Ultra-high relaxivity iron oxide nanoparticles confined in polymer nanospheres for tumor MR imaging

2015 ◽  
Vol 3 (28) ◽  
pp. 5702-5710 ◽  
Author(s):  
Ying Lin ◽  
Sanxi Wang ◽  
Yajun Zhang ◽  
Jiangang Gao ◽  
Liu Hong ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Contrast Agent ◽  
Iron Oxide Nanoparticles ◽  
Mri Contrast Agent ◽  
Oxide Nanoparticles ◽  
Hydrophilic Polymer ◽  
Mri Contrast ◽  
High Relaxivity ◽  
Polymer Nanospheres

An ultra-high relaxivity of MRI contrast agent was fabricated by controlling the clustering of iron oxide nanoparticles confined in a hydrophilic polymer.

scholarly journals High Transverse Relaxivity and Anticancer Agent Loading/Release Characteristics of Porous Calcium Phosphate Coated Iron Oxide Nanoparticles

2020 ◽  
Vol 11 (3) ◽  
pp. 10402-10411
Keyword(s):  
Iron Oxide ◽  
Calcium Phosphate ◽  
Contrast Agent ◽  
Iron Oxide Nanoparticles ◽  
Mri Contrast Agents ◽  
Mri Contrast Agent ◽  
Oxide Nanoparticles ◽  
Mri Contrast ◽  
Cell Compatibility ◽  
High Relaxivity

High relaxivity of MRI contrast agents leads to considerable contrast enhancement in the images and provides diagnostic accuracy. The purpose of the current study was to design a potential MRI contrast agent with a high relaxivity and investigate its curcumin loading/release property. To achieve this purpose, we synthesized the porous calcium phosphate coated iron oxide nanoparticles using a facile method and determined the physicochemical characteristics, cell compatibility effect, transverse relaxivity, and curcumin loading/release properties of the nanoparticles. The results indicated the spherical nanoparticles with a size of 10-20 nm. The nanoparticles demonstrated a superparamagnetic property and a high transverse relaxivity of 845.71 mM-1S-1. Although the porous calcium phosphate coated iron oxide nanoparticles were highly cytocompatible, the curcumin loaded nanoparticles showed a considerable effect on the bone marrow stem cells viability. In conclusion, the porous calcium phosphate coated iron oxide nanoparticles have the potential to introduce as a negative contrast agent of MRI with the ability of slow release of curcumin.

Iron oxide nanoparticles for use as an MRI contrast agent: Pharmacokinetics and metabolism

1991 ◽  
Vol 9 (3) ◽  
pp. 275-283 ◽  
Author(s):  
D. Pouliquen ◽  
J.J. Le Jeune ◽  
R. Perdrisot ◽  
A. Ermias ◽  
P. Jallet
Keyword(s):  
Iron Oxide ◽  
Contrast Agent ◽  
Iron Oxide Nanoparticles ◽  
Mri Contrast Agent ◽  
Oxide Nanoparticles ◽  
Mri Contrast

scholarly journals Iron oxide nanoparticles stabilized with dendritic polyglycerols as selective MRI contrast agents

Nanoscale ◽  
2014 ◽  
Vol 6 (16) ◽  
pp. 9646-9654 ◽  
Author(s):  
Daniel Nordmeyer ◽  
Patrick Stumpf ◽  
Dominic Gröger ◽  
Andreas Hofmann ◽  
Sven Enders ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Iron Oxide ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Mri Contrast Agents ◽  
Mri Contrast Agent ◽  
Oxide Nanoparticles ◽  
Mri Contrast

Superparamagnetic iron oxide nanoparticles with a dendritic polyglycerol (dPG) sulfate strongly bind to L- and P-selectin. Shielding of leukocytes reduces cell extravasation and binding to endothelial cells indicate inflammation specificity and thus, applicability as selective MRI contrast agent.

scholarly journals Synthesis and characterization of PVP-coated large core iron oxide nanoparticles as an MRI contrast agent

2008 ◽  
Vol 19 (16) ◽  
pp. 165101 ◽  
Author(s):  
Ha-Young Lee ◽  
Sang-Hoon Lee ◽  
Chenjie Xu ◽  
Jin Xie ◽  
Jin-Hyung Lee ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agent ◽  
Iron Oxide Nanoparticles ◽  
Mri Contrast Agent ◽  
Synthesis And Characterization ◽  
Oxide Nanoparticles ◽  
Large Core ◽  
Mri Contrast
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