scholarly journals Biodistribution and fate of core-labeled 125I polymeric nanocarriers prepared by Flash NanoPrecipitation (FNP)

2016 ◽  
Vol 4 (14) ◽  
pp. 2428-2434 ◽  
Author(s):  
Christina Tang ◽  
Jasmine Edelstein ◽  
John L. Mikitsh ◽  
Edward Xiao ◽  
Aaron H. Hemphill ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Flash Nanoprecipitation ◽  
Polymeric Nanocarriers ◽  
Translational Imaging

Flash NanoPrecipitation provides a facile, scalable platform for producing stable, radiolabeled PEGylated nanocarriers for drug delivery and translational imaging applications.

Efficient preparation of size tunable PEGylated gold nanoparticles

2016 ◽  
Vol 4 (28) ◽  
pp. 4813-4817 ◽  
Author(s):  
Christina Tang ◽  
Chris L. Sosa ◽  
Robert F. Pagels ◽  
Rodney D. Priestley ◽  
Robert K. Prud'homme
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Flash Nanoprecipitation ◽  
One Step ◽  
Translational Imaging

Flash NanoPrecipitation enables rapid, scalable, one-step synthesis of size-tunable PEGylated gold nanoparticles for drug delivery and translational imaging applications.

scholarly journals Polymeric Nanocarriers: A Transformation in Doxorubicin Therapies

Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2135
Author(s):  
Kamila Butowska ◽  
Anna Woziwodzka ◽  
Agnieszka Borowik ◽  
Jacek Piosik
Keyword(s):  
Drug Delivery ◽  
Wide Spectrum ◽  
Stimuli Responsive ◽  
First Line ◽  
Medical Expenses ◽  
Polymeric Nanocarriers ◽  
Essential Properties ◽  
Life Threatening ◽  
History Of ◽  
Cancerous Cells

Doxorubicin, a member of the anthracycline family, is a common anticancer agent often used as a first line treatment for the wide spectrum of cancers. Doxorubicin-based chemotherapy, although effective, is associated with serious side effects, such as irreversible cardiotoxicity or nephrotoxicity. Those often life-threatening adverse risks, responsible for the elongation of the patients’ recuperation period and increasing medical expenses, have prompted the need for creating novel and safer drug delivery systems. Among many proposed concepts, polymeric nanocarriers are shown to be a promising approach, allowing for controlled and selective drug delivery, simultaneously enhancing its activity towards cancerous cells and reducing toxic effects on healthy tissues. This article is a chronological examination of the history of the work progress on polymeric nanostructures, designed as efficient doxorubicin nanocarriers, with the emphasis on the main achievements of 2010–2020. Numerous publications have been reviewed to provide an essential summation of the nanopolymer types and their essential properties, mechanisms towards efficient drug delivery, as well as active targeting stimuli-responsive strategies that are currently utilized in the doxorubicin transportation field.

Recent Advances in Targeted Drug Delivery Approaches using Lipidic and Polymeric Nanocarriers for the management of Alzheimer’s Disease

2021 ◽  
Vol 27 ◽  
Author(s):  
Dhara Lakdawala ◽  
Md Abdur Rashid ◽  
Farhan Jalees Ahmad
Keyword(s):  
Alzheimer’S Disease ◽  
Drug Delivery ◽  
Alzheimer's Disease ◽  
Blood Brain Barrier ◽  
Targeted Drug Delivery ◽  
Brain Barrier ◽  
Polymeric Nanocarriers ◽  
Blood Brain ◽  
Targeted Drug ◽  
The Brain

: Drug delivery to the brain has remained a significant challenge in treating neurodegenerative disorders such as Alzheimer's disease due to the presence of the blood-brain barrier, which primarily obstructs the access of drugs and biomolecules into the brain. Several methods to overcome the blood-brain barrier have been employed, such as chemical disruption, surgical intervention, focused ultrasound, intranasal delivery and using nanocarriers. Nanocarrier systems remain the method of choice and have shown promising results over the past decade to achieve better drug targeting. Polymeric nanocarriers and lipidic nanoparticles act as a carrier system providing better encapsulation of drugs, site-specific delivery, increased bioavailability and sustained release of drugs. The surface modifications and functionalization of these nanocarrier systems have greatly facilitated targeted drug delivery. The safety and efficacy of these nanocarrier systems have been ascertained by several in vitro and in vivo models. In the present review, we have elaborated on recent developments of nanoparticles as a drug delivery system for Alzheimer's disease, explicitly focusing on polymeric and lipidic nanoparticles.

Polymeric nanocarriers in targeted drug delivery systems: A review

2020 ◽  
Vol 31 (12) ◽  
pp. 2939-2954 ◽  
Author(s):  
Payam Abasian ◽  
Sonya Ghanavati ◽  
Saeed Rahebi ◽  
Saied Nouri Khorasani ◽  
Shahla Khalili
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Polymeric Nanocarriers ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems

scholarly journals pH-dependent, thermosensitive polymeric nanocarriers for drug delivery to solid tumors

Biomaterials ◽  
2013 ◽  
Vol 34 (18) ◽  
pp. 4501-4509 ◽  
Author(s):  
Ching-Yi Chen ◽  
Tae Hee Kim ◽  
Wen-Chung Wu ◽  
Chi-Ming Huang ◽  
Hua Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Solid Tumors ◽  
Polymeric Nanocarriers ◽  
Ph Dependent

Fate of polymeric nanocarriers for oral drug delivery

2011 ◽  
Vol 16 (3) ◽  
pp. 228-237 ◽  
Author(s):  
Laurence Plapied ◽  
Nicolas Duhem ◽  
Anne des Rieux ◽  
Véronique Préat
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
Polymeric Nanocarriers

scholarly journals Evaluating the Mucoprotective Effects of Glycyrrhizic Acid Loaded Polymeric Nanoparticles Against 5-Fluorouracil Induced Intestinal Mucositis in Murine Model via Suppression of Inflammatory Mediators and Oxidative Stress

2021 ◽  
Author(s):  
Mahira Zeeshan ◽  
Ayesha Atiq ◽  
Qurat Ul Ain ◽  
Jawad Ali ◽  
Salman Khan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Inflammatory Mediators ◽  
Glycyrrhizic Acid ◽  
Plga Nanoparticles ◽  
Therapeutic Effects ◽  
Therapeutic Action ◽  
Polymeric Nanocarriers ◽  
Intestinal Mucositis ◽  
Anti Inflammatory

Abstract Objectives: 5-Flourouracil (5-FU), a chemotherapeutic drug, is linked with severe deteriorating effects on intestine leading to mucositis. Further, Glycyrrhizic acid is a renown herbal medicine with combined mucoprotective, antioxidant and anti-inflammatory actions, however associated with pharmacokinetics limitations. Owing to its remarkable therapeutic action in inflammatory bowel disease inside the polymeric nanocarriers, we have tried to explore its activity against 5-FU led intestinal mucositis. Polymeric nanocarriers proved to be efficient drug delivery vehicles for long-term remedy against inflammatory diseases, however, yet not explored for 5-FU induced mucositis. Therefore, the study aimed to produce Glycyrrhizic acid loaded poly lactic-co-glycolic acid (GA-PLGA) nanoparticles to evaluate its protective and therapeutic effects on intestinal mucosa against 5-FU mediated mucositis. Methods: For the said purpose, GA-PLGA nanoparticles were prepared using modified double emulsion method, physicochemically characterized and tested for invitro drug release. Thereafter, mucositis was induced by 5-FU (50 mg/kg; IP) administration to the mice for the first three days (day 0, 1, 2) and orally treated with GA-PLGA nanoparticles till seventh day (day 0-6). Results: GA-PLGA nanoparticles significantly reduced mucositis severity as manifested through recovered body weight, diarrhea score, distress, and anorexia. Further, 5-FU induced intestinal histopathological damage, altered villi-crypt length, low goblet cell count, elevated pro-inflammatory mediators and suppressed antioxidant enzymes were reversed by GA-PLGA nanoparticles’ sustained release therapeutic action. Conclusion: Morphological, behavioral, histological, and biochemical results suggested that GA-PLGA nanoparticles found to be efficient, biocompatible, targeted, sustained release drug delivery nano-vehicle for enhanced mucoprotective, anti-inflammatory and antioxidant effects in ameliorating 5-FU intestine mucositis.

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