The preparation, drug loading and in vitro NIR photothermal-controlled release behavior of raspberry-like hollow polypyrrole microspheres

2015 ◽  
Vol 3 (47) ◽  
pp. 9186-9193 ◽  
Author(s):  
Jie Wang ◽  
Fuxing Lin ◽  
Jinxing Chen ◽  
Mozhen Wang ◽  
Xuewu Ge
Keyword(s):  
Controlled Release ◽  
Cancer Therapy ◽  
Drug Loading ◽  
Release Behavior ◽  
Templating Method ◽  
Therapy Effect

Raspberry-like hollow polypyrrole microspheres (H-PPy), which are prepared through a templating method, exhibit promising synergistic cancer therapy effect.

Controlled Release of Trimaterene from Poly(DL-Lactide-Co-Glycolide) Microspheres

1993 ◽  
Vol 331 ◽  
Author(s):  
Amy D. Ouellete ◽  
Nicholas A. Peppas
Keyword(s):  
Controlled Release ◽  
Drug Loading ◽  
Release Behavior ◽  
Release Rates ◽  
Diffusion Controlled ◽  
Order Of Magnitude ◽  
Lower Drug ◽  
Biphasic Release ◽  
Silicone Matrix

AbstractRelease of triamterene from 150–300 gm poly(DL-lactide-co-glycolide) (PLGA) microspheres was investigated in vitro as a function of lactic acid/glycolic acid (LA/GA) copolymer ratio and drug loading both with free microspheres and with microspheres embedded in a silicone matrix. Biphasic release consisting of diffusion controlled release followed by erosion controlled release corresponding to polymer degradation was observed in all samples. Drug release from PLGA 50:50 copolymer microspheres was three times faster than the release from PLGA 75:25 microspheres for the higher drug loading (20 wt%) and slightly faster for the lower drug loading (10 wt%). Release rates from spheres containing the higher drug loading were approximately one order of magnitude faster than release from spheres containing the lower drug loading for the same PLGA copolymer. The same qualitative results were observed for the spheres embedded in silicone matrices; however, the overall release was much slower. The results demonstrate that release behavior may be altered by changing LA/GA copolymer ratio, drug loading, and microsphere environment to obtain the desired release characteristics.

Plasmonic CuS nanodisk assembly based composite nanocapsules for NIR-laser-driven synergistic chemo-photothermal cancer therapy

2018 ◽  
Vol 6 (7) ◽  
pp. 1035-1043 ◽  
Author(s):  
Jian He ◽  
Lisha Ai ◽  
Xin Liu ◽  
Hao Huang ◽  
Yuebin Li ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Cancer Cells ◽  
Therapeutic Effects ◽  
Release Behavior ◽  
Sustained Drug Release ◽  
Drug Release Behavior ◽  
Nir Laser

The NIR-laser-driven plasmonic photothermal and sustained drug release behavior of CuS–PTX/SiO2 nanocapsules show great synergistic chemo-photothermal therapeutic effects on cancer cells in vitro and in vivo.

scholarly journals PREPARATION, CHARACTERISATION AND EVALUATION OF ROPINIROLE HYDROCHLORIDE LOADED CONTROLLED RELEASE MICROSPHERES USING SOLVENT EVAPORATION TECHNIQUE

2018 ◽  
Vol 10 (6) ◽  
pp. 57
Author(s):  
Koyel Kar ◽  
R. N. Pal ◽  
N. N. Bala
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Release Kinetics ◽  
Drug Loading ◽  
Solvent Evaporation ◽  
In Vitro Drug Release ◽  
Aqueous Solvent ◽  
Evaporation Technique ◽  
Ropinirole Hydrochloride

Objective: The major objective of the research work was to design, characterise and evaluate controlled release microspheres of ropinirole hydrochloride by using non-aqueous solvent evaporation technique to facilitate the delivery of the drug at a predetermined rate for a specific period of time.Methods: Ropinirole hydrochloride microspheres were prepared by using different low-density polymers such as eudragit RL 100, eudragit RS 100 and ethylcellulose either alone or in combination with the help of non-aqueous solvent evaporation technique. All the formulated microparticles were subjected to various evaluation parameters such as particle size analysis, micrometric properties, drug entrapment efficiency, percentage drug loading, percentage yield and in vitro drug release study. The compatibility of the drug and polymers was confirmed by physical compatibility study, fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and x-ray diffraction study (XRD). The formation of the most optimized batch of the microsphere (F12) was confirmed by scanning electron microscopy (SEM), DSC, FTIR, and XRD. In vitro drug release study and in vitro drug release kinetics study of the formulated microspheres were also carried out.Results: Drug-polymer compatibility studies performed with the help of FTIR and DSC indicated that there were no interactions. Results revealed that non-aqueous solvent evaporation technique was a suitable technique for the preparation of microspheres as most of the formulations were discrete, free-flowing and spherical in shape with a good yield of 55.67% to 80.09%, percentage drug loading of 35.52% to 94.50% and percentage drug entrapment efficiency of 36.24% to 95.07%. Different drug-polymer ratios, as well as the combination of polymers, played a significant role in the variation of over-all characteristics of formulations. Based on the data of various evaluation parameters such as particle size analysis, percentage drug loading, percentage drug entrapment, percentage yield, rheological studies and in vitro drug release characteristics, formulation F12 was found to fulfil the criteria of ideal controlled release drug delivery system. F12 showed controlled release till the 14th hour (97.99%) and its in vitro release kinetics was best explained by zero-order kinetics and followed Korsemeyer-Pappas model (Non-Fickian mechanism). SEM of F12 revealed the formation of spherical structures. The FTIR study of F12 confirmed the stable nature of ropinirole in the drug-loaded microspheres. DSC and XRD patterns showed that ropinirole hydrochloride was dispersed at the molecular level in the polymer matrix.Conclusion: The controlled release microparticles were successfully prepared and from this study, it was concluded that the developed microspheres of ropinirole hydrochloride can be used for controlled drug release to improve the bioavailability and patient compliance and to maintain a constant drug level in the blood target tissue by releasing the drug in zero order pattern.

Preparation and in vitro controlled release behavior of a novel pH-sensitive drug carrier for colon delivery

2008 ◽  
Vol 62 (2) ◽  
pp. 183-193 ◽  
Author(s):  
Dong-Ying Xu ◽  
Guang-Ji Li ◽  
Zheng-Fu Liao ◽  
Xiao-Hong He
Keyword(s):  
Controlled Release ◽  
Drug Carrier ◽  
Ph Sensitive ◽  
Release Behavior ◽  
Colon Delivery

Silicon-Nanowire-Based Nanocarriers with Ultrahigh Drug-Loading Capacity for In Vitro and In Vivo Cancer Therapy

2012 ◽  
Vol 125 (5) ◽  
pp. 1497-1501 ◽  
Author(s):  
Fei Peng ◽  
Yuanyuan Su ◽  
Xinpan Wei ◽  
Yimei Lu ◽  
Yanfeng Zhou ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Silicon Nanowire ◽  
Drug Loading ◽  
Loading Capacity

scholarly journals Sequential Drug Delivery By Injectable Macroporous Hydrogels For Combined Photodynamic-Chemotherapy

2021 ◽  
Author(s):  
Yuanyuan Zhong ◽  
Li Zhang ◽  
Shian Sun ◽  
Zhenghao Zhou ◽  
Yunsu Ma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Near Infrared ◽  
Early Stage ◽  
Drug Loading ◽  
Tumor Therapy ◽  
Sequential Release ◽  
Therapy Effect ◽  
Hollow Mesoporous Silica

Abstract With hollow mesoporous silica (hMSN) and injectable macroporous hydrogel (Gel) used as the internal and external drug-loading material respectively, a sequential drug delivery system DOX-CA4P@Gel was constructed, in which combretastatin A4 phosphate (CA4P) and doxorubicin (DOX) were both loaded. The anti-angiogenic drug, CA4P was initially released due to the degradation of Gel, followed by the anti-cell proliferative drug, DOX, released from hMSN in tumor microenvironment. Results showed that CA4P was mainly released at the early stage. At 48 h, CA4P release reached 71.08%, while DOX was only 14.39%. At 144 h, CA4P was 78.20%, while DOX release significantly increased to 61.60%, showing an obvious sequential release behavior. Photodynamic properties of porphyrin endow hydrogel (φΔ(Gel)=0.91) with enhanced tumor therapy effect. In vitro and in vivo experiments showed that dual drugs treated groups have better tumor inhibition than solo drug under near infrared laser irradiation, indicating the effectivity of combined photodynamic-chemotherapy.

Controlled Release of Doxycycline by Magnetized Microporous MIL53(Fe); Focus on Magnetization and Drug Loading

2018 ◽  
Vol 16 (1) ◽  
pp. 42-50 ◽  
Author(s):  
Shakiba Naeimi ◽  
Hossein Faghihian
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Loading ◽  
In Vitro Release ◽  
Time Intervals ◽  
Drug Content ◽  
Releasing Process ◽  
Phosphate Buffered Saline ◽  
Vitro Release

Background: In this research, MIL-53(Fe) was magnetized and the performance of the magnetized material as a drug delivery system for doxycycline was studied. Objectives: The experiments were designed to load the magnetic delivery compounds with different amount of the drug. Methods: The in vitro release rate of doxycycline from magnetic MIL-53(Fe) with different drug content into saline buffered fluid (SBF, pH=7.4) and phosphate buffered saline (PBS, pH=3) was then studied. Results: The results showed that the releasing process of the drug in PBS media achieved the equilibration within 48h with 98% of releasing efficiency, while the releasing process in SBF media (pH=7.4) was slower and the equilibrium was established within 264 h with the releasing efficiency of 95%. The amount of the released doxycycline from the samples with different drug content was measured at various time intervals. Conclusion: It was concluded that in PBS media after 75 h, 85, 95 and 98% of loaded doxycycline released, respectively, from the sample containing 22, 32 and 35% of the drug. In SBF media, the release was slower and after 350 h, 82, 91 and 95% of loaded doxycycline released from the samples, respectively, containing 22, 32 and 35 % of the drug. The results of this study indicated that by use of drugreleasing profile and selecting appropriate carrier dose, the released amount of the drug into the patient body can be controlled.

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