scholarly journals Preparation and characterization of double macromolecular network (DMMN) hydrogels based on hyaluronan and high molecular weight poly(ethylene glycol)

2015 ◽  
Vol 3 (32) ◽  
pp. 6618-6625 ◽  
Author(s):  
Changjiang Fan ◽  
Chao Zhang ◽  
Liqiong Liao ◽  
Sheng Li ◽  
Weiping Gan ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Ethylene Glycol ◽  
Network Structure ◽  
Polymer Network ◽  
Poly Ethylene Glycol ◽  
Double Network ◽  
Macromolecular Network ◽  
Poly Ethylene ◽  
High Molecular Weight Poly

Ultra-strong and resilient double macromolecular network (DMMN) hydrogels with a more evenly distributed polymer network and a double-network structure have been developed.

Hydrolytically and Reductively Degradable High-Molecular-Weight Poly(ethylene glycol)s

2007 ◽  
Vol 208 (24) ◽  
pp. 2642-2653 ◽  
Author(s):  
Alena Braunová ◽  
Michal Pechar ◽  
Richard Laga ◽  
Karel Ulbrich
Keyword(s):  
Molecular Weight ◽  
Ethylene Glycol ◽  
High Molecular Weight ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
High Molecular Weight Poly

scholarly journals Some Guidelines for the Synthesis and Melting Characterization of Azide Poly(ethylene glycol) Derivatives

Polymers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1269
Author(s):  
Daniel González-Fernández ◽  
Mercedes Torneiro ◽  
Massimo Lazzari
Keyword(s):  
Molecular Weight ◽  
Ethylene Glycol ◽  
Average Molecular Weight ◽  
Size Exclusion ◽  
Degree Of Crystallinity ◽  
Specific Class ◽  
Poly Ethylene Glycol ◽  
End Groups ◽  
Poly Ethylene

We provide fundamental guidelines in the form of a tutorial to be taken into account for the preparation and characterization of a specific class of poly(ethylene glycol) (PEG) derivatives, namely azide-terminated PEGs. Special attention is given to the effect of these chain end groups and their precursors on properties affecting the PEGylation of proteins, nanoparticles and nanostructured surfaces. Notwithstanding the presence of 13C satellite peaks, we show that 1H NMR enables not only the routine quantitative determination of chain-end substitution, but is also a unique method to calculate the absolute number average molecular weight of PEG derivatives. In the use of size exclusion chromatography to get molecular weight distributions, we highlight the importance of distinguishing between eventual secondary reactions involving molecular weight changes and the formation of PEG complexes due to residual amounts of metal cations from reactants. Finally, we show that azide end groups affect PEG melting behavior. In contrast to oxygen-containing end groups, azides do not interact with PEG segments, thus inducing defect formation in the crystal lattice and the reduction of crystal sizes. Melting temperature and degree of crystallinity decrease become especially relevant for PEGs with very low molecular weight, and its comprehension is particularly important for solid-state applications.

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