scholarly journals Microfluidically fabricated pH-responsive anionic amphiphilic microgels for drug release

2016 ◽  
Vol 4 (18) ◽  
pp. 3086-3093 ◽  
Author(s):  
B. Lu ◽  
M. D. Tarn ◽  
N. Pamme ◽  
T. K. Georgiou
Keyword(s):  
Drug Release ◽  
Polymer Chains ◽  
Ph Responsive ◽  
Chip Design ◽  
Hydrophilic Monomer ◽  
On Chip

Novel amphiphilic microgels with hydrophobic and hydrophilic monomer units on the polymer chains were fabricated with an on-chip polymerisation methodology using a novel chip design.

Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

2018 ◽  
Vol 25 (25) ◽  
pp. 3036-3057 ◽  
Author(s):  
Xiao Sun ◽  
Guilong Zhang ◽  
Zhengyan Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Contrast Enhancement ◽  
General Strategy ◽  
Ph Responsive ◽  
Physicochemical Changes ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

Building a multi-FPGA-based emulation framework to support networks-on-chip design and verification

2010 ◽  
Vol 97 (10) ◽  
pp. 1241-1262 ◽  
Author(s):  
Yangfan Liu ◽  
Peng Liu ◽  
Yingtao Jiang ◽  
Mei Yang ◽  
Kejun Wu ◽  
...  
Keyword(s):  
Support Networks ◽  
Chip Design ◽  
Networks On Chip ◽  
On Chip

Mitochondrial alkaline pH-responsive drug release mediated by Celastrol loaded glycolipid-like micelles for cancer therapy

Biomaterials ◽  
2018 ◽  
Vol 154 ◽  
pp. 169-181 ◽  
Author(s):  
Yanan Tan ◽  
Yun Zhu ◽  
Yue Zhao ◽  
Lijuan Wen ◽  
Tingting Meng ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Alkaline Ph ◽  
Ph Responsive

Preparation of pH ‐responsive cellulose nanofibril/sodium alginate based hydrogels for drug release

2021 ◽  
pp. 51647
Author(s):  
Yuhang Li ◽  
Cong Wang ◽  
Yunhao Luan ◽  
Wanyi Liu ◽  
Tiantian Chen ◽  
...  
Keyword(s):  
Drug Release ◽  
Sodium Alginate ◽  
Cellulose Nanofibril ◽  
Ph Responsive

Integration of Al-Fill Processes for Contacts and VIAS

1996 ◽  
Vol 427 ◽  
Author(s):  
H. J. Barth
Keyword(s):  
High Pressure ◽  
Chip Design ◽  
Size And Shape ◽  
Future Developments ◽  
Pattern Density ◽  
New Challenges ◽  
On Chip ◽  
Damascene Interconnects ◽  
Low K ◽  
Electrical Data

AbstractToday different Al-fill techniques are used for the fill of submicron contacts and vias. The integration aspects of the most promising approaches, Al-reflow, cold/hot Al-planarization and high pressure Al-fill (Forcefill) are compared to the widely used W-plug technique. The filling properties are discussed with respect to future applications in ULSI devices. Special attention is given to the barrier stability in contacts and the influence on patterning. Various electrical data and reliability results are compared to metallizations with W-plugs. The implications of the Al-fill processes on chip design, especially on the size and shape of holes, the pattern density, the possibility of producing stacked contacts/vias and the metal to contact/via overlap are considered also. In an outlook for future developments, e.g. the introduction of low k dielectrics, the inverse metallization architecture with (dual) damascene interconnects and the emerging Cu metallizations, Alfill processes are facing new challenges which will be discussed.

Dual pH-responsive micelles with both charge-conversional property and hydrophobic–hydrophilic transition for effective cellular uptake and intracellular drug release

2016 ◽  
Vol 7 (12) ◽  
pp. 2202-2208 ◽  
Author(s):  
Shuai Li ◽  
Zhouxiang Zhao ◽  
Wei Wu ◽  
Chunmei Ding ◽  
Jianshu Li
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cellular Uptake ◽  
Diblock Copolymers ◽  
Effective Drug ◽  
Ph Responsive ◽  
A Charge

Two types of diblock copolymers are synthesized to construct dual pH-responsive micelles with a charge-conversional property for effective drug delivery.

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