scholarly journals Glycan heterogeneity on gold nanoparticles increases lectin discrimination capacity in label-free multiplexed bioassays

The Analyst ◽  
2016 ◽  
Vol 141 (14) ◽  
pp. 4305-4312 ◽  
Author(s):  
Lucienne Otten ◽  
Denise Vlachou ◽  
Sarah-Jane Richards ◽  
Matthew I. Gibson
Keyword(s):  
Gold Nanoparticles ◽  
Infectious Diseases ◽  
Point Of Care ◽  
Biological Warfare ◽  
Drug Resistant ◽  
Label Free ◽  
Biological Warfare Agents ◽  
Warfare Agents ◽  
Glycan Heterogeneity ◽  
Analytical Tools

The development of new analytical tools as point-of-care biosensors is crucial to combat the spread of infectious diseases, especially in the context of drug-resistant organisms, or to detect biological warfare agents.

scholarly journals Antibodies and antibody-derived analytical biosensors

2016 ◽  
Vol 60 (1) ◽  
pp. 9-18 ◽  
Author(s):  
Shikha Sharma ◽  
Hannah Byrne ◽  
Richard J. O'Kennedy
Keyword(s):  
Illicit Drugs ◽  
Point Of Care ◽  
High Specificity ◽  
Biological Warfare ◽  
Rapid Diagnostics ◽  
Timely Initiation ◽  
Specificity And Sensitivity ◽  
Appropriate Treatment ◽  
Biological Warfare Agents ◽  
Warfare Agents

The rapid diagnosis of many diseases and timely initiation of appropriate treatment are critical determinants that promote optimal clinical outcomes and general public health. Biosensors are now being applied for rapid diagnostics due to their capacity for point-of-care use with minimum need for operator input. Antibody-based biosensors or immunosensors have revolutionized diagnostics for the detection of a plethora of analytes such as disease markers, food and environmental contaminants, biological warfare agents and illicit drugs. Antibodies are ideal biorecognition elements that provide sensors with high specificity and sensitivity. This review describes monoclonal and recombinant antibodies and different immobilization approaches crucial for antibody utilization in biosensors. Examples of applications of a variety of antibody-based sensor formats are also described.

scholarly journals Current Trends in the Biosensors for Biological Warfare Agents Assay

Materials ◽  
2019 ◽  
Vol 12 (14) ◽  
pp. 2303 ◽  
Author(s):  
Miroslav Pohanka
Keyword(s):  
Biological Warfare ◽  
Biological Origin ◽  
Current Trends ◽  
Biological Warfare Agents ◽  
Warfare Agents ◽  
Sensitivity And Selectivity ◽  
Physical Sensor ◽  
Analytical Tools ◽  
Laboratory Assay

Biosensors are analytical devices combining a physical sensor with a part of biological origin providing sensitivity and selectivity toward analyte. Biological warfare agents are infectious microorganisms or toxins with the capability to harm or kill humans. They can be produced and spread by a military or misused by a terrorist group. For example, Bacillus anthracis, Francisella tularensis, Brucella sp., Yersinia pestis, staphylococcal enterotoxin B, botulinum toxin and orthopoxviruses are typical biological warfare agents. Biosensors for biological warfare agents serve as simple but reliable analytical tools for the both field and laboratory assay. There are examples of commercially available biosensors, but research and development of new types continue and their application in praxis can be expected in the future. This review summarizes the facts and role of biosensors in the biological warfare agents’ assay, and shows current commercially available devices and trends in research of the news. Survey of actual literature is provided.

ENVIRONMENTAL SENSING OF CHEMICAL AND BIOLOGICAL WARFARE AGENTS IN THE THz REGION

2003 ◽  
Author(s):  
ALAN C. SAMUELS ◽  
DWIGHT L. WOOLARD ◽  
TATIANA GLOBUS ◽  
BORIS GELMONT ◽  
ELLIOTT R. BROWN ◽  
...  
Keyword(s):  
Biological Warfare ◽  
Environmental Sensing ◽  
Biological Warfare Agents ◽  
Warfare Agents
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