scholarly journals Hydrogels that allow and facilitate bone repair, remodeling, and regeneration

2015 ◽  
Vol 3 (40) ◽  
pp. 7818-7830 ◽  
Author(s):  
Aaron R. Short ◽  
Deepthi Koralla ◽  
Ameya Deshmukh ◽  
Benjamin Wissel ◽  
Benjamin Stocker ◽  
...  
Keyword(s):  
Gold Standard ◽  
Bone Repair ◽  
Standard Treatment ◽  
Bone Grafts ◽  
Bone Defects ◽  
Surgical Reconstruction ◽  
Congenital Deformity ◽  
Bone Stock ◽  
Autologous Bone ◽  
Autologous Bone Grafts

Bone defects can originate from a variety of causes, including trauma, cancer, congenital deformity, and surgical reconstruction. Success of the current “gold standard” treatment (i.e., autologous bone grafts) is greatly influenced by insufficient or inappropriate bone stock.

Combined use of platelet-rich plasma and autologous bone grafts in the treatment of long bone defects in mini-pigs

Injury ◽  
2010 ◽  
Vol 41 (7) ◽  
pp. 717-723 ◽  
Author(s):  
M. Hakimi ◽  
P. Jungbluth ◽  
M. Sager ◽  
M. Betsch ◽  
M. Herten ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Bone Grafts ◽  
Bone Defects ◽  
Long Bone ◽  
Combined Use ◽  
Autologous Bone ◽  
Autologous Bone Grafts ◽  
Mini Pigs

scholarly journals Autologous bone grafts with MSCs or FGF-2 accelerate bone union in large bone defects

2016 ◽  
Vol 11 (1) ◽  
Author(s):  
Hiroaki Murakami ◽  
Tomoyuki Nakasa ◽  
Masakazu Ishikawa ◽  
Nobuo Adachi ◽  
Mitsuo Ochi
Keyword(s):  
Bone Grafts ◽  
Bone Defects ◽  
Bone Union ◽  
Autologous Bone ◽  
Autologous Bone Grafts ◽  
Large Bone ◽  
Large Bone Defects

scholarly journals Osteoinductive 3D Printed Scaffold Healed 5 cm Segmental Bone Defects in the Ovine Metatarsus

2020 ◽  
Author(s):  
Yunzhi Peter Yang ◽  
Kevin Labus ◽  
Benjamin Gadomski ◽  
Arnaud Bruyas ◽  
Jeremiah Easley ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Large Scale ◽  
Composite Scaffold ◽  
Bone Grafts ◽  
Bone Defects ◽  
Collagen Sponge ◽  
Bone Morphogenetic Protein 2 ◽  
3D Printed ◽  
Autologous Bone ◽  
Autologous Bone Grafts

Abstract Autologous bone grafts are considered the gold standard grafting material for the treatment of nonunion, but in very large bone defects, traditional autograft alone is insufficient to induce repair. Recombinant human bone morphogenetic protein 2 (rhBMP-2) can stimulate bone regeneration and enhance the healing efficacy of bone grafts. The delivery of rhBMP-2 may even enable engineered synthetic scaffolds to be used in place of autologous bone grafts for the treatment of critical size defects, eliminating risks associated with autologous tissue harvest. We here demonstrate that an osteoinductive scaffold, fabricated by combining a 3D printed rigid polymer/ceramic composite scaffold with an rhBMP-2-eluting collagen sponge can treat extremely large-scale segmental defects in the sheep metatarsus. Bone regeneration after 24 weeks was evaluated by micro-computed tomography, mechanical testing, and histological characterization. Load-bearing cortical bridging was achieved in all animals, with increased bone volume observed in sheep that received osteoinductive scaffolds compared to sheep that received an rhBMP-2-eluting collagen sponge alone.

scholarly journals Osteoinductive 3D printed scaffold healed 5 cm segmental bone defects in the ovine metatarsus

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yunzhi Peter Yang ◽  
Kevin M. Labus ◽  
Benjamin C. Gadomski ◽  
Arnaud Bruyas ◽  
Jeremiah Easley ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Large Scale ◽  
Composite Scaffold ◽  
Bone Grafts ◽  
Bone Defects ◽  
Collagen Sponge ◽  
Bone Morphogenetic Protein 2 ◽  
3D Printed ◽  
Autologous Bone ◽  
Autologous Bone Grafts

AbstractAutologous bone grafts are considered the gold standard grafting material for the treatment of nonunion, but in very large bone defects, traditional autograft alone is insufficient to induce repair. Recombinant human bone morphogenetic protein 2 (rhBMP-2) can stimulate bone regeneration and enhance the healing efficacy of bone grafts. The delivery of rhBMP-2 may even enable engineered synthetic scaffolds to be used in place of autologous bone grafts for the treatment of critical size defects, eliminating risks associated with autologous tissue harvest. We here demonstrate that an osteoinductive scaffold, fabricated by combining a 3D printed rigid polymer/ceramic composite scaffold with an rhBMP-2-eluting collagen sponge can treat extremely large-scale segmental defects in a pilot feasibility study using a new sheep metatarsus fracture model stabilized with an intramedullary nail. Bone regeneration after 24 weeks was evaluated by micro-computed tomography, mechanical testing, and histological characterization. Load-bearing cortical bridging was achieved in all animals, with increased bone volume observed in sheep that received osteoinductive scaffolds compared to sheep that received an rhBMP-2-eluting collagen sponge alone.

Ethylene oxide gas sterilization: a simple technique for storing explanted skull bone

2007 ◽  
Vol 107 (2) ◽  
pp. 440-445 ◽  
Author(s):  
David H. Jho ◽  
Sergey Neckrysh ◽  
Julian Hardman ◽  
Fady T. Charbel ◽  
Sepideh Amin-Hanjani
Keyword(s):  
Ethylene Oxide ◽  
Decompressive Craniectomy ◽  
Room Temperature ◽  
Simple Technique ◽  
Functional Results ◽  
Bone Grafts ◽  
Increased Risk ◽  
Autologous Bone ◽  
Autologous Bone Grafts

✓ The authors evaluated the effectiveness of a simple technique using ethylene oxide (EtO) gas sterilization and room temperature storage of autologous bone grafts for reconstructive cranioplasty following decompressive craniectomy. The authors retrospectively analyzed data in 103 consecutive patients who underwent cranioplasty following decompressive craniectomy for any cause at the University of Illinois at Chicago between 1999 and 2005. Patients with a pre-existing intracranial infection prior to craniectomy or lost to follow-up before reconstruction were excluded. Autologous bone grafts were cleansed of soft tissue, hermetically sealed in sterilization pouches for EtO gas sterilization, and stored at room temperature until reconstructive cranioplasty was performed. Cranioplasties were performed an average of 4 months after decompressive craniectomy, and the follow-up after reconstruction averaged 14 months. Excellent aesthetic and functional results after single-stage reconstruction were achieved in 95 patients (92.2%) as confirmed on computed tomography. An infection of the bone flap occurred in eight patients (7.8%), and the skull defects were eventually reconstructed using polymethylmethacrylate with satisfactory results. The mean preservation interval was 3.8 months in patients with uninfected flaps and 6.4 months in those with infected flaps (p = 0.02). A preservation time beyond 10 months was associated with a significantly increased risk of flap infection postcranioplasty (odds ratio [OR] 10.8, p = 0.02). Additionally, patients who had undergone multiple craniotomies demonstrated a trend toward increased infection rates (OR 3.0, p = 0.13). Data in this analysis support the effectiveness of this method, which can be performed at any institution that provides EtO gas sterilization services. The findings also suggest that bone flaps preserved beyond 10 months using this technique should be discarded or resterilized prior to reconstruction.

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