Facile synthesis of yolk–shell silica nanoparticles for targeted tumor therapy

2015 ◽  
Vol 3 (42) ◽  
pp. 8303-8313 ◽  
Author(s):  
Liangliang Dai ◽  
Qingfeng Zhang ◽  
Hao Gu ◽  
Kaiyong Cai
Keyword(s):  
Silica Nanoparticles ◽  
High Efficiency ◽  
Tumor Therapy ◽  
Facile Synthesis ◽  
Redox Responsive

Redox-responsive yolk–shell silica nanoparticles end-capped with rotaxane nanovalves were fabricated for targeted tumor therapy with high efficiency.

Redox-Responsive Nanocarrier Based on Heparin End-Capped Mesoporous Silica Nanoparticles for Targeted Tumor Therapy in Vitro and in Vivo

Langmuir ◽  
2014 ◽  
Vol 30 (26) ◽  
pp. 7867-7877 ◽  
Author(s):  
Liangliang Dai ◽  
Jinghua Li ◽  
Beilu Zhang ◽  
Junjie Liu ◽  
Zhong Luo ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Tumor Therapy ◽  
Redox Responsive

A pH-responsive nanocontainer based on hydrazone-bearing hollow silica nanoparticles for targeted tumor therapy

2016 ◽  
Vol 4 (26) ◽  
pp. 4594-4604 ◽  
Author(s):  
Liangliang Dai ◽  
Qingfeng Zhang ◽  
Xinkun Shen ◽  
Qiang Sun ◽  
Caiyun Mu ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Silica Nanoparticles ◽  
High Efficiency ◽  
Tumor Therapy ◽  
Ph Responsive ◽  
Hollow Silica ◽  
Good Biocompatibility ◽  
Hollow Silica Nanoparticles

pH-responsive hollow silica nanoparticles blocked with hyaluronic acid molecules for targeted tumor therapy with high efficiency and good biocompatibility.

Metabolism and Distribution of Novel Tumor Targeting Drugs In Vivo

2020 ◽  
Vol 21 (13) ◽  
pp. 996-1008
Author(s):  
Mengli Wang ◽  
Qiuzheng Du ◽  
Lihua Zuo ◽  
Peng Xue ◽  
Chao Lan ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Small Molecule ◽  
High Efficiency ◽  
Tumor Therapy ◽  
Research Progress ◽  
Future Research ◽  
Pharmacokinetic Parameters ◽  
Molecular Characteristics ◽  
Targeted Drugs

Background: As a new tumor therapy, targeted therapy is becoming a hot topic due to its high efficiency and low toxicity. Drug effects of targeted tumor drugs are closely related to pharmacokinetics, so it is important to understand their distribution and metabolism in vivo. Methods: A systematic review of the literature on the metabolism and distribution of targeted drugs over the past 20 years was conducted, and the pharmacokinetic parameters of approved targeted drugs were summarized in combination with the FDA's drug instructions. Targeting drugs are divided into two categories: small molecule inhibitors and monoclonal antibodies. Novel targeting drugs and their mechanisms of action, which have been developed in recent years, are summarized. The distribution and metabolic processes of each drug in the human body are reviewed. Results: In this review, we found that the distribution and metabolism of small molecule kinase inhibitors (TKI) and monoclonal antibodies (mAb) showed different characteristics based on the differences of action mechanism and molecular characteristics. TKI absorbed rapidly (Tmax ≈ 1-4 h) and distributed in large amounts (Vd > 100 L). It was mainly oxidized and reduced by cytochrome P450 CYP3A4. However, due to the large molecular diameter, mAb was distributed to tissues slowly, and the volume of distribution was usually very low (Vd < 10 L). It was mainly hydrolyzed and metabolized into peptides and amino acids by protease hydrolysis. In addition, some of the latest drugs are still in clinical trials, and the in vivo process still needs further study. Conclusion: According to the summary of the research progress of the existing targeting drugs, it is found that they have high specificity, but there are still deficiencies in drug resistance and safety. Therefore, the development of safer and more effective targeted drugs is the future research direction. Meanwhile, this study also provides a theoretical basis for clinical accurate drug delivery.

Sodium Chloride Modified Silica Nanoparticles as a Non-Viral Vector with a High Efficiency of DNA Transfer into Cells

2003 ◽  
Vol 3 (3) ◽  
pp. 273-279 ◽  
Author(s):  
Yuxiang Chen ◽  
Zhigang Xue ◽  
Duo Zheng ◽  
Kun Xia ◽  
Yanzhong Zhao ◽  
...  
Keyword(s):  
Sodium Chloride ◽  
Silica Nanoparticles ◽  
High Efficiency ◽  
Viral Vector ◽  
Dna Transfer ◽  
Modified Silica ◽  
Modified Silica Nanoparticles

scholarly journals Correction: Facile synthesis of ultrathin Ni-MOF nanobelts for high-efficiency determination of glucose in human serum

2020 ◽  
Vol 8 (25) ◽  
pp. 5547-5548
Author(s):  
Xiao Xiao ◽  
Shasha Zheng ◽  
Xinran Li ◽  
Guangxun Zhang ◽  
Xiaotian Guo ◽  
...  
Keyword(s):  
Human Serum ◽  
High Efficiency ◽  
Facile Synthesis ◽  
Efficiency Determination

Correction for ‘Facile synthesis of ultrathin Ni-MOF nanobelts for high-efficiency determination of glucose in human serum’ by Xiao Xiao et al., J. Mater. Chem. B, 2017, 5, 5234–5239, DOI: 10.1039/C7TB00180K.

Facile Synthesis of Well-dispersed Hollow Mesoporous Silica Nanoparticles Using Iron Oxide Nanoparticles as Template

2013 ◽  
Vol 42 (3) ◽  
pp. 316-317 ◽  
Author(s):  
Takaaki Ikuno ◽  
Atsuro Nomura ◽  
Kenta Iyoki ◽  
Ayae Sugawara-Narutaki ◽  
Tatsuya Okubo ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Oxide Nanoparticles ◽  
Facile Synthesis ◽  
Hollow Mesoporous Silica
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