Glucose-induced decomposition of layer-by-layer films composed of phenylboronic acid-bearing poly(allylamine) and poly(vinyl alcohol) under physiological conditions

2015 ◽  
Vol 3 (39) ◽  
pp. 7796-7802 ◽  
Author(s):  
Katsuhiko Sato ◽  
Mao Takahashi ◽  
Megumi Ito ◽  
Eiichi Abe ◽  
Jun-Ichi Anzai
Keyword(s):  
Glucose Oxidase ◽  
Vinyl Alcohol ◽  
Phenylboronic Acid ◽  
Poly Vinyl Alcohol ◽  
Layer By Layer ◽  
Physiological Conditions ◽  
Induced Decomposition

Phenylboronic acid-bearing poly(allylamine)/poly(vinyl alcohol) layer-by-layer films coupled with glucose oxidase decomposed in the presence of glucose under physiological conditions.

H2O2-Induced Decomposition of Layer-by-Layer Films Consisting of Phenylboronic Acid-Bearing Poly(allylamine) and Poly(vinyl alcohol)

Langmuir ◽  
2014 ◽  
Vol 30 (31) ◽  
pp. 9247-9250 ◽  
Author(s):  
Katsuhiko Sato ◽  
Mao Takahashi ◽  
Megumi Ito ◽  
Eiichi Abe ◽  
Jun-ichi Anzai
Keyword(s):  
Vinyl Alcohol ◽  
Phenylboronic Acid ◽  
Poly Vinyl Alcohol ◽  
Layer By Layer ◽  
Induced Decomposition

scholarly journals Adsorption and Release of Rose Bengal on Layer-by-Layer Films of Poly(Vinyl Alcohol) and Poly(Amidoamine) Dendrimers Bearing 4-Carboxyphenylboronic Acid

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1854 ◽  
Author(s):  
Kentaro Yoshida ◽  
Akane Yamaguchi ◽  
Hiroki Midorikawa ◽  
Toshio Kamijo ◽  
Tetsuya Ono ◽  
...  
Keyword(s):  
Rose Bengal ◽  
Boronic Acid ◽  
Vinyl Alcohol ◽  
Acidic Solution ◽  
Phenylboronic Acid ◽  
Poly Vinyl Alcohol ◽  
Basic Solution ◽  
Layer By Layer ◽  
Lbl Films ◽  
H2o2 Solution

Phenylboronic acid-bearing polyamidoamine dendrimer (PBA-PAMAM)/poly(vinyl alcohol) (PVA) multilayer films were prepared through the layer-by-layer (LbL) deposition of PBA-PAMAM solution and PVA solution. PBA-PAMAM/PVA films were constructed successfully through the formation of boronate ester bonds between the boronic acid moiety in PBA and 1,3-diol units in PVA. When the (PBA-PAMAM/PVA)5 films were immersed in rose bengal (RB) solution, RB was adsorbed onto the LbL films. The amount of RB adsorbed was higher in the LbL films immersed in acidic solution than in basic solution. The release of RB from the LbL films was also promoted in the basic solution, while it was suppressed in the acidic solution. The boronic acid ester is oxidized to phenol by hydrogen peroxide (H2O2) and the carbon-boron bond is cleaved, so that the (PBA-PAMAM/PVA)5 films can be decomposed by immersion in H2O2 solution. Therefore, when RB-adsorbed (PBA-PAMAM/PVA)5 films were immersed in H2O2 solution, the release of RB was moderately promoted when the solution was weakly acidic.

scholarly journals Sugar-Responsive Layer-by-Layer Film Composed of Phenylboronic Acid-Appended Insulin and Poly(vinyl alcohol)

2018 ◽  
Vol 66 (4) ◽  
pp. 368-374 ◽  
Author(s):  
Chihiro Takei ◽  
Yui Ohno ◽  
Tomohiro Seki ◽  
Ryotaro Miki ◽  
Toshinobu Seki ◽  
...  
Keyword(s):  
Vinyl Alcohol ◽  
Phenylboronic Acid ◽  
Poly Vinyl Alcohol ◽  
Layer By Layer ◽  
Layer Film

scholarly journals Decomposition of Glucose-Sensitive Layer-by-Layer Films Using Hemin, DNA, and Glucose Oxidase

Polymers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 319 ◽  
Author(s):  
Kentaro Yoshida ◽  
Yu Kashimura ◽  
Toshio Kamijo ◽  
Tetsuya Ono ◽  
Takenori Dairaku ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Glucose Oxidase ◽  
Dna Cleavage ◽  
Electrostatic Interactions ◽  
Glucose Solution ◽  
Layer By Layer ◽  
Sensitive Layer ◽  
Physiological Conditions ◽  
Lbl Films ◽  
Low Glucose

Glucose-sensitive films were prepared through the layer-by-layer (LbL) deposition of hemin-modified poly(ethyleneimine) (H-PEI) solution and DNA solution (containing glucose oxidase (GOx)). H-PEI/DNA + GOx multilayer films were constructed using electrostatic interactions. The (H-PEI/DNA + GOx)5 film was then partially decomposed by hydrogen peroxide (H2O2). The mechanism for the decomposition of the LbL film was considered to involve more reactive oxygen species (ROS) that were formed by the reaction of hemin and H2O2, which then caused nonspecific DNA cleavage. In addition, GOx present in the LbL films reacts with glucose to generate hydrogen peroxide. Therefore, decomposition of the (H-PEI/DNA + GOx)5 film was observed when the thin film was immersed in a glucose solution. (H-PEI/DNA + GOx)5 films exposed to a glucose solution for periods of 24, 48 72, and 96 h indicated that the decomposition of the film increased with the time to 9.97%, 16.3%, 23.1%, and 30.5%, respectively. The rate of LbL film decomposition increased with the glucose concentration. At pH and ionic strengths close to physiological conditions, it was possible to slowly decompose the LbL film at low glucose concentrations of 1–10 mM.

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