Fluorene–morpholine-based organic nanoparticles: lysosome-targeted pH-triggered two-photon photodynamic therapy with fluorescence switch on–off

2016 ◽  
Vol 4 (10) ◽  
pp. 1862-1868 ◽  
Author(s):  
Moumita Gangopadhyay ◽  
Sourav K. Mukhopadhyay ◽  
Sree Gayathri ◽  
Sandipan Biswas ◽  
Shrabani Barman ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Real Time ◽  
Real Time Monitoring ◽  
Organic Nanoparticles ◽  
The Real ◽  
Two Photon ◽  
Fluorescence Switch

We synthesized fluorene–morpholine NPs that showed reversible fluorescence switch ON–OFF properties, which rendered the real time monitoring of PDT activity.

scholarly journals Real-Time Monitoring of Photocytotoxicity in Nanoparticles-Based Photodynamic Therapy: A Model-Based Approach

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e48617 ◽  
Author(s):  
Hamanou Benachour ◽  
Thierry Bastogne ◽  
Magali Toussaint ◽  
Yosra Chemli ◽  
Aymeric Sève ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Real Time ◽  
Real Time Monitoring ◽  
Model Based

A water-soluble benzoxazole-based probe: Real-time monitoring PPi via situ reaction by two-photon cells imaging

Talanta ◽  
2019 ◽  
Vol 195 ◽  
pp. 158-164 ◽  
Author(s):  
Dan Liu ◽  
Sheng Liu ◽  
Xinyu Zhang ◽  
Qiong Zhang ◽  
Jianhua Yu ◽  
...  
Keyword(s):  
Real Time ◽  
Water Soluble ◽  
Real Time Monitoring ◽  
Two Photon

Observing the real time formation of phosphine-ligated gold clusters by electrospray ionization mass spectrometry

2017 ◽  
Vol 19 (26) ◽  
pp. 17187-17198 ◽  
Author(s):  
Marshall R. Ligare ◽  
Grant E. Johnson ◽  
Julia Laskin
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
Real Time ◽  
Electrospray Ionization Mass Spectrometry ◽  
Gold Cluster ◽  
Gold Clusters ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Real Time Monitoring ◽  
The Real

Real-time monitoring of the gold cluster synthesis by electrospray ionization mass spectrometry reveals distinct formation pathways for Au8, Au9 and Au10 clusters.

scholarly journals NIR-Responsive Lysosomotropic Phototrigger: ʽAIE + ESIPTʼ Active Naphthalene Based Single Component Photoresponsive Nanocarrier with Two-Photon Uncaging and Real-Time Monitoring Ability

2021 ◽  
Author(s):  
Biswajit Roy ◽  
Rakesh Mengji ◽  
Samrat Roy ◽  
Bipul Pal ◽  
Avijit Jana ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Real Time ◽  
Near Infrared ◽  
Single Component ◽  
Photon Absorption ◽  
Real Time Monitoring ◽  
Two Photon ◽  
Nir Light

In recent times, organelle-targeted drug delivery systems gained tremendous attention due to the site specific delivery of active drug molecules resulting in enhanced bioefficacy. In this context, the phototriggered drug delivery system (DDS) for releasing an active molecule is superior as it provides spatial and temporal control over the release. So far, near infrared (NIR) light responsive organelle targeted DDS has not yet been developed. Hence, we introduced a two-photon NIR-light responsive lysosome targeted ʽAIE + ESIPTʼ active single component DDS based on naphthalene chromophore. The Two-photon absorption cross-section of our DDS is 142 GM at 850 nm. The DDS was converted into pure organic nanoparticles for biological applications. Our nano-DDS is capable of selective targeting, AIE-luminogenic imaging, and drug release within the lysosome. In vitro studies using cancerous cell lines showed that our single component photoresponsive nanocarrier exhibited enhanced cytotoxicity and real-time monitoring ability of the drug release.

A Unique Self-Reporting Photosensitizer Enabling Simultaneous Photodynamic Therapy and Real-Time Monitoring Phototheranostic Process in a Dynamic Dual-Color Mode

2021 ◽  
Author(s):  
Dong-Hui Wang ◽  
Li-Jian Chen ◽  
Xu Zhao ◽  
Xiu-Ping Yan
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Real Time ◽  
Small Molecule ◽  
Therapeutic Efficacy ◽  
Real Time Monitoring ◽  
Dual Color

Phototheranostics has attracted great interest in cancer therapy. Small-molecule self-reporting photosensitizers, one kind of idea agents in phototheranostics, enable simultaneous photodynamic therapy (PDT) and feedback of therapeutic efficacy. However, previous...

A Novel Hash Chain-Based Data Availability Monitoring Method for Off-site Disaster Recovery Architecture

2021 ◽  
pp. 2150294
Author(s):  
Neng Huang ◽  
Junxing Zhu ◽  
Chaonian Guo ◽  
Shuhan Cheng ◽  
Xiaoyong Li
Keyword(s):  
Information Systems ◽  
Real Time ◽  
Data Center ◽  
Disaster Recovery ◽  
Distributed Storage ◽  
Data Availability ◽  
Data Consistency ◽  
Real Time Monitoring ◽  
The Real ◽  
Hash Chain

With the rapid development of mobile Internet, there is a higher demand for the real-time, reliability and availability of information systems and to prevent the possible systemic risks of information systems, various business consistency standards and regulatory guidelines have been published, such as Recovery Time Object (RTO) and Recovery Point Object (RPO). Some of the current related researches focus on the standards, methods, management tools and technical frameworks of business consistency, while others study the data consistency algorithms in the cases of large data, cloud computing and distributed storage. However, few researchers have studied on how to monitor the data consistency and RPO of production-disaster recovery, and what architecture and technology should be applied in the monitoring. Moreover, in some information systems, due to the complex structures and distributions of data, it is difficult for traditional methods to quickly detect and accurately locate the first error data. Besides, due to the separation of production data center (PDC) and disaster recovery data center (DRDC), it is difficult to calculate the data difference and RPO between the two centers. This paper first discusses the architecture of remote distributed DRDCs. The architecture can make the disaster recovery (DR) system always online and the data always readable, and support the real-time monitoring of data availability, consistency as well as other related indicators, in this way to make DRDC out-of-the-box in disasters. Second, inspired by blockchain, this paper proposes a method to realize real-time monitoring of data consistency and RTO by building hash chains for PDC and DRDC. Third, this paper evaluates the hash chain operations from the algorithm time complexity, the data consistency, and the validity of RPO monitoring algorithms and since DR system is actually a kind of distributed system, the proposed approach can also be applied to the data consistency detection and data difference monitoring in other distributed systems.

An automated apparatus for the real-time monitoring of bioluminescence in plants

2005 ◽  
Vol 340 (2) ◽  
pp. 187-192 ◽  
Author(s):  
Kazuhisa Okamoto ◽  
Kiyoshi Onai ◽  
Norihiko Ezaki ◽  
Toru Ofuchi ◽  
Masahiro Ishiura
Keyword(s):  
Real Time ◽  
Real Time Monitoring ◽  
The Real
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