scholarly journals Mycotoxins: cytotoxicity and biotransformation in animal cells

2016 ◽  
Vol 5 (2) ◽  
pp. 377-387 ◽  
Author(s):  
Jikai Wen ◽  
Peiqiang Mu ◽  
Yiqun Deng
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Phase I ◽  
Cell Cycle Arrest ◽  
Phase Ii ◽  
Animal Cells ◽  
Phase Ii Enzymes ◽  
Cycle Arrest

Mycotoxins can be biotransformed by phase I and phase II enzymes in animals. However, most of the mycotoxin at high dosage combined with their metabolites can cause carcinogenesis and various cytotoxicity, such as apoptosis, lipids oxidation and cell cycle arrest,etc., and most of which are related to oxidative stress.

scholarly journals Estrogen-induced disruption of intracellular iron metabolism leads to oxidative stress, membrane damage, and cell cycle arrest in MCF-7 cells

Tumor Biology ◽  
2017 ◽  
Vol 39 (10) ◽  
pp. 101042831772618 ◽  
Author(s):  
Khuloud Bajbouj ◽  
Jasmin Shafarin ◽  
Maher Y Abdalla ◽  
Iman M Ahmad ◽  
Mawieh Hamad
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Iron Metabolism ◽  
Membrane Damage ◽  
Intracellular Iron ◽  
Cycle Arrest ◽  
Mcf 7

Evaluation of deoxynivalenol-induced toxic effects on DF-1 cells in vitro: Cell-cycle arrest, oxidative stress, and apoptosis

2014 ◽  
Vol 37 (1) ◽  
pp. 141-149 ◽  
Author(s):  
Daotong Li ◽  
Yaqiong Ye ◽  
Shaoqing Lin ◽  
Li Deng ◽  
Xiaolong Fan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Toxic Effects ◽  
Cycle Arrest

scholarly journals Copper-Binding Small Molecule Induces Oxidative Stress and Cell-Cycle Arrest in Glioblastoma-Patient-Derived Cells

2018 ◽  
Vol 25 (5) ◽  
pp. 585-594.e7 ◽  
Author(s):  
Kenichi Shimada ◽  
Eduard Reznik ◽  
Michael E. Stokes ◽  
Lakshmi Krishnamoorthy ◽  
Pieter H. Bos ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Small Molecule ◽  
Copper Binding ◽  
Glioblastoma Patient ◽  
Cycle Arrest

1,8-Cineole promotes G0/G1 cell cycle arrest and oxidative stress-induced senescence in HepG2 cells and sensitizes cells to anti-senescence drugs

Life Sciences ◽  
2020 ◽  
Vol 243 ◽  
pp. 117271 ◽  
Author(s):  
Boris Rodenak-Kladniew ◽  
Agustina Castro ◽  
Peter Stärkel ◽  
Marianela Galle ◽  
Rosana Crespo
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Hepg2 Cells ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest ◽  
And Oxidative Stress

scholarly journals MiR-210-3p protects endometriotic cells from oxidative stress-induced cell cycle arrest by targeting BARD1

2019 ◽  
Vol 10 (2) ◽  
Author(s):  
Yongdong Dai ◽  
Xiang Lin ◽  
Wenzhi Xu ◽  
Xiaona Lin ◽  
Qianmeng Huang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cycle Arrest

Oxidative stress induced by piperine leads to apoptosis in Candida albicans

2020 ◽  
Author(s):  
Archana Thakre ◽  
Vyankatesh Jadhav ◽  
Rubina Kazi ◽  
Amruta Shelar ◽  
Rajendra Patil ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Candida Albicans ◽  
Cell Cycle Arrest ◽  
Resistant Strain ◽  
Membrane Integrity ◽  
Synergistic Activity ◽  
Biofilm Growth ◽  
Cycle Arrest ◽  
Apoptosis Assay

Abstract Candida albicans is a member of pathogens with potential drug resistance threat that needs novel chemotherapeutic strategies. Considering the multifarious biological activities including bioenhancer activity, anti-Candida potential of piperine was evaluated against planktonic/biofilm and hyphal growth of C. albicans alone or in combination as a synergistic agent with fluconazole. Piperine inhibits planktonic growth at or less than 15 μg/ml, hyphae induction at 5 μg/ml concentration, and exhibits stage-dependent activity against biofilm growth of a fluconazole-resistant strain of C. albicans (ATCC10231). Though piperine couldn't kill inoculum completely at minimum inhibitory concentration (MIC), it is fungicidal at higher concentrations, as shown in apoptosis assay. FIC index values indicate that piperine exhibits excellent synergistic activity with fluconazole against planktonic (0.123) and biofilm (0.215) growth of an FLC resistant strain. Mode of anti-Candida activity was studied by identifying piperine responsive proteins wherein the abundance of 25 proteins involved in stress response, signal transduction and cell cycle were modulated (22 up and 3 down-regulated) significantly in response to piperine (MIC50). Modulation of the proteins involved suggests that piperine affects membrane integrity leading to oxidative stress followed by cell cycle arrest and apoptosis in C. albicans. Flow cytometry-based mitochondrial membrane potential (MMP), cell cycle and apoptosis assay, as well as real-time quantitative polymerase chain reaction analysis of selected genes, confirms piperine induced oxidative stress (TRR1), cell cycle arrest and apoptosis (CaMCA1). Based on our results, we conclude that piperine inhibits planktonic and difficult-to treat-biofilm growth of C. albicans by affecting membrane integrity thereby inducing oxidative stress and apoptosis. Lay Abstract Piperine inhibit Candida albicans growth (planktonic and biofilm) significantly in our study. Piperine exhibits excellent synergistic potential with fluconazole The proteome analysis suggests that piperine induced membrane damage leads to oxidative stress followed by cell cycle arrest and apoptosis.

Oxidative stress, cell cycle arrest and differentiation contribute toward the antiproliferative action of BSO and calcitriol on Caco-2 cells

2014 ◽  
Vol 25 (7) ◽  
pp. 810-818 ◽  
Author(s):  
Ana C. Liaudat ◽  
Luciana P. Bohl ◽  
Nori G. Tolosa de Talamoni ◽  
Belkys Maletto ◽  
María C. Pistoresi-Palencia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cycle Arrest ◽  
Antiproliferative Action
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