Disulfide-gated mesoporous silica nanoparticles designed for two-photon-triggered drug release and imaging

2015 ◽  
Vol 3 (31) ◽  
pp. 6456-6461 ◽  
Author(s):  
Jonas G. Croissant ◽  
Christian Qi ◽  
Olivier Mongin ◽  
Vincent Hugues ◽  
Mireille Blanchard-Desce ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cell ◽  
Mesoporous Silica Nanoparticles ◽  
Cell Killing ◽  
Two Photon ◽  
Triggered Drug Release

We report two-photon cancer cell killing through mesoporous silica nanogates.

scholarly journals Bioresponsive Mesoporous Silica Nanoparticles for Triggered Drug Release

2011 ◽  
Vol 133 (49) ◽  
pp. 19582-19585 ◽  
Author(s):  
Neetu Singh ◽  
Amrita Karambelkar ◽  
Luo Gu ◽  
Kevin Lin ◽  
Jordan S. Miller ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Triggered Drug Release

Light-Triggered Drug Release Platform Based on Superhydrophobicity of Mesoporous Silica Nanoparticles

2016 ◽  
Vol 8 (5) ◽  
pp. 428-433 ◽  
Author(s):  
Wanyuan Gui ◽  
Junpin Lin ◽  
Guojian Hao ◽  
Yongfeng Liang ◽  
Wenqian Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Triggered Drug Release

scholarly journals pH-Triggered Drug Release Controlled by Poly(Styrene Sulfonate) Growth Hollow Mesoporous Silica Nanoparticles

ACS Omega ◽  
2020 ◽  
Vol 5 (8) ◽  
pp. 4261-4269 ◽  
Author(s):  
Fajar R. Wibowo ◽  
Ozi A. Saputra ◽  
Witri W. Lestari ◽  
Mamoru Koketsu ◽  
Rino R. Mukti ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Styrene Sulfonate ◽  
Triggered Drug Release ◽  
Hollow Mesoporous Silica ◽  
Poly Styrene Sulfonate

Heat-triggered drug release systems based on mesoporous silica nanoparticles filled with a maghemite core and phase-change molecules as gatekeepers

2014 ◽  
Vol 2 (1) ◽  
pp. 59-70 ◽  
Author(s):  
Ji Liu ◽  
Christophe Detrembleur ◽  
Marie-Claire De Pauw-Gillet ◽  
Stéphane Mornet ◽  
Luce Vander Elst ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Phase Change ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Triggered Drug Release

Protamine-Capped Mesoporous Silica Nanoparticles for Biologically Triggered Drug Release

2013 ◽  
Vol 31 (4) ◽  
pp. 449-458 ◽  
Author(s):  
Krishna Radhakrishnan ◽  
Satyajit Gupta ◽  
Divya Prakash Gnanadhas ◽  
Praveen C. Ramamurthy ◽  
Dipshika Chakravortty ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Triggered Drug Release

Mesoporous silica nanoparticles-based stimuli-triggered drug release systems

2022 ◽  
pp. 237-264
Author(s):  
Rajesh Salve ◽  
Pramod Kumar ◽  
Kavita R. Gajbhiye ◽  
Rajnigandha A. Shende ◽  
Bhushan P. Chaudhari ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Triggered Drug Release

scholarly journals Ultrasound-Responsive Smart Drug Delivery System of Lipid Coated Mesoporous Silica Nanoparticles

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1396
Author(s):  
Muhammad Umair Amin ◽  
Sajid Ali ◽  
Imran Tariq ◽  
Muhammad Yasir Ali ◽  
Shashank Reddy Pinnapreddy ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Cellular Uptake ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Triggered Drug Release ◽  
Premature Release

The immediate release of chemotherapeutics at the target site, along with no premature release in circulation is always challenging. The purpose of this study was to develop a stimuli responsive drug delivery system, composed of lipid supported mesoporous silica nanoparticles (MSNPs) for triggered drug release at the target site and simultaneously avoiding the premature release. MSNPs with a higher drug loading capacity and very slow release were designed so as to enhance release by FDA approved US-irradiation. Doxorubicin, as a model drug, and perfluoropentane (PFP) as a US responsive material, were entrapped in the porous structure of MSNPs. Lipid coating enhanced the cellular uptake and in addition provided a gatekeeping effect at the pore opening to reduce premature release. The mechanical and thermal effects of US induced the conversion of liquid PFP to a gaseous form that was able to rupture the lipid layer, resulting in triggered drug release. The prolonged stability profile and non-toxic behavior made them suitable candidate for the delivery of anticancer drugs. This smart system, with the abilities of better cellular uptake and higher cytotoxic effects on US-irradiation, would be a good addition to the applied side of chemotherapeutic advanced drug delivery systems.

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