scholarly journals Self-assembly of a dual functional bioactive peptide amphiphile incorporating both matrix metalloprotease substrate and cell adhesion motifs

Soft Matter ◽  
2015 ◽  
Vol 11 (16) ◽  
pp. 3115-3124 ◽  
Author(s):  
Ashkan Dehsorkhi ◽  
Ricardo M. Gouveia ◽  
Andrew M. Smith ◽  
Ian W. Hamley ◽  
Valeria Castelletto ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Self Assembly ◽  
Bioactive Peptide ◽  
Matrix Metalloprotease ◽  
Peptide Amphiphile ◽  
Dual Functional

Self-Assembly Combining Two Bioactive Peptide-Amphiphile Molecules into Nanofibers by Electrostatic Attraction

2003 ◽  
Vol 125 (24) ◽  
pp. 7146-7147 ◽  
Author(s):  
Krista L. Niece ◽  
Jeffrey D. Hartgerink ◽  
Jack J. J. M. Donners ◽  
Samuel I. Stupp
Keyword(s):  
Self Assembly ◽  
Bioactive Peptide ◽  
Electrostatic Attraction ◽  
Peptide Amphiphile

Investigation of Au SAMs Photoclick Derivatization by PM-IRRAS

2019 ◽  
Author(s):  
Mark Workentin ◽  
François Lagugné-Labarthet ◽  
Sidney Legge
Keyword(s):  
Cell Adhesion ◽  
Self Assembly ◽  
Materials Science ◽  
Fibroblast Cell ◽  
Fine Tuning ◽  
Chemical System ◽  
Infrared Reflection ◽  
Assembled Monolayers ◽  
One Step ◽  
High Degree

In this work we present a clean one-step process for modifying headgroups of self-assembled monolayers (SAMs) on gold using photo-enabled click chemistry. A thiolated, cyclopropenone-caged strained alkyne precursor was first functionalized onto a flat gold substrate through self-assembly. Exposure of the cyclopropenone SAM to UV-A light initiated the efficient photochemical decarbonylation of the cyclopropenone moiety, revealing the strained alkyne capable of undergoing the interfacial strain-promoted alkyne-azide cycloaddition (SPAAC). Irradiated SAMs were derivatized with a series of model azides with varied hydrophobicity to demonstrate the generality of this chemical system for the modification and fine-tuning of the surface chemistry on gold substrates. SAMs were characterized at each step with polarization-modulation infrared reflection-absorption spectroscopy (PM-IRRAS) to confirm successful functionalization and reactivity. Furthermore, to showcase the compatibility of this approach with biochemical applications, cyclopropenone SAMs were irradiated and modified with azide-bearing cell adhesion peptides to promote human fibroblast cell adhesion, then imaged by live cell fluorescence microscopy. Thus, the “photoclick” methodology reported here represents an improved, versatile, catalyst-free protocol that allows for a high degree of control over the modification of material surfaces, with applicability in materials science as well as biochemistry.<br>

Tuneable Hybrid Hydrogels via Complementary Self-Assembly of a Bioactive Peptide with a Robust Polysaccharide

2021 ◽  
Author(s):  
Kate Firipis ◽  
Mitchell Boyd-Moss ◽  
Benjamin Long ◽  
Chaitali Dekiwadia ◽  
William Hoskin ◽  
...  
Keyword(s):  
Self Assembly ◽  
Bioactive Peptide ◽  
Hybrid Hydrogels

Self-Assembly and Mineralization of Peptide-Amphiphile Nanofibers

Science ◽  
2001 ◽  
Vol 294 (5547) ◽  
pp. 1684-1688 ◽  
Author(s):  
J. D. Hartgerink
Keyword(s):  
Self Assembly ◽  
Peptide Amphiphile

Molecular Simulation Study of Peptide Amphiphile Self-Assembly

2008 ◽  
Vol 112 (8) ◽  
pp. 2326-2334 ◽  
Author(s):  
Yuri S. Velichko ◽  
Samuel I. Stupp ◽  
Monica Olvera de la Cruz
Keyword(s):  
Molecular Simulation ◽  
Simulation Study ◽  
Self Assembly ◽  
Peptide Amphiphile

scholarly journals Force and time-dependent self-assembly, disruption and recovery of supramolecular peptide amphiphile nanofibers

2018 ◽  
Vol 29 (28) ◽  
pp. 285701 ◽  
Author(s):  
F Begum Dikecoglu ◽  
Ahmet E Topal ◽  
Alper D Ozkan ◽  
E Deniz Tekin ◽  
Ayse B Tekinay ◽  
...  
Keyword(s):  
Self Assembly ◽  
Time Dependent ◽  
Peptide Amphiphile

pH-Controlled Hierarchical Self-Assembly of Peptide Amphiphile

2015 ◽  
Vol 48 (8) ◽  
pp. 2647-2653 ◽  
Author(s):  
Yiren Chen ◽  
Hui Xian Gan ◽  
Yen Wah Tong
Keyword(s):  
Self Assembly ◽  
Peptide Amphiphile ◽  
Ph Controlled
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