Strategies for skeletal muscle tissue engineering: seed vs. soil

2015 ◽  
Vol 3 (40) ◽  
pp. 7881-7895 ◽  
Author(s):  
Brian M. Sicari ◽  
Ricardo Londono ◽  
Stephen F. Badylak
Keyword(s):  
Skeletal Muscle ◽  
Tissue Engineering ◽  
Ex Vivo ◽  
Three Dimensional ◽  
Scaffold Material ◽  
Cell Recruitment ◽  
Soil P ◽  
Tissue Replacement ◽  
Tissue Engineering Approach ◽  
Scaffold Materials

The most commonly used tissue engineering approach includes theex vivocombination of site-appropriate cell(s) and scaffold material(s) to create three-dimensional constructs for tissue replacement or reconstruction. Biologic scaffold materials facilitate endogenous cell recruitment.

scholarly journals Special Issue: Application of Extracellular Matrix in Regenerative Medicine

2021 ◽  
Vol 11 (7) ◽  
pp. 3262
Author(s):  
Neill J. Turner
Keyword(s):  
Extracellular Matrix ◽  
Regenerative Medicine ◽  
Wound Repair ◽  
Three Dimensional ◽  
Dynamic Structure ◽  
Scaffold Material ◽  
Special Issue ◽  
Organ Regeneration ◽  
Scaffold Materials ◽  
The Many

The present Special Issue comprises a collection of articles addressing the many ways in which extracellular matrix (ECM), or its components parts, can be used in regenerative medicine applications. ECM is a dynamic structure, composed of a three-dimensional architecture of fibrous proteins, proteoglycans, and glycosaminoglycans, synthesized by the resident cells. Consequently, ECM can be considered as nature’s ideal biologic scaffold material. The articles in this Special Issue cover a range of topics from the use of ECM components to manufacture scaffold materials, understanding how changes in ECM composition can lead to the development of disease, and how decellularization techniques can be used to develop tissue-derived ECM scaffolds for whole organ regeneration and wound repair. This editorial briefly summarizes the most interesting aspects of these articles.

Complexity Analysis in Additive Manufacturing for the Production of Tissue Engineering Constructs

2014 ◽  
pp. 240-257
Author(s):  
Kouroush Jenab ◽  
Philip D. Weinsier
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Human Tissue ◽  
Complexity Analysis ◽  
Three Dimensional ◽  
Solid Object ◽  
Tissue Replacement ◽  
3D Solid ◽  
Process Complexity ◽  
Am Processes

Additive Manufacturing (AM) is a process of making a Three-Dimensional (3D) solid object of virtually any shape from a digital model that is used for both prototyping and distributed manufacturing with applications in many fields, such as dental and medical industries and biotech (human tissue replacement). AM refers to technologies that create objects through a sequential layering process. AM processes have several primary areas of complexity that may not be measured precisely, due to uncertain situations. Therefore, this chapter reports an analytical model for evaluating process complexity that takes into account uncertain situations and additive manufacturing process technologies. The model is able to rank AM processes based on their relative complexities. An illustrative example for several processes is demonstrated in order to present the application of the model.

Complexity Analysis in Additive Manufacturing for the Production of Tissue Engineering Constructs

2020 ◽  
pp. 370-393
Author(s):  
Kouroush Jenab ◽  
Philip D. Weinsier
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Human Tissue ◽  
Complexity Analysis ◽  
Three Dimensional ◽  
Solid Object ◽  
Tissue Replacement ◽  
3D Solid ◽  
Process Complexity ◽  
Am Processes

Additive Manufacturing (AM) is a process of making a Three-Dimensional (3D) solid object of virtually any shape from a digital model that is used for both prototyping and distributed manufacturing with applications in many fields, such as dental and medical industries and biotech (human tissue replacement). AM refers to technologies that create objects through a sequential layering process. AM processes have several primary areas of complexity that may not be measured precisely, due to uncertain situations. Therefore, this chapter reports an analytical model for evaluating process complexity that takes into account uncertain situations and additive manufacturing process technologies. The model is able to rank AM processes based on their relative complexities. An illustrative example for several processes is demonstrated in order to present the application of the model.

Combined Effects of Scaffold Material and Mechanical Stimulation on the Formation of Tissue Engineered Constructs Using Tendon and Ligament Progenitor Cells

2013 ◽  
Author(s):  
Andrew P. Breidenbach ◽  
Nathaniel A. Dyment ◽  
Yinhui Lu ◽  
Jason T. Shearn ◽  
David W. Rowe ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Progenitor Cells ◽  
Three Dimensional ◽  
Musculoskeletal Injuries ◽  
Combined Effects ◽  
Joint Movement ◽  
Scaffold Material ◽  
Ligament Injuries ◽  
Promising Alternative

Tendon and ligament injuries account for one-third of all musculoskeletal injuries [1]. Collagen fibrils in these mechanosensitive tissues transmit forces to mobilize and stabilize joint movement. Donor tissues used to repair these tissues often lack the mechanical properties of the tissue they are replacing. One promising alternative using tissue engineering combines stem/progenitor cells in three-dimensional tissue engineered constructs (TECs).

scholarly journals Emergence of Three Dimensional Printed Cardiac Tissue: Opportunities and Challenges in Cardiovascular Diseases

2019 ◽  
Vol 15 (3) ◽  
pp. 188-204 ◽  
Author(s):  
Nitin B. Charbe ◽  
Flavia C. Zacconi ◽  
Nikhil Amnerkar ◽  
Dinesh Pardhi ◽  
Priyank Shukla ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cardiac Tissue ◽  
Ex Vivo ◽  
Interdisciplinary Collaboration ◽  
Three Dimensional ◽  
Heterogeneous Material ◽  
Lessons Learned ◽  
Full Potential ◽  
Therapeutic Outcomes

Three-dimensional (3D) printing, also known as additive manufacturing, was developed originally for engineering applications. Since its early advancements, there has been a relentless development in enthusiasm for this innovation in biomedical research. It allows for the fabrication of structures with both complex geometries and heterogeneous material properties. Tissue engineering using 3D bio-printers can overcome the limitations of traditional tissue engineering methods. It can match the complexity and cellular microenvironment of human organs and tissues, which drives much of the interest in this technique. However, most of the preliminary evaluations of 3Dprinted tissues and organ engineering, including cardiac tissue, relies extensively on the lessons learned from traditional tissue engineering. In many early examples, the final printed structures were found to be no better than tissues developed using traditional tissue engineering methods. This highlights the fact that 3D bio-printing of human tissue is still very much in its infancy and more work needs to be done to realise its full potential. This can be achieved through interdisciplinary collaboration between engineers, biomaterial scientists and molecular cell biologists. This review highlights current advancements and future prospects for 3D bio-printing in engineering ex vivo cardiac tissue and associated vasculature, such as coronary arteries. In this context, the role of biomaterials for hydrogel matrices and choice of cells are discussed. 3D bio-printing has the potential to advance current research significantly and support the development of novel therapeutics which can improve the therapeutic outcomes of patients suffering fatal cardiovascular pathologies.

Informatics Challenges in Tissue Engineering and Biomaterials

2003 ◽  
Vol 17 (1) ◽  
pp. 49-54 ◽  
Author(s):  
D. Rekow
Keyword(s):  
Tissue Engineering ◽  
Clinical Performance ◽  
Three Dimensional ◽  
Thin Layers ◽  
Material Surface ◽  
Dental Restorations ◽  
Scaffold Materials ◽  
Ceramic Crowns ◽  
Three Dimensional Configuration

Both tissue engineering and biomaterials have made tremendous strides recently, yet major questions remain unanswered. Tissue-engineered products have come to the market; others are in development. A fundamental issue that informatics could address for tissue engineering is to describe and to predict the cascade of biochemical and cellular reactions that occur as a function of time and implant material: surface texture, microporosity; pore size, density, and connectivity; and three-dimensional configuration. Behavior of ceramics, a subset of tissue-engineering scaffold materials and a mainstay of dental restorations, has been studied extensively for very thin layers and for thicknesses greater than 2 mm. Until recently, little has been known about dentally relevant thickness of 1–2 mm. Results have been surprising and are continuing to develop. Still, at least one fundamental question remains that could be addressed by informatics techniques: Where, along the spectrum of flat-polished material to 10-year clinical in vivo study, can we test to predict clinical performance of all-ceramic crowns accurately?

scholarly journals Research Progress on Tissue Engineering of Main Tissues and Organs of Human Body

2021 ◽  
Vol 245 ◽  
pp. 03043
Author(s):  
Zhirui Jin
Keyword(s):  
Tissue Engineering ◽  
Human Health ◽  
Industrial Development ◽  
Alternative Therapy ◽  
Three Dimensional ◽  
Fundamental Solutions ◽  
Research Progress ◽  
Engineering Technology ◽  
Potential Alternative ◽  
Scaffold Materials

The injury and failure diseases of human tissues and organs, such as heart failure and chronic kidney disease, seriously threaten human health and life safety. At present, however, organ transplantation has obvious limitations, and tissue engineering is considered as a potential alternative therapy. Tissue engineering uses the construction of cells, biomaterials and bioreactors to develop three-dimensional artificial tissues and organs for the enhancement, repair and replacement of damaged or diseased tissues and organs, which contributes to the fundamental solutions of diseases of tissues and organs as well as to the improvement of human health. This paper introduces the research progress of tissue engineering technology in the field of living organs from three aspects: seed cells, application of growth factors and biomimetic preparation of functionalized scaffold materials, hoping to provide help and ideas for the research and industrial development of the repair and reconstruction of human organs.

scholarly journals Information-Driven Design as a Potential Approach for 3D Printing of Skeletal Muscle Biomimetic Scaffolds

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1986
Author(s):  
Silvia Baiguera ◽  
Costantino Del Gaudio ◽  
Felicia Carotenuto ◽  
Paolo Di Nardo ◽  
Laura Teodori
Keyword(s):  
Skeletal Muscle ◽  
Tissue Engineering ◽  
Healing Process ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Muscle Injuries ◽  
Clinical Issue ◽  
Potential Approach ◽  
Biomimetic Scaffolds ◽  
Experimental Protocols

Severe muscle injuries are a real clinical issue that still needs to be successfully addressed. Tissue engineering can represent a potential approach for this aim, but effective healing solutions have not been developed yet. In this regard, novel experimental protocols tailored to a biomimetic approach can thus be defined by properly systematizing the findings acquired so far in the biomaterials and scaffold manufacturing fields. In order to plan a more comprehensive strategy, the extracellular matrix (ECM), with its properties stimulating neomyogenesis and vascularization, should be considered as a valuable biomaterial to be used to fabricate the tissue-specific three-dimensional structure of interest. The skeletal muscle decellularized ECM can be processed and printed, e.g., by means of stereolithography, to prepare bioactive and biomimetic 3D scaffolds, including both biochemical and topographical features specifically oriented to skeletal muscle regenerative applications. This paper aims to focus on the skeletal muscle tissue engineering sector, suggesting a possible approach to develop instructive scaffolds for a guided healing process.

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