“Stealthy” chitosan/mesoporous silica nanoparticle based complex system for tumor-triggered intracellular drug release

2016 ◽  
Vol 4 (19) ◽  
pp. 3387-3397 ◽  
Author(s):  
Min Zhang ◽  
Jia Liu ◽  
Ying Kuang ◽  
Qilin Li ◽  
Hongyu Chen ◽  
...  
Keyword(s):  
Complex System ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticle ◽  
Mesoporous Silica Nanoparticle

A pH- and redox-sensitive “stealthy” chitosan/mesoporous silica nanoparticle-based complex system is prepared for tumor-triggered intracellular drug release.

Cucurbit[8]uril-mediated supramolecular photoswitching for self-preservation of mesoporous silica nanoparticle delivery system

2015 ◽  
Vol 51 (65) ◽  
pp. 12970-12973 ◽  
Author(s):  
Ning Ma ◽  
Wen-Jing Wang ◽  
Si Chen ◽  
Xiao-Shuang Wang ◽  
Xiao-Qiang Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Delivery System ◽  
Silica Nanoparticle ◽  
The Self ◽  
Mesoporous Silica Nanoparticle ◽  
Nanoparticle Delivery ◽  
Nanoparticle Surface ◽  
System P

The self peptide was introduced into the drug loaded mesoporous silica nanoparticle surface through a supramolecular photoswitchable heteroternary complexation, leading to photosensitive drug release.

scholarly journals Mesoporous silica nanoparticle-based intelligent drug delivery system for bienzyme-responsive tumour targeting and controlled release

2018 ◽  
Vol 5 (1) ◽  
pp. 170986 ◽  
Author(s):  
Yang Zhang ◽  
Juan Xu
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Controlled Release ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Cancer Cell ◽  
Silica Nanoparticle ◽  
Cell Targeting ◽  
Mesoporous Silica Nanoparticle ◽  
Cancer Cell Targeting

This paper proposes a novel type of multifunctional envelope-type mesoporous silica nanoparticle (MSN) to achieve cancer cell targeting and drug-controlled release. In this system, MSNs were first modified by active targeting moiety hyaluronic acid (HA) for breast cancer cell targeting and hyaluronidases (Hyal)-induced intracellular drug release. Then gelatin, a proteinaceous biopolymer, was grafted onto the MSNs to form a capping layer via glutaraldehyde-mediated cross-linking. To shield against unspecific uptake of cells and prolong circulation time, the nanoparticles were further decorated with poly(ethylene glycol) polymers (PEG) to obtain MSN@HA-gelatin-PEG (MHGP). Doxorubicin (DOX), as a model drug, was loaded into PEMSN to assess the breast cancer cell targeting and drug release behaviours. In vitro study revealed that PEG chains protect the targeting ligand and shield against normal cells. After reaching the breast cancer cells, MMP-2 overpressed by cells hydrolyses gelatin layer to deshield PEG and switch on the function of HA. As a result, DOX-loaded MHGP was selectively trapped by cancer cells through HA receptor-mediated endocytosis and subsequently release DOX due to Hyal-catalysed degradation of HA. This system presents successful bienzyme-responsive targeting drug delivery in an optimal fashion and provides potential applications for targeted cancer therapy.

scholarly journals Delivery of Ricin Toxin A-Chain by Peptide-Targeted Mesoporous Silica Nanoparticle-Supported Lipid Bilayers

2012 ◽  
Vol 1 (3) ◽  
pp. 348-353 ◽  
Author(s):  
Katharine Epler ◽  
David Padilla ◽  
Genevieve Phillips ◽  
Peter Crowder ◽  
Robert Castillo ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Lipid Bilayers ◽  
Silica Nanoparticle ◽  
Supported Lipid Bilayers ◽  
Toxin A ◽  
Mesoporous Silica Nanoparticle ◽  
Ricin Toxin ◽  
A Chain
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