Hollow ZrO2/PPy nanoplatform for improved drug delivery and real-time CT monitoring in synergistic photothermal-chemo cancer therapy

2016 ◽  
Vol 4 (5) ◽  
pp. 859-866 ◽  
Author(s):  
Longfei Tan ◽  
Tianlong Liu ◽  
Changhui Fu ◽  
Shengping Wang ◽  
Shiyan Fu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Real Time ◽  
Ct Imaging

Hollow ZrO2 nanospheres are fabricated to integrate polypyrrole and doxorubicin into one platform for synergistic photothermal-chemo therapy, and in vivo biodistribution is monitored by real-time CT imaging.

scholarly journals Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

2018 ◽  
Vol 115 (3) ◽  
pp. 501-506 ◽  
Author(s):  
Meng Qiu ◽  
Dou Wang ◽  
Weiyuan Liang ◽  
Liping Liu ◽  
Yin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Near Infrared ◽  
Black Phosphorus ◽  
Deep Penetration ◽  
Nir Light

A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.

Basil (Ocimum basilicum L.) seeds engender a smart material for intelligent drug delivery: On-Off switching and real-time swelling, in vivo transit detection, and mechanistic studies

2020 ◽  
Vol 155 ◽  
pp. 112780
Author(s):  
Bilal Ahmad Lodhi ◽  
Muhammad Ajaz Hussain ◽  
Muhammad Umer Ashraf ◽  
Muhammad Tahir Haseeb ◽  
Gulzar Muhammad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Real Time ◽  
Ocimum Basilicum ◽  
Smart Material ◽  
Mechanistic Studies

Functionalized Nanoscale Micelles Improve Drug Delivery for Cancer Therapy in Vitro and in Vivo

Nano Letters ◽  
2013 ◽  
Vol 13 (6) ◽  
pp. 2528-2534 ◽  
Author(s):  
Tuo Wei ◽  
Juan Liu ◽  
Huili Ma ◽  
Qiang Cheng ◽  
Yuanyu Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Improve Drug Delivery

Uniform hollow mesoporous silica nanocages for drug delivery in vitro and in vivo for liver cancer therapy

2011 ◽  
Vol 21 (14) ◽  
pp. 5299 ◽  
Author(s):  
Tingting Wang ◽  
Fang Chai ◽  
Qin Fu ◽  
Lingyu Zhang ◽  
Haiyan Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Liver Cancer ◽  
Mesoporous Silica ◽  
Hollow Mesoporous Silica

Near-infrared ratiometric self-assembled theranostic nanoprobe: imaging and tracking cancer chemotherapy

2020 ◽  
Vol 56 (25) ◽  
pp. 3629-3632 ◽  
Author(s):  
Xinwei Tian ◽  
Zhao Li ◽  
Ning Ding ◽  
Jiahang Zhang
Keyword(s):  
Cancer Therapy ◽  
Real Time ◽  
Cancer Chemotherapy ◽  
Near Infrared ◽  
Self Assembled

A novel near-infrared ratiometric fluorescent theranostic nanoprobe is applied for real-time fluorescence tracking and imaging cancer therapy in vivo and in situ.

Characterization and Anticancer Activities of Green Synthesized CuO Nanoparticles, A Review

2020 ◽  
Vol 20 ◽  
Author(s):  
Seyedeh R. Alizadeh ◽  
Mohammad A. Ebrahimzadeh
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Copper Oxide ◽  
Medical Science ◽  
Copper Oxide Nanoparticles ◽  
Cuo Nanoparticles ◽  
Oxide Nanoparticles ◽  
Anticancer Activities

Background: Cancer is defined as an abnormal/uncontrolled cell growth that shows rapid cell division. This disease is annually recognized in more than ten million people. Nanomaterials can be used as new strategies for cancer therapy. Nanostructured devices have developed for drug delivery and controlled release and created novel anticancer chemotherapies. Nanomaterials were taken into consideration because of their new properties, containing a large specific surface area and high reactivity. Copper oxide nanoparticles (CuONPs) have potential applications in many fields like heterogeneous catalysis, antibacterial, anticancer, antioxidant, antifungal, antiviral, imaging agents, and drug delivery agents in biomedicine. CuONPs display different physical properties, such as hightemperature superconductivity, electron correlation effects, and spin dynamics. NPs can be synthesized using different methods like physical, chemical, and biological methods. Methods: Copper oxide nanoparticles (CuONPs) have been suggested for its broad usage in biomedical applications. In this review, we tried to exhibit the results of significant anticancer activity of green synthesized CuONPs and their characterization by different analytical techniques such as UV-Vis, FT-IR, XRD, EDAX, DLS, SEM, and TEM. Results: The green method for the synthesis of CuO nanoparticles as eco-friendly, cost-effective, and facile method is the more effective method. Synthesized CuONPs from this method have an appropriate size and shape. The Green synthesized CuONPs exhibited high potential against several breast cancer (AMJ-13, MCF-7, and HBL-100 cell lines), cervical cancer (HeLa), colon cancer (HCT-116), gastric cancer (human adenocarcinoma AGS cell line), lung cancer (A549), leukemia cancer, and other cancers with the main toxicity approach of increasing ROS production. Conclusion: The present review confirms the importance of green synthesized CuO nanoparticles in medical science especially cancer therapy that exhibited high activity against different cancer in both in vitro and in vivo. The main toxicity approach of CuONPs is increasing the production of reactive oxygen species (ROS). It needs to perform more studies about in vivo cancer therapy and following clinical trial testing in the future. We believe that green synthesized CuO nanoparticles can be used for the improvement of different diseases.

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