scholarly journals Electrostatic binding of polyanions using self-assembled multivalent (SAMul) ligand displays – structure–activity effects on DNA/heparin binding

2016 ◽  
Vol 7 (7) ◽  
pp. 4653-4659 ◽  
Author(s):  
Loryn E. Fechner ◽  
Buthaina Albanyan ◽  
Vânia M. P. Vieira ◽  
Erik Laurini ◽  
Paola Posocco ◽  
...  
Keyword(s):  
Heparin Binding ◽  
Structure Activity ◽  
Electrostatic Binding ◽  
Self Assembled

DNA and heparin, both highly charged polyanions, exhibit different binding preferences towards cationic ligands in nanoscale displays.

scholarly journals Unchain My Blood: Lessons Learned from Self-Assembled Dendrimers as Nanoscale Heparin Binders

Biomolecules ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 385 ◽  
Author(s):  
Domenico Marson ◽  
Erik Laurini ◽  
Suzana Aulic ◽  
Maurizio Fermeglia ◽  
Sabrina Pricl
Keyword(s):  
Biomedical Applications ◽  
Anticoagulant Activity ◽  
Lessons Learned ◽  
Clinical Settings ◽  
Computational Results ◽  
Heparin Binding ◽  
Design Synthesis ◽  
Self Assembled ◽  
Hybrid Methodology

This review work reports a collection of coupled experimental/computational results taken from our own experience in the field of self-assembled dendrimers for heparin binding. These studies present and discuss both the potentiality played by this hybrid methodology to the design, synthesis, and development of possible protamine replacers for heparin anticoagulant activity reversal in biomedical applications, and the obstacles this field has still to overcome before these molecules can be translated into nanomedicines available in clinical settings.

Anticancer and Antiangiogenic Activity of Surfactant-Free Nanoparticles Based on Self-Assembled Polymeric Derivatives of Vitamin E: Structure–Activity Relationship

2015 ◽  
Vol 16 (5) ◽  
pp. 1566-1581 ◽  
Author(s):  
Raquel Palao-Suay ◽  
María Rosa Aguilar ◽  
Francisco J. Parra-Ruiz ◽  
Mar Fernández-Gutiérrez ◽  
Juan Parra ◽  
...  
Keyword(s):  
Vitamin E ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Antiangiogenic Activity ◽  
Structure Activity ◽  
Self Assembled ◽  
Derivatives Of

scholarly journals Morphological control of self-assembled multivalent (SAMul) heparin binding in highly competitive media

2017 ◽  
Vol 53 (47) ◽  
pp. 6335-6338 ◽  
Author(s):  
Ana C. Rodrigo ◽  
Stephen M. Bromfield ◽  
Erik Laurini ◽  
Paola Posocco ◽  
Sabrina Pricl ◽  
...  
Keyword(s):  
Self Assembly ◽  
Shape Control ◽  
Heparin Binding ◽  
Morphological Control ◽  
Self Assembled

Shape control – self-assembly of ligands into different morphologies directs their ability to bind heparin.

scholarly journals Emergence of highly-ordered hierarchical nanoscale aggregates on electrostatic binding of self-assembled multivalent (SAMul) cationic micelles with polyanionic heparin

2017 ◽  
Vol 5 (2) ◽  
pp. 341-347 ◽  
Author(s):  
Vania M. P. Vieira ◽  
Ville Liljeström ◽  
Paola Posocco ◽  
Erik Laurini ◽  
Sabrina Pricl ◽  
...  
Keyword(s):  
Cationic Micelles ◽  
Electrostatic Binding ◽  
Self Assembled ◽  
Nanoscale Aggregates

Self assembled cationic micelles form well-defined structurally ordered hierarchical nanoscale aggregates on interaction with polyanionic heparin in solution.

scholarly journals Chiral recognition at self-assembled multivalent (SAMul) nanoscale interfaces – enantioselectivity in polyanion binding

2016 ◽  
Vol 52 (69) ◽  
pp. 10540-10543 ◽  
Author(s):  
Ching W. Chan ◽  
Erik Laurini ◽  
Paola Posocco ◽  
Sabrina Pricl ◽  
David K. Smith
Keyword(s):  
Molecular Recognition ◽  
Chiral Recognition ◽  
Activity Effect ◽  
Structure Activity ◽  
Chiral Molecular Recognition ◽  
Self Assembled ◽  
Nanoscale Interfaces

We investigate structure–activity effect relationships at the nanoscale chiral molecular recognition interface between enantiomeric self-assembled multivalent (SAMul) systems and biological polyanions, heparin and DNA.

Structure-activity collective properties underlying self-assembled superstructures

Nano Today ◽  
2022 ◽  
Vol 42 ◽  
pp. 101354
Author(s):  
Cong Li ◽  
Xiaoyun Qin ◽  
Zhenghao Zhang ◽  
Yujia Lv ◽  
Shengwei Zhang ◽  
...  
Keyword(s):  
Structure Activity ◽  
Self Assembled
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