scholarly journals Enhanced user-control of small molecule drug release from a poly(ethylene glycol) hydrogel via azobenzene/cyclodextrin complex tethers

2016 ◽  
Vol 4 (6) ◽  
pp. 1035-1039 ◽  
Author(s):  
Eric M. Nehls ◽  
Adrianne M. Rosales ◽  
Kristi S. Anseth
Keyword(s):  
Drug Release ◽  
Ethylene Glycol ◽  
Small Molecule ◽  
Release Rate ◽  
Poly Ethylene Glycol ◽  
Small Peptide ◽  
Cyclodextrin Complex ◽  
Small Molecule Drug ◽  
Poly Ethylene ◽  
Host Chemistry

Photoresponsive azobenzene–cyclodextrin guest–host chemistry can be used to control the release rate of a small peptide from a PEG hydrogel with light.

scholarly journals Tailoring Atomoxetine Release Rate from DLP 3D-Printed Tablets Using Artificial Neural Networks: Influence of Tablet Thickness and Drug Loading

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 111
Author(s):  
Gordana Stanojević ◽  
Djordje Medarević ◽  
Ivana Adamov ◽  
Nikola Pešić ◽  
Jovana Kovačević ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Release Rate ◽  
Drug Loading ◽  
Prolonged Release ◽  
Cylindrical Shape ◽  
Poly Ethylene Glycol ◽  
Scanning Calorimetry ◽  
3D Printed ◽  
Artificial Neural ◽  
Poly Ethylene

Various three-dimensional printing (3DP) technologies have been investigated so far in relation to their potential to produce customizable medicines and medical devices. The aim of this study was to examine the possibility of tailoring drug release rates from immediate to prolonged release by varying the tablet thickness and the drug loading, as well as to develop artificial neural network (ANN) predictive models for atomoxetine (ATH) release rate from DLP 3D-printed tablets. Photoreactive mixtures were comprised of poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) 400 in a constant ratio of 3:1, water, photoinitiator and ATH as a model drug whose content was varied from 5% to 20% (w/w). Designed 3D models of cylindrical shape tablets were of constant diameter, but different thickness. A series of tablets with doses ranging from 2.06 mg to 37.48 mg, exhibiting immediate- and modified-release profiles were successfully fabricated, confirming the potential of this technology in manufacturing dosage forms on demand, with the possibility to adjust the dose and release behavior by varying drug loading and dimensions of tablets. DSC (differential scanning calorimetry), XRPD (X-ray powder diffraction) and microscopic analysis showed that ATH remained in a crystalline form in tablets, while FTIR spectroscopy confirmed that no interactions occurred between ATH and polymers.

Reversibly cross-linked poly(ethylene glycol)–poly(amino acid)s copolymer micelles: a promising approach to overcome the extracellular stability versus intracellular drug release challenge

RSC Advances ◽  
2015 ◽  
Vol 5 (26) ◽  
pp. 20025-20034 ◽  
Author(s):  
Yuling Li ◽  
Sai Wang ◽  
Dandan Zhu ◽  
Yuling Shen ◽  
Baixiang Du ◽  
...  
Keyword(s):  
Amino Acid ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Lipoic Acid ◽  
Triblock Copolymer ◽  
Intracellular Delivery ◽  
Poly Ethylene Glycol ◽  
Copolymer Micelles ◽  
Poly Ethylene ◽  
Copolymer Poly

Reversibly shell cross-linked micelles based on a lipoic acid (LA) decorated triblock copolymer poly(ethylene glycol)-b-poly(γ-benzyl-l-glutamate)-b-poly(l-phenylalanine) have been developed for efficient intracellular delivery of DOX.

Controlled Release Behaviors of Ketoprofen from Matrix Polymer of Chitosan and poly(ethylene glycol)

2013 ◽  
Vol 813 ◽  
pp. 399-402
Author(s):  
Chimsook Thitipha ◽  
Thitiphan Chimsook
Keyword(s):  
Particle Size ◽  
Controlled Release ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Diffusion Method ◽  
Poly Ethylene Glycol ◽  
Matrix Polymer ◽  
Percentage Yield ◽  
Poly Ethylene ◽  
Composition Ratios

The aim of present work was to prepare floating microsphere of ketoprofen using matrix polymer of chitosan and poly (ethylene glycol) by solvent diffusion method. The floating microsphere of ketoprofen was prepared from matrix polymer of chitosan and poly (ethylene glycol) with various composition ratios and evaluated such as particle size, drug compatibility and drug release of microspheres. The scanning electron microscopy of microspheres confirmed their hollow structures with smooth surface. Formulation CPK 4 to CPK 6 exhibited the best controlled release pattern in ketoprofen. The concentration and size of poly (ethylene-glycol) affected the particle size, percentage yield and drug release of microspheres.

scholarly journals Hydrolysis and drug release from poly(ethylene glycol)-modified lactone polymers with open porosity

2019 ◽  
Vol 113 ◽  
pp. 165-175 ◽  
Author(s):  
Sanja Asikainen ◽  
Kaarlo Paakinaho ◽  
Anna-Kaisa Kyhkynen ◽  
Markus Hannula ◽  
Minna Malin ◽  
...  
Keyword(s):  
Drug Release ◽  
Ethylene Glycol ◽  
Open Porosity ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Star-shaped poly(l-lactide)-b-poly(ethylene glycol) with porphyrin core: synthesis, self-assembly, drug-release behavior and singlet oxygen research

2014 ◽  
Vol 38 (8) ◽  
pp. 3569-3578 ◽  
Author(s):  
Xiao-Hui Dai ◽  
Zhi-Ming Wang ◽  
Lu-You Gao ◽  
Jian-Ming Pan ◽  
Xiao-Hong Wang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Block Copolymer ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Release Behavior ◽  
Poly Ethylene Glycol ◽  
Drug Release Behavior ◽  
Porphyrin Core ◽  
Poly Ethylene

pH-induced block copolymer SPPLA-b-PEG with porphyrin core for photodynamic therapy.

Conjugation of biphenyl groups with poly(ethylene glycol) to enhance inhibitory effects on the PD-1/PD-L1 immune checkpoint interaction

2020 ◽  
Vol 8 (44) ◽  
pp. 10162-10171
Author(s):  
Eun-Hye Kim ◽  
Boyang Ning ◽  
Masuki Kawamoto ◽  
Hideyuki Miyatake ◽  
Eiry Kobatake ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Small Molecule ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Inhibitory Effect ◽  
Inhibitory Effects ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Multivalent Effect

Inhibitory effect of small molecule immune checkpoint inhibitors on the PD-1/PD-L1 immune checkpoint interaction was enhanced by the multivalent effect through the conjugation of branched PEG.

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