scholarly journals On-demand, magnetic hyperthermia-triggered drug delivery: optimisation for the GI tract

2016 ◽  
Vol 4 (9) ◽  
pp. 1704-1711 ◽  
Author(s):  
Laili Che Rose ◽  
Joseph C. Bear ◽  
Paul Southern ◽  
Paul D. McNaughter ◽  
R. Ben Piggott ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Iron Oxide ◽  
Gastrointestinal Tract ◽  
Composite Coating ◽  
Magnetic Hyperthermia ◽  
Iron Oxide Nanoparticle ◽  
Gi Tract ◽  
On Demand ◽  
Oxide Nanoparticle

An orally-administered vehicle for targeted on-demand delivery to the gastrointestinal tract is presented. Hyperthermia is induced from an external AC magnetic field to melt a super paramagnetic iron oxide nanoparticle wax composite coating and hence release the capsule content.

Synthesis of spinel iron oxide nanoparticle/organic hybrid for hyperthermia

2008 ◽  
Vol 23 (12) ◽  
pp. 3415-3424 ◽  
Author(s):  
Koichiro Hayashi ◽  
Toshifumi Shimizu ◽  
Hidefumi Asano ◽  
Wataru Sakamoto ◽  
Toshinobu Yogo
Keyword(s):  
Magnetic Field ◽  
Iron Oxide ◽  
Photoelectron Spectroscopy ◽  
Iron Oxide Nanoparticle ◽  
Organic Hybrid ◽  
Oxide Nanoparticle ◽  
Hydrolysis Conditions ◽  
Size Controlled ◽  
Controlled Hydrolysis

Size-controlled spinel iron oxide (SIO) nanoparticle/organic hybrid was synthesized in situ from iron (III) allylacetylacetonate (IAA) at around 80 °C. The formation of SIO particles chemically bound with organics was confirmed by infrared and x-ray photoelectron spectroscopy. The sizes of SIO nanoparticles in the hybrids were monodispersed and ranged from 7 to 23 nm under controlled hydrolysis conditions. The hybrid including SIO particles of 7.3 nm was superparamagnetic, whereas those dispersed with particles above 11 nm were ferrimagnetic. The specific absorption rate (SAR) value was dependent upon the magnetic properties of the hybrid at 100 Oe. The SAR was 15.2 W g−1 in a 230 kHz alternating magnetic field and 100 Oe when the crystallite size of SIO particle in the hybrid was 16 nm. The temperatures of agars dispersed with hybrid powders of 5 and 8 mg ml−1 reached the optimum temperature (42 °C) for 17 and 8 min, respectively. The increase in temperature was controlled in terms of the strength of magnetic field. The simulation of heat transfer in the agar phantom model revealed that the suitable temperature distribution for therapy was attained from 15 to 20 min at 230 kHz and 100 Oe.

scholarly journals Targeted Delivery of Iron Oxide Nanoparticle-Loaded Human Embryonic Stem Cell-Derived Spherical Neural Masses for Treating Intracerebral Hemorrhage

2020 ◽  
Vol 21 (10) ◽  
pp. 3658
Author(s):  
Min Kyoung Kang ◽  
Tae Jung Kim ◽  
Young-Ju Kim ◽  
Lamie Kang ◽  
Jonghoon Kim ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Stem Cells ◽  
Stem Cell ◽  
Iron Oxide ◽  
External Magnetic Field ◽  
Targeted Delivery ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticle

This study evaluated the potential of iron oxide nanoparticle-loaded human embryonic stem cell (ESC)-derived spherical neural masses (SNMs) to improve the transportation of stem cells to the brain, ameliorate brain damage from intracerebral hemorrhage (ICH), and recover the functional status after ICH under an external magnetic field of a magnet attached to a helmet. At 24 h after induction of ICH, rats were randomly separated into three experimental groups: ICH with injection of phosphate-buffered saline (PBS group), ICH with intravenous injection of magnetosome-like ferrimagnetic iron oxide nanocubes (FION)-labeled SNMs (SNMs* group), and ICH with intravenous injection of FION-labeled SNMs followed by three days of external magnetic field exposure for targeted delivery by a magnet-embedded helmet (SNMs*+Helmet group). On day 3 after ICH induction, an increased Prussian blue-stained area and decreased swelling volume were observed in the SNMs*+Helmet group compared with that of the other groups. A significantly decreased recruitment of macrophages and neutrophils and a downregulation of pro-inflammatory cytokines followed by improved neurological function three days after ICH were observed in the SNMs*+Helmet group. Hemispheric atrophy at six weeks after ICH was significantly decreased in the SNMs*+Helmet group compared with that of the PBS group. In conclusion, we have developed a targeted delivery system using FION tagged to stem cells and a magnet-embedded helmet. The targeted delivery of SNMs might have the potential for developing novel therapeutic strategies for ICH.

scholarly journals IGF-1 Conjugated Sub-5 nm Ultrafine Iron Oxide Nanoparticle Enhances Targeted Drug Delivery and Efficacy of DNA Topoisomerase Inhibitor SN38 for Pancreatic Cancer: An in Vitro Study

2022 ◽  
Author(s):  
Peijia Xu ◽  
Ting Xue ◽  
Jonathan Padelford ◽  
Xingkui Xue ◽  
Alyssa Y Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Iron Oxide ◽  
Drug Loading ◽  
Pancreatic Tumors ◽  
Iron Oxide Nanoparticle ◽  
Cell Targeting ◽  
Pancreatic Cancer Cells ◽  
Tumor Delivery ◽  
Oxide Nanoparticle

Abstract Background Pancreatic cancer remains one of the most lethal cancers largely due to the inefficient delivery of therapeutics. Nanomaterials have been extensively investigated as drug delivery platforms, showing improved drug pharmacodynamics and pharmacokinetics. However, their applications in pancreatic cancer have not yet been successful due to limited tumor delivery caused by dense tumor stroma and distorted tumor vasculatures. Meanwhile, smaller-sized nanomaterials have shown improved tumor delivery and retention in various tumors, including pancreatic tumors, suggesting their potential in enhancing drug delivery. Methods An ultrafine iron oxide nanoparticle (uIONP) was used to encapsulate 7-ethyl-10-hydroxyl camptothecin (SN38), the water-insoluble active metabolite of chemotherapy drug irinotecan for treating pancreatic cancer in clinic. Insulin-like growth factor 1 (IGF-1) was conjugated to uIONP as a ligand for targeting pancreatic cancer and stromal cells overexpressing IGF-1 receptor (IGF1R). The SN38 loading and release profile were characterized. The cancer cell targeting and induced apoptosis by developed nano-formulationIGF1-uIONP/SN38 were also investigated. Results IGF1-uIONP/SN38 demonstrated stable drug loading in physiological pH with the loading efficiency of 68.2 ± 3.5% (SN38/Fe, wt%) and <7% release for 24 hours. In tumor-interstitial- and lysosomal-mimicking pH (6.5 and 5.5), 52.2 and 91.3% of encapsulated SN38 were released over 24 hours. The IGF1-uIONP/SN38 exhibited specific receptor-mediated cell targeting and cytotoxicity to MiaPaCa-2 cells with IC50 of 11.8 ± 2.3 nM, but not to HEK293 human embryonic kidney cells. Conclusion The IGF1-uIONP significantly improved the delivery of SN38 to targeted pancreatic cancer cells, holding the potential for in vivo theranostic applications.

Iron oxide nanoparticle core-shell magnetic microspheres: Applications toward targeted drug delivery

2020 ◽  
Vol 24 ◽  
pp. 102134 ◽  
Author(s):  
Srinivasan Ayyanaar ◽  
Mookkandi Palsamy Kesavan ◽  
Chandrasekar Balachandran ◽  
Swetha Rasala ◽  
Perumal Rameshkumar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Targeted Drug Delivery ◽  
Magnetic Microspheres ◽  
Iron Oxide Nanoparticle ◽  
Core Shell ◽  
Oxide Nanoparticle ◽  
Targeted Drug ◽  
Nanoparticle Core

Effect of Iron Oxide Nanoparticle Shape on Doxorubicin Drug Delivery Toward LNCaP and PC-3 Cell Lines

2018 ◽  
Vol 8 (1) ◽  
pp. 394-406 ◽  
Author(s):  
T. R. Nizamov ◽  
A. S. Garanina ◽  
I. S. Grebennikov ◽  
O. A. Zhironkina ◽  
O. S. Strelkova ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Cell Lines ◽  
Iron Oxide Nanoparticle ◽  
Nanoparticle Shape ◽  
Oxide Nanoparticle
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