Recent topics on single-molecule fluctuation analysis using blinking in surface-enhanced resonance Raman scattering: clarification by the electromagnetic mechanism

The Analyst ◽  
2016 ◽  
Vol 141 (17) ◽  
pp. 5000-5009 ◽  
Author(s):  
Tamitake Itoh ◽  
Yuko S. Yamamoto
Keyword(s):  
Raman Scattering ◽  
Metal Nanoparticles ◽  
Single Molecule ◽  
Silver Nanoparticle ◽  
Carbon Clusters ◽  
Fluctuation Analysis ◽  
Resonance Raman Scattering ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

Fluctuating single sp2carbon clusters at single hotspots of silver nanoparticle dimers investigated by surface-enhanced Raman scattering (SERS), indicating that SERS has become an ultrasensitive tool for clarifying molecular functions on plasmonic metal nanoparticles (NPs).

scholarly journals Multiplexed Liquid Biopsy and Tumor Imaging Using Surface-Enhanced Raman Scattering

Biosensors ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 449
Author(s):  
Francesco Dell’Olio
Keyword(s):  
Raman Scattering ◽  
Single Molecule ◽  
Liquid Biopsy ◽  
Tumor Imaging ◽  
Surface Enhanced Raman Scattering ◽  
Detection Sensitivity ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

The recent improvements in diagnosis enabled by advances in liquid biopsy and oncological imaging significantly better cancer care. Both these complementary approaches, which are used for early tumor detection, characterization, and monitoring, can benefit from applying techniques based on surface-enhanced Raman scattering (SERS). With a detection sensitivity at the single-molecule level, SERS spectroscopy is widely used in cell and molecular biology, and its capability for the in vitro detection of several types of cancer biomarkers is well established. In the last few years, several intriguing SERS applications have emerged, including in vivo imaging for tumor targeting and the monitoring of drug release. In this paper, selected recent developments and trends in SERS applications in the field of liquid biopsy and tumor imaging are critically reviewed, with a special emphasis on results that demonstrate the clinical utility of SERS.

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