensor electrode portrayed high sensitivity, reproducibility, and stability on the simultaneous determination of Zn(II), Cd(II), and Cu(II) ions. The detection limits of (S/N = 3) ranged from 0.002–0.015 μg L−1 for the simultaneous detection of Zn(II), Cd(II), and Cu(II) ions. The results show that MnO2@RGO nanocomposite can be successfully used for the early detection of heavy metals with higher sensitivity in water sample analysis.

Nitroreduction of 4-Nitropyrene Is Primarily Responsible for DNA Adduct Formation in the Mammary Gland of Female CD Rats

1999 ◽  
Vol 12 (2) ◽  
pp. 180-186 ◽  
Author(s):  
Young-Heum Chae ◽  
Ben-Yi Ji ◽  
Jyh-Ming Lin ◽  
Peter P. Fu ◽  
Bongsup P. Cho ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Adduct Formation ◽  
Dna Adduct

scholarly journals Ethanol and 4-methylpyrazole increase DNA adduct formation of furfuryl alcohol in FVB/N wild-type mice and in mice expressing human sulfotransferases 1A1/1A2

2016 ◽  
Vol 37 (3) ◽  
pp. 314-319 ◽  
Author(s):  
Benjamin Sachse ◽  
Walter Meinl ◽  
Hansruedi Glatt ◽  
Bernhard H. Monien
Keyword(s):  
Furfuryl Alcohol ◽  
Adduct Formation ◽  
Dna Adduct ◽  
Wild Type

scholarly journals Modulation of Carcinogen Metabolism by Nitric Oxide-Aspirin 2 Is Associated with Suppression of DNA Damage and DNA Adduct Formation

2009 ◽  
Vol 284 (33) ◽  
pp. 22099-22107 ◽  
Author(s):  
Christopher J. MacDonald ◽  
Robert Y. S. Cheng ◽  
David D. Roberts ◽  
David A. Wink ◽  
Grace Chao Yeh
Keyword(s):  
Nitric Oxide ◽  
Dna Damage ◽  
Adduct Formation ◽  
Dna Adduct ◽  
Carcinogen Metabolism

Action of vitamin A on DNA adduct formation by aflatoxin B1 in a microsome catalyzed reaction

1987 ◽  
Vol 34 (2) ◽  
pp. 213-220 ◽  
Author(s):  
P.F. Firozi ◽  
V.S. Aboobaker ◽  
R.K. Bhattacharya
Keyword(s):  
Vitamin A ◽  
Aflatoxin B1 ◽  
Adduct Formation ◽  
Dna Adduct
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