Integrating dye-intercalated DNA dendrimers with electrospun nanofibers: a new fluorescent sensing platform for nucleic acids, proteins, and cells

2015 ◽  
Vol 3 (17) ◽  
pp. 3541-3547 ◽  
Author(s):  
Huaming Wang ◽  
Wei Tang ◽  
Hejia Wei ◽  
Yan Zhao ◽  
Shichao Hu ◽  
...  

A fluorescent dye-intercalated DNA dendrimer probe was integrated with electrospun nanofibers to create an amplified sensing platform for disease-related species.

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Anna Kanegae ◽  
Yusuke Takata ◽  
Ippei Takashima ◽  
Shohei Uchinomiya ◽  
Ryosuke Kawagoe ◽  
...  

AbstractDespite continuous and active development of fluorescent metal-ion probes, their molecular design for ratiometric detection is restricted by the limited choice of available sensing mechanisms. Here we present a multicolor and ratiometric fluorescent sensing platform for metal ions based on the interaction between the metal ion and the aromatic ring of a fluorophore (arene–metal-ion, AM, coordination). Our molecular design provided the probes possessing a 1,9-bis(2′-pyridyl)-2,5,8-triazanonane as a flexible metal ion binding unit attached to a tricyclic fluorophore. This architecture allows to sense various metal ions, such as Zn(II), Cu(II), Cd(II), Ag(I), and Hg(II) with emission red-shifts. We showed that this probe design is applicable to a series of tricyclic fluorophores, which allow ratiometric detection of the metal ions from the blue to the near-infrared wavelengths. X-ray crystallography and theoretical calculations indicate that the coordinated metal ion has van der Waals contact with the fluorophore, perturbing the dye’s electronic structure and ring conformation to induce the emission red-shift. A set of the probes was useful for the differential sensing of eight metal ions in a one-pot single titration via principal component analysis. We also demonstrate that a xanthene fluorophore is applicable to the ratiometric imaging of metal ions under live-cell conditions.


2013 ◽  
Vol 41 ◽  
pp. 442-445 ◽  
Author(s):  
Rong Hu ◽  
Ya-Ru Liu ◽  
Xiao-Bing Zhang ◽  
Weihong Tan ◽  
Guo-Li Shen ◽  
...  

2018 ◽  
Vol 90 (24) ◽  
pp. 14507-14513 ◽  
Author(s):  
Lili Tong ◽  
Xiuxiu Wang ◽  
Wen Gao ◽  
Zhenhua Liu ◽  
Zhenzhen Chen ◽  
...  

2019 ◽  
Vol 11 (39) ◽  
pp. 35622-35629 ◽  
Author(s):  
Fan Chang ◽  
Lijun Huang ◽  
Chaozhong Guo ◽  
Guoming Xie ◽  
Jiaqiang Li ◽  
...  

2019 ◽  
Vol 7 (1) ◽  
pp. 46-52 ◽  
Author(s):  
Bingqing Wang ◽  
Meiting Zhao ◽  
Liuxiao Li ◽  
Ying Huang ◽  
Xiao Zhang ◽  
...  

Abstract Structure engineering of metal-organic frameworks (MOFs) at the nanometer scale is attracting increasing interest due to their unique properties and new functions that normally cannot be achieved in bulk MOF crystals. Here, we report the preparation of ultra-thin MOF nanoribbons (NRBs) by using metal-hydroxide nanostructures as the precursors. Importantly, this general method can be used to synthesize various kinds of ultra-thin MOF NRBs, such as MBDC (M = Co, Ni; BDC = 1,4-benzenedicarboxylate), NiCoBDC, CoTCPP (TCPP = tetrakis(4-carboxyphenyl)porphyrin) and MIL-53(Al) NRBs. As a proof-of-concept application, the as-prepared ultra-thin CoBDC NRBs have been successfully used as a fluorescent sensing platform for DNA detection, which exhibited excellent sensitivity and selectivity. The present strategy might open an avenue to prepare MOF nanomaterials with new structures and unique properties for various promising applications.


2021 ◽  
Vol 404 ◽  
pp. 124015 ◽  
Author(s):  
Lu Li ◽  
Shuang Gao ◽  
Liu Yang ◽  
Yu-Long Liu ◽  
Ping Li ◽  
...  

2019 ◽  
Vol 43 (4) ◽  
pp. 1812-1817 ◽  
Author(s):  
Yang Li ◽  
Zhicheng Liu ◽  
Lu Bai ◽  
Yaqing Liu

Nitrogen-doped carbon dots were synthesized via the chemical breakdown of electrospun polyacrylonitrile-based carbon nanofibers and employed as a fluorescent sensing platform.


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