scholarly journals Grape seed proanthocyanidin extract protects against perfluorooctanoic acid-induced hepatotoxicity by attenuating inflammatory response, oxidative stress and apoptosis in mice

2016 ◽  
Vol 5 (1) ◽  
pp. 224-234 ◽  
Author(s):  
Wenwen Liu ◽  
Changshui Xu ◽  
Xi Sun ◽  
Haibin Kuang ◽  
Xiaodong Kuang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Response ◽  
Biological Activities ◽  
Health Benefits ◽  
Grape Seed ◽  
Perfluorooctanoic Acid ◽  
Rich Source ◽  
Potential Health ◽  
Grape Seed Proanthocyanidin Extract ◽  
Grape Seed Proanthocyanidin

Grape seed proanthocyanidin extract (GSPE) is a rich source of proanthocyanidins with multiple biological activities and potential health benefits.

scholarly journals Grape Seed Proanthocyanidin Extract Prevents Ovarian Aging by Inhibiting Oxidative Stress in the Hens

2018 ◽  
Vol 2018 ◽  
pp. 1-16 ◽  
Author(s):  
Xingting Liu ◽  
Xin Lin ◽  
Yuling Mi ◽  
Jian Li ◽  
Caiqiao Zhang
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Capacity ◽  
Chromatin Condensation ◽  
Natural Aging ◽  
Grape Seed ◽  
Protective Effects ◽  
Ovarian Aging ◽  
Grape Seed Proanthocyanidin Extract ◽  
Age Related ◽  
Grape Seed Proanthocyanidin

Oxidative stress is an important inducement in ovarian aging which results in fecundity decline in human and diverse animals. As a potent antioxidant, grape seed proanthocyanidin extract (GSPE) was investigated to ameliorate chicken ovarian aging in this study. Firstly, ovarian antioxidant capacity of hens at different ages (90, 150, 280, and 580 days old) was compared to elucidate its age-related changes. Subsequently, a D-gal-induced (2.5 mg/mL) aging ovarian model was established and the cultured ovarian tissues were treated with GSPE at 5 μg/mL for 72 h to evaluate the putative attenuating effects of GSPE on ovarian aging. Meanwhile, ovaries of D280 (young) and D580 (old) were treated with GSPE for 72 h in culture to verify the protective effects of GSPE on natural aging ovary. The results showed that GSPE could rescue the antioxidant capacity decline by increasing the antioxidase activities and their gene expression in either D-gal-induced or natural aging ovaries. Moreover, GSPE could maintain the homeostasis between cell proliferation and apoptosis in the D-gal-induced and natural aging ovaries, as well as alleviate D-gal-induced nucleus chromatin condensation in the ovarian granulosa cells. In conclusion, GSPE treatment can effectively prevent the ovarian aging process in hens by reducing oxidative stress.

Protection of Primary Glial Cells by Grape Seed Proanthocyanidin Extract against Nitrosative/ Oxidative Stress

Nitric Oxide ◽  
2001 ◽  
Vol 5 (2) ◽  
pp. 137-149 ◽  
Author(s):  
Sanjoy Roychowdhury ◽  
Gerald Wolf ◽  
Gerburg Keilhoff ◽  
Debasis Bagchi ◽  
Thomas Horn
Keyword(s):  
Oxidative Stress ◽  
Glial Cells ◽  
Grape Seed ◽  
Grape Seed Proanthocyanidin Extract ◽  
Grape Seed Proanthocyanidin

Ingestion of IH636 grape seed proanthocyanidin extract to prevent selenite-induced oxidative stress in experimental cataract

2006 ◽  
Vol 32 (6) ◽  
pp. 1041-1045 ◽  
Author(s):  
Ali H. Durukan ◽  
Cem Evereklioglu ◽  
Volkan Hurmeric ◽  
Hurkan Kerimoglu ◽  
Cuneyt Erdurman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Grape Seed ◽  
Grape Seed Proanthocyanidin Extract ◽  
Grape Seed Proanthocyanidin ◽  
Experimental Cataract

Grape seed proanthocyanidin extract prevents DDP-induced testicular toxicity in rats

2014 ◽  
Vol 5 (3) ◽  
pp. 605-611 ◽  
Author(s):  
Yan-meng Zhao ◽  
Li-ping Gao ◽  
Hai-lian Zhang ◽  
Jun-xia Guo ◽  
Pei-pei Guo
Keyword(s):  
Oxidative Stress ◽  
Grape Seed ◽  
Testicular Toxicity ◽  
Grape Seed Proanthocyanidin Extract ◽  
Grape Seed Proanthocyanidin

Oxidative stress has been proven to be involved in cisplatin (DDP)-induced toxicity.

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