Synthesis of magnetic Fe3O4–Au hybrids for sensitive SERS detection of cancer cells at low abundance

2015 ◽  
Vol 3 (22) ◽  
pp. 4487-4495 ◽  
Author(s):  
Yanchun Qiu ◽  
Dan Deng ◽  
Qianwen Deng ◽  
Ping Wu ◽  
Hui Zhang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Hybrid Nanoparticles ◽  
Sers Detection ◽  
Magnetic Fe3o4

A facile and rapid SERS-based immunoassay for living cancer cells using magnetic Fe3O4–Au hybrid nanoparticles is reported.

Inorganic nanoparticles for the theranostics of cancer

2015 ◽  
Vol 7 (4) ◽  
Author(s):  
Jyoti Verma ◽  
Sumit Lal ◽  
Cornelis J.F. Van Noorden
Keyword(s):  
Cancer Cells ◽  
Patient Survival ◽  
Early Stage ◽  
Cancer Diagnostics ◽  
Inorganic Nanoparticles ◽  
Hybrid Nanoparticles ◽  
Early Stage Cancer ◽  
Organic Shell ◽  
Clinical Advances

AbstractTheranostics are a multifunctional approach using nanoparticles for combined diagnostic and therapeutic purposes. The hybrid nanoparticles that are applied for these purposes are composed of an inorganic core and an organic shell. The inorganic core acts as a contrast enhancer and the organic shell acts as a drug releaser. Hybrid nanoparticles can be conjugated with targeting moieties and systematically administered to patients to direct the nanoparticles to specific cells such as cancer cells. Theranostics have the potential to significantly improve early stage cancer diagnostics and patient survival. This review discusses preclinical and clinical advances in applications of inorganic nanoparticles for the theranostics of cancer.

scholarly journals Dual Targeting of Cancer Cells and MMPs with Self-Assembly Hybrid Nanoparticles for Combination Therapy in Combating Cancer

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 1990
Author(s):  
Kai Zhang ◽  
Jingjing Li ◽  
Xiaofei Xin ◽  
Xiaoqing Du ◽  
Di Zhao ◽  
...  
Keyword(s):  
T Cells ◽  
Cancer Cells ◽  
Self Assembly ◽  
Chemotherapeutic Agents ◽  
Hybrid Nanoparticles ◽  
Control Group ◽  
Hyperthermia Treatment ◽  
Immune Modulators ◽  
Dual Targeting

The co-delivery of chemotherapeutic agents and immune modulators to their targets remains to be a great challenge for nanocarriers. Here, we developed a hybrid thermosensitive nanoparticle (TMNP) which could co-deliver paclitaxel-loaded transferrin (PTX@TF) and marimastat-loaded thermosensitive liposomes (MMST/LTSLs) for the dual targeting of cancer cells and the microenvironment. TMNPs could rapidly release the two payloads triggered by the hyperthermia treatment at the site of tumor. The released PTX@TF entered cancer cells via transferrin-receptor-mediated endocytosis and inhibited the survival of tumor cells. MMST was intelligently employed as an immunomodulator to improve immunotherapy by inhibiting matrix metalloproteinases to reduce chemokine degradation and recruit T cells. The TMNPs promoted the tumor infiltration of CD3+ T cells by 2-fold, including memory/effector CD8+ T cells (4.2-fold) and CD4+ (1.7-fold), but not regulatory T cells. Our in vivo anti-tumor experiment suggested that TMNPs possessed the highest tumor growth inhibitory rate (80.86%) compared with the control group. We demonstrated that the nanoplatform could effectively inhibit the growth of tumors and enhance T cell recruitment through the co-delivery of paclitaxel and marimastat, which could be a promising strategy for the combination of chemotherapy and immunotherapy for cancer treatment.

Novel lipid-polymer hybrid nanoparticles for siRNA delivery and IGF-1R gene silencing in breast cancer cells

2018 ◽  
Vol 48 ◽  
pp. 96-105 ◽  
Author(s):  
Hannaneh monirinasab ◽  
Hamed Asadi ◽  
Kobra Rostamizadeh ◽  
Abdolreza Esmaeilzadeh ◽  
Malihe Khodaei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Silencing ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Sirna Delivery ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid

Overcoming the diverse mechanisms of multidrug resistance in lung cancer cells by photodynamic therapy using pTHPP-loaded PLGA-lipid hybrid nanoparticles

2020 ◽  
Vol 149 ◽  
pp. 218-228 ◽  
Author(s):  
Sasivimon Pramual ◽  
Kriengsak Lirdprapamongkol ◽  
Valérie Jouan-Hureaux ◽  
Muriel Barberi-Heyob ◽  
Céline Frochot ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Photodynamic Therapy ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Hybrid Nanoparticles

Killing cancer cells using nanotechnology: novel poly(I:C) loaded liposome–silica hybrid nanoparticles

2015 ◽  
Vol 3 (37) ◽  
pp. 7408-7416 ◽  
Author(s):  
Valentina Colapicchioni ◽  
Sara Palchetti ◽  
Daniela Pozzi ◽  
Elettra Sara Marini ◽  
Anna Riccioli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Hybrid Nanoparticles ◽  
Poly I:C ◽  
Core Shell ◽  
Polycytidylic Acid ◽  
Anti Cancer ◽  
Polyinosinic Polycytidylic Acid ◽  
Silica Hybrid

Synthesized core–shell liposome–silica hybrid nanoparticles (LSH NPs), when loaded with the anti-cancer polyinosinic–polycytidylic acid (poly(I:C)), exhibit high anti-tumoral activity in prostate and breast cancer cells.

scholarly journals Albumin-Modified Melanin-Silica Hybrid Nanoparticles Target Breast Cancer Cells via a SPARC-Dependent Mechanism

2020 ◽  
Vol 8 ◽  
Author(s):  
Gennaro Sanità ◽  
Paolo Armanetti ◽  
Brigida Silvestri ◽  
Barbara Carrese ◽  
Gaetano Calì ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Hybrid Nanoparticles ◽  
Silica Hybrid ◽  
Dependent Mechanism
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