Fast solid-phase extraction of N-linked glycopeptides by amine-functionalized mesoporous silica nanoparticles

The Analyst ◽  
2016 ◽  
Vol 141 (8) ◽  
pp. 2435-2440 ◽  
Author(s):  
Weili Miao ◽  
Cheng Zhang ◽  
Yan Cai ◽  
Ying Zhang ◽  
Haojie Lu
Keyword(s):  
Mesoporous Material ◽  
Reductive Amination ◽  
Solid Phase ◽  
Mesoporous Silica Nanoparticles ◽  
Phase Extraction ◽  
Functionalized Mesoporous Silica ◽  
Amine Functionalized ◽  
Amination Reaction ◽  
First Time ◽  
Enrichment Efficiency

For the first time, mesoporous material has been introduced into N-glycoproteome extraction based on a reductive amination reaction, which greatly enhanced the enrichment efficiency and deglycosylation efficiency.

scholarly journals Separation and determination of lead in human urine and water samples based on thiol functionalized mesoporous silica nanoparticles packed on cartridges by micro column fast micro solid-phase extraction

2019 ◽  
pp. 39-50 ◽  
Author(s):  
Maling Gou ◽  
*Baharak Bahrami Yarahmadi
Keyword(s):  
Mesoporous Silica ◽  
Solid Phase Extraction ◽  
Silica Nanoparticles ◽  
Water Samples ◽  
Solid Phase ◽  
Mesoporous Silica Nanoparticles ◽  
Electrothermal Atomic Absorption Spectrometry ◽  
Cellulose Membrane ◽  
Phase Extraction ◽  
Functionalized Mesoporous Silica

An efficient method based on thiol functionalized mesoporous silica nanoparticles (HS-MSNPs) was used for extraction of lead ions (PbII) from urine and water samples by packed column micro solid phase extraction (PC-MSPE). By procedure, 15 mg of HS-MSNPs packed in syringe cartridges (SC, 5 mL) with cellulose membrane and pH adjusting at 5.5-6.5.  Then, the lead of urine and water sample was efficiently extracted on HS-MSNPs after pushing the plunger of a syringe. Finally, the Pb (II) was back-extracted with inorganic acid solution and the remained solution determined by electrothermal atomic absorption spectrometry (ET-AAS). By optimization conditions, the enrichment factor, LOD, linear range and RSD% was obtained 24.8, 0.04 μg L-1, 0.12-5.5 μg L-1 and less than 5%, respectively for 5 mL of urine samples. The validation was confirmed by spiking of real samples and using certified reference material (CRM, NIST) in water and urine sample.

Curcumin-Loaded Amine-Functionalized Mesoporous Silica Nanoparticles Inhibit α-Synuclein Fibrillation and Reduce Its Cytotoxicity-Associated Effects

Langmuir ◽  
2016 ◽  
Vol 32 (50) ◽  
pp. 13394-13402 ◽  
Author(s):  
Nayere Taebnia ◽  
Dina Morshedi ◽  
Soheila Yaghmaei ◽  
Farhang Aliakbari ◽  
Fatemeh Rahimi ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Functionalized Mesoporous Silica ◽  
Amine Functionalized

scholarly journals Isolation and Quantification of miRNA from the Biomolecular Corona on Mesoporous Silica Nanoparticles

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1196
Author(s):  
Carla Vidaurre-Agut ◽  
Eva María Rivero-Buceta ◽  
Christopher C. Landry ◽  
Pablo Botella
Keyword(s):  
Prostate Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Incubation Temperature ◽  
Mesoporous Silica Nanoparticles ◽  
Nanoparticle Concentration ◽  
Functionalized Mesoporous Silica ◽  
Amine Functionalized ◽  
Commercial Kit ◽  
Higher Sensitivity

To understand the factors that control the formation of the biomolecular corona, a systematic study of the adsorption of several miRNAs shown to be important in prostate cancer on amine-functionalized mesoporous silica nanoparticles (MSN-NH2) has been performed. Process parameters including miRNA type, nanoparticle concentration, incubation temperature and incubation time were investigated, as well as the potential competition for adsorption between different miRNA molecules. The influence of proteins and particle PEGylation on miRNA adsorption were also explored. We found that low particle concentrations and physiological temperature both led to increased miRNA adsorption. Adsorption of miRNA was also higher when proteins were present in the same solution; reducing or preventing protein adsorption by PEGylating the MSNs hindered adsorption. Finally, the amount of miRNA adsorbed from human serum by MSN-NH2 was compared to a commercial miRNA purification kit (TaqMan®, Life Technologies, Carlsbad, CA, USA). MSN-NH2 adsorbed six times as much miRNA as the commercial kit, demonstrating higher sensitivity to subtle up- and downregulation of circulating miRNA in the blood of patients.

scholarly journals Magnetic solid phase extraction with octahedral structured Fe3O4@SiO2@polydimethylsiloxane magnetic nanoparticles as the sorbent for determining benzene, toluene, ethylbenzene and xylenes in water samples

RSC Advances ◽  
2017 ◽  
Vol 7 (66) ◽  
pp. 41862-41868 ◽  
Author(s):  
Maosheng Zhang ◽  
Guobin Huang ◽  
Jiarong Huang ◽  
Ling Zhong ◽  
Weilan Chen
Keyword(s):  
Magnetic Nanoparticles ◽  
Solid Phase Extraction ◽  
Water Samples ◽  
Solid Phase ◽  
Magnetic Solid Phase Extraction ◽  
Phase Extraction ◽  
Benzene Toluene ◽  
Magnetic Solid ◽  
First Time

Novel octahedral structured Fe3O4@SiO2@polydimethylsiloxane magnetic nanoparticles (Fe3O4@SiO2@PDMS MNPs) have been successfully synthesized for the first time.

scholarly journals Surface adsorption of Nordic aquatic fulvic acid on amine-functionalized and non-functionalized mesoporous silica nanoparticles

2018 ◽  
Vol 5 (9) ◽  
pp. 2162-2171 ◽  
Author(s):  
Sanjaya Jayalath ◽  
Sarah C. Larsen ◽  
Vicki H. Grassian
Keyword(s):  
Organic Matter ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Fulvic Acid ◽  
Natural Organic Matter ◽  
Mesoporous Silica Nanoparticles ◽  
Surface Adsorption ◽  
Functionalized Mesoporous Silica ◽  
Amine Functionalized

Mesoporous silica nanoparticles (MSNs) have the potential to be released into the environment and to then adsorb natural organic matter.

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