Synergistic mediation of tumor signaling pathways in hepatocellular carcinoma therapy via dual-drug-loaded pH-responsive electrospun fibrous scaffolds

2015 ◽  
Vol 3 (17) ◽  
pp. 3436-3446 ◽  
Author(s):  
Ziming Yuan ◽  
Xin Zhao ◽  
Jingwen Zhao ◽  
Guoqing Pan ◽  
Wangwang Qiu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Release ◽  
Cancer Drug ◽  
Ph Responsive ◽  
Short Term ◽  
Fibrous Scaffold ◽  
Anti Cancer ◽  
Anti Inflammation ◽  
Dual Drug

A novel pH-sensitive electrospun composite PLLA fibrous scaffold was developed with long-term anti-cancer drug release and short-term anti-inflammation drug release for liver cancer therapy.

scholarly journals Mechanochemical Approaches Towards the in Situ Confinement of 5-FU Anti-Cancer Drug Within MIL-100 (Fe) Metal-Organic Framework

2020 ◽  
Author(s):  
Barbara Souza ◽  
Jin-Chong Tan
Keyword(s):  
Drug Release ◽  
Metal Organic Framework ◽  
Cancer Drug ◽  
One Pot ◽  
Host Interactions ◽  
Anti Cancer ◽  
Metal Organic ◽  
Iron Based ◽  
Organic Framework

We report two solvent-free mechanochemical methods to achieve one‑pot encapsulation of anti-cancer drug 5‑Fluorouracil (5‑FU) in the iron-based MIL‑100 metal-organic framework (MOF). We compare the structural and physicochemical properties of drug@MIL‑100 systems derived from <i>in situ </i>manual and vortex grinding, where the former exhibits a slower drug release due to stronger guest-host interactions.

scholarly journals Modeling of Anti-Cancer Drug Release Kinetics From Liposomes and Micelles: A Review

2021 ◽  
Vol 20 (4) ◽  
pp. 565-576
Author(s):  
Nour Al Sawaftah ◽  
Vinod Paul ◽  
Nahid Awad ◽  
Ghaleb A. Husseini
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Cancer Drug ◽  
Drug Release Kinetics ◽  
Anti Cancer

scholarly journals In vitro modeling of hepatocellular carcinoma molecular subtypes for anti-cancer drug assessment

2018 ◽  
Vol 50 (1) ◽  
pp. e419-e419 ◽  
Author(s):  
Hadassa Hirschfield ◽  
C Billie Bian ◽  
Takaaki Higashi ◽  
Shigeki Nakagawa ◽  
Tizita Z Zeleke ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Molecular Subtypes ◽  
Cancer Drug ◽  
In Vitro Modeling ◽  
Anti Cancer

scholarly journals Influence of Progesterone-Treatment Length and eCG Administration on Appearance of Estrus Behavior, Ovulatory Success and Fertility in Sheep

Animals ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 9 ◽  
Author(s):  
Paula Martinez-Ros ◽  
Alejandro Rios-Abellan ◽  
Antonio Gonzalez-Bulnes
Keyword(s):  
Drug Release ◽  
Chorionic Gonadotrophin ◽  
Ovulation Rate ◽  
The Other ◽  
Short Term ◽  
Treatment Length ◽  
Progesterone Secretion ◽  
Progesterone Treatment ◽  
Estrus Behavior

The present study characterizes, for sheep, the occurrence and timing of the onset of estrus behavior and ovulation and the yields obtained (ovulation rate, progesterone secretion, and fertility) after Controlled Internal Drug Release (CIDR) insertion for five, six, seven, or fourteen days, with or without equine chorionic gonadotrophin (eCG) in ewes of the Segureña meat breed. All the treatments showed above 80% of females displaying estrus, but the onset of estrus was earlier and more synchronized when using eCG and, among groups with eCG, onset of estrus was earlier in the sheep treated for 14 days than in the short-term treatments (p < 0.05 for all). Administration of eCG after either short- or long-term treatments assured the occurrence of fertile ovulations in all the animals. Conversely, ovulatory success without eCG was found to be dependent on treatment length, with a high percentage of animals ovulating after five days of treatment (83.3%) and very low percentages after treatment for six or seven days (40% and 20%, respectively). Ovulation rate and progesterone secretion were similar among animals ovulating, but ovulation failures predetermined the fertility yields obtained in response to the treatments. Hence, the best results were found after treatment for 14 days plus eCG, and for 5 days without eCG (83.3 for both, p < 0.05 when compared to the other groups with different treatment lengths and with or without eCG).

scholarly journals pH-responsive polymeric micelles with core–shell–corona architectures as intracellular anti-cancer drug carriers

2013 ◽  
Vol 14 (4) ◽  
pp. 044402 ◽  
Author(s):  
Bishnu Prasad Bastakoti ◽  
Shih-Hsiang Liao ◽  
Masamichi Inoue ◽  
Shin-Ichi Yusa ◽  
Masataka Imura ◽  
...  
Keyword(s):  
Polymeric Micelles ◽  
Drug Carriers ◽  
Cancer Drug ◽  
Core Shell ◽  
Ph Responsive ◽  
Anti Cancer

For Patients with Hepatocellular Carcinoma, Perioperative Transfusion is a Co-Variate for Short-Term Morbidity and Mortality but Does not Impact Long-Term Oncologic Outcomes

2017 ◽  
Vol 152 (5) ◽  
pp. S1255-S1256
Author(s):  
Bradford Kim ◽  
Jason Denbo ◽  
Catherine Davis ◽  
Yun Shin Chun ◽  
Jean Nicolas Vauthey ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Morbidity And Mortality ◽  
Oncologic Outcomes ◽  
Short Term

99mTc-conjugated manganese-based mesoporous silica nanoparticles for SPECT, pH-responsive MRI and anti-cancer drug delivery

Nanoscale ◽  
2016 ◽  
Vol 8 (47) ◽  
pp. 19573-19580 ◽  
Author(s):  
Hongbo Gao ◽  
Xiaohang Liu ◽  
Wei Tang ◽  
Dechao Niu ◽  
Bingni Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Cancer Drug ◽  
Ph Responsive ◽  
Anti Cancer ◽  
Cancer Drug Delivery
Sign in / Sign up

Export Citation Format

Share Document