scholarly journals Silver nanoparticles induced oxidative and endoplasmic reticulum stresses in mouse tissues: implications for the development of acute toxicity after intravenous administration

2016 ◽  
Vol 5 (2) ◽  
pp. 602-608 ◽  
Author(s):  
Rui Chen ◽  
Lin Zhao ◽  
Ru Bai ◽  
Ying Liu ◽  
Liping Han ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Endoplasmic Reticulum ◽  
Acute Toxicity ◽  
Intravenous Administration ◽  
Toxic Damage ◽  
Target Organs ◽  
Mouse Tissues

AgNPs cause toxic damage by gradually imposing stress impacts on the target organs in mice.

scholarly journals Size-dependent acute toxicity of silver nanoparticles in mice

2018 ◽  
Vol 31 (1) ◽  
pp. 73-80 ◽  
Author(s):  
Young-Man Cho ◽  
Yasuko Mizuta ◽  
Jun-ichi Akagi ◽  
Takeshi Toyoda ◽  
Mizuki Sone ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Acute Toxicity ◽  
Size Dependent

scholarly journals Assesment of 28 days repeated adminstration toxicity profile of dexamethasone palmitate injection

2015 ◽  
Vol 27 (1) ◽  
pp. 9-19 ◽  
Author(s):  
Ganesh N Sharma ◽  
Shaili Rasania ◽  
Paresh Dadhaniya ◽  
Chintan Patel ◽  
Kapil Vachhani
Keyword(s):  
Acute Toxicity ◽  
Intravenous Administration ◽  
Adverse Reactions ◽  
Reference Range ◽  
Range Limit ◽  
Experimental Animals ◽  
Dexamethasone Palmitate ◽  
Laboratory Reference ◽  
Dose Levels ◽  
Different Levels

Although, the dexamethasone have been used for the managements, against various ailments as single API or in combination with other drugs as acetate or palmitate salt. However, Dexamethasone as palmitate salt has not been investigated so far for sub acute toxicity on intravenous administration. Therefore, an attempt has been made to investigate sub-acute toxicity of dexamethasone palmitate injection. The drug was administered in experimental animals at different dose levels (0.07, 0.18 and 0.44 mg/kg, b.w.), for 28 days, and alteration in biochemical and haematological parameters was recorded along with histological examinations. The result data revealed that intravenous administration of dexamethasone palmitate does not causes any significant alteration in experimental animals examined at different levels. The observed changes were either well established adverse effects of Dexamethasone or were in laboratory reference range limit. The intravenous administered doses of drug were found safer, although somewhat adverse reactions may be observed at higher dose level (s). DOI: http://dx.doi.org/10.3126/jnpa.v27i1.12145 Journal of Nepal Pharmaceutical Association 2014 Vol.XXVII: 9-19

scholarly journals An Evaluation of Acute Toxicity of Colloidal Silver Nanoparticles

2011 ◽  
Vol 73 (11) ◽  
pp. 1417-1423 ◽  
Author(s):  
Pattwat MANEEWATTANAPINYO ◽  
Wijit BANLUNARA ◽  
Chuchaat THAMMACHAROEN ◽  
Sanong EKGASIT ◽  
Theerayuth KAEWAMATAWONG
Keyword(s):  
Silver Nanoparticles ◽  
Acute Toxicity ◽  
Colloidal Silver ◽  
Colloidal Silver Nanoparticles

scholarly journals Sunlight-Induced Synthesis of Non-Target Biosafety Silver Nanoparticles for the Control of Rice Bacterial Diseases

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 2007
Author(s):  
Hongyi Shang ◽  
Zehao Zhou ◽  
Xuemin Wu ◽  
Xuefeng Li ◽  
Yong Xu
Keyword(s):  
Silver Nanoparticles ◽  
Acute Toxicity ◽  
Laser Scanning ◽  
Control Plant ◽  
Confocal Laser Scanning Microscope ◽  
Confocal Laser ◽  
Bacterial Diseases ◽  
Rice Bacterial Blight ◽  
High Antibacterial Activity ◽  
Vis Spectroscopy

Silver is an important and efficient bactericide. Nanoscale silver has a large specific surface area, high target adhesion, strong permeability and high bactericidal activity. At present, the control of plant bacterial diseases is difficult, and the resistance of plant bacterial pathogens develops rapidly. Silver nanoparticles are expected to become a new generation of agrochemical to control plant bacterial diseases. In this study, a simple and green natural sunlight-induced method was used to prepare carboxymethylcellulose sodium-stabilized silver nanoparticles (CMC-SNs) with a particle size of around 13.53 ± 4.72 nm. CMC-SNs were characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), energy-dispersive spectrometry (EDS), X-ray diffraction (XRD) and UV-vis spectroscopy and found to be spherical and evenly dispersed. The bacteriostatic activity of the CMC-SNs toward Xanthomonas oryzae pv. oryzae (Xoo) was tested. The minimum inhibitory concentration (MIC) of CMC-SNs to Xoo was 1 mg/L, and the minimum bactericidal concentration (MBC) was 2 mg/L. In addition, the antibacterial mechanism was studied by scanning electron microscope (SEM) and confocal laser scanning microscope (CLSM), which confirmed that the CMC-SNs had high antibacterial activity. In order to verify its impact on the environment, we conducted an acute toxicity test on zebrafish and found that Half lethal concentration (LC50) > 100 mg/L in zebrafish, or no acute toxicity. The ability of CMC-SNs to control rice bacterial blight was verified by a pot experiment.

scholarly journals Acute Toxicity of Tomato Extract (Lycopersicum esculentum) on Rat’ Liver

2019 ◽  
Author(s):  
Retno Sri Iswari ◽  
Ari Yuniastuti ◽  
Talitha Widiatningrum
Keyword(s):  
Acute Toxicity ◽  
Traditional Medicine ◽  
Cell Structure ◽  
Toxic Effects ◽  
Control Group ◽  
Lycopersicum Esculentum ◽  
Sprague Dawley ◽  
Gamma Glutamyl Transpeptidase ◽  
Tomato Extract ◽  
Toxic Damage

Tomato extract (Lycopersicum esculentum) is commonly used as traditional medicine because of its antioxidant activity. As a traditional medicine, tomato extract uses for therapy. Therefore, it is important to note that the safety aspect does not cause toxic effects. This study aimed to determine the acute toxicity of tomato (Lycopersicum esculentum) extract on the liver of Sprague Dawley rats (SD) by looking at the activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alacaline phosphatase (ALP), gamma glutamyl transpeptidase (GTP) and features liver organ histopathology. Acute toxicity test was carried out by giving tomato extract orally in doses of 16, 160, 1600 and 16000 mg/ individual. Toxicity observations were carried out within 14 days after administration. The activities of AST, ALT, ALP and GGT were analyzed using Diasys kit for research purpose. The results showed that the activity of AST, ALT, ALP and GGT was not significantly different in the treatment group with the control group (p<0.05) and histopathology found some changes in cell structure and tissue in the liver organ but this change did not indicate the occurrence of toxic damage. The conclusion of this study is that no acute toxic effects were found from tomato extract (Lycopersicum esculentum) on SD rats.

scholarly journals Toxicity of leachates from pilot reactors simulating a landfill with different concentrations of AgNP

2019 ◽  
Vol 24 (6) ◽  
pp. 1089-1094
Author(s):  
Raphael Zanelato ◽  
Isabela da Cruz Bonatto ◽  
José Julio Barrios Restrepo ◽  
Rodrigo Costa Puerari ◽  
William Gerson Matias ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Acute Toxicity ◽  
Aquatic Ecosystems ◽  
Aquatic Invertebrates ◽  
Trophic Levels ◽  
Toxicity Tests ◽  
Treatment Efficiency ◽  
Landfill Leachates ◽  
Acute Toxicity Tests

ABSTRACT This work’s objective was to verify the leachates toxicity from pilot reactors (PR) simulating a landfill containing different concentrations of silver nanoparticles (AgNP). Acute toxicity tests (48 h) with Daphnia magna were carried out in leachates containing 50, 150 and 450 mg AgNP.kg-1, in addition to a blank for control. Toxicity tests with the pure solution of silver nanoparticle and leachates resulted by the reactors were performed. The acute toxicity tests performed with D. magna confirmed the toxicity of the leachates, as well as confirmed that the silver nanoparticles are toxic, presenting EC50 (48 h) of 0.63 µg.L-1 of pure nanoparticle and ranging from 1.52 to 3.37% for the leachates. Overall, the results from the present study indicate that exposures of aquatic invertebrates to silver nanoparticles could have important ecological effects on lower trophic levels in aquatic ecosystems. The results may contribute to a better understanding of the quality of municipal solid waste (MSW) landfill leachates, with reference to nanoparticle interference and consequent treatment efficiency.

Accumulation Dynamics and Acute Toxicity of Silver Nanoparticles toDaphnia magnaandLumbriculus variegatus: Implications for Metal Modeling Approaches

2015 ◽  
Vol 49 (7) ◽  
pp. 4389-4397 ◽  
Author(s):  
Farhan R. Khan ◽  
Kai B. Paul ◽  
Agnieszka D. Dybowska ◽  
Eugenia Valsami-Jones ◽  
Jamie R. Lead ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Acute Toxicity ◽  
Modeling Approaches
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