scholarly journals Application of a high-throughput enantiomeric excess optical assay involving a dynamic covalent assembly: parallel asymmetric allylation and ee sensing of homoallylic alcohols

2015 ◽  
Vol 6 (12) ◽  
pp. 6747-6753 ◽  
Author(s):  
H. H. Jo ◽  
X. Gao ◽  
L. You ◽  
E. V. Anslyn ◽  
M. J. Krische
Keyword(s):  
High Throughput ◽  
Enantiomeric Excess ◽  
Parallel Synthesis ◽  
Asymmetric Allylation ◽  
Homoallylic Alcohols ◽  
Optical Assay

Parallel synthesis and high-throughput ee screening.

One-Minute Full-Gradient HPLC/UV/ELSD/MS Analysis to Support High-Throughput Parallel Synthesis

2004 ◽  
Vol 6 (5) ◽  
pp. 796-804 ◽  
Author(s):  
James N. Kyranos ◽  
Heewon Lee ◽  
Wolfgang K. Goetzinger ◽  
Lily Y. T. Li
Keyword(s):  
High Throughput ◽  
Parallel Synthesis ◽  
Ms Analysis ◽  
Gradient Hplc

High-Throughput Solid-Phase Parallel Synthesis of Peptides in 96-Well Format

ChemInform ◽  
2005 ◽  
Vol 36 (37) ◽  
Author(s):  
D. Winkler ◽  
G. Morbach ◽  
C. Hessenius ◽  
M. Ritzke ◽  
J. Schmidt ◽  
...  
Keyword(s):  
High Throughput ◽  
Solid Phase ◽  
Parallel Synthesis

scholarly journals Catalytic Asymmetric Allylation of Aldehydes with Alkenes Mediated by Organophotoredox and Chiral Chromium Hybrid Catalysis

2018 ◽  
Author(s):  
Harunobu Mitsunuma ◽  
Shun Tanabe ◽  
Hiromu Fuse ◽  
Kei Ohkubo ◽  
Motomu Kanai
Keyword(s):  
Visible Light ◽  
Hybrid System ◽  
Visible Light Irradiation ◽  
Room Temperature ◽  
Functional Group ◽  
Light Irradiation ◽  
Asymmetric Allylation ◽  
Complex Catalyst ◽  
Homoallylic Alcohols ◽  
Catalytic Asymmetric

A hybrid system accomplishing cooperativity between an organophotoredox acridinium catalyst and a chiral chromium<br>complex catalyst was developed, enabling the unprecedented exploitation of unactivated hydrocarbon alkenes as precursors to chiral allylchromium nucleophiles for the asymmetric allylation of aldehydes. The reaction proceeded under visible light irradiation at room temperature and with high functional group tolerance, affording the corresponding homoallylic alcohols with up to >20/1 diastereomeric ratio and 99% ee. The addition of Mg(ClO4)2 elicited profound enhancement of both reactivity and enantioselectivity.

scholarly journals A Set of Platforms with Combinatorial and High-Throughput Technique for Gas Sensing, from Material to Device and to System

Micromachines ◽  
2018 ◽  
Vol 9 (11) ◽  
pp. 606 ◽  
Author(s):  
Zhenghao Mao ◽  
Jianchao Wang ◽  
Youjin Gong ◽  
Heng Yang ◽  
Shunping Zhang
Keyword(s):  
Gas Sensor ◽  
High Throughput ◽  
System Integration ◽  
Sensor Array ◽  
Gas Sensing ◽  
Parallel Synthesis ◽  
Testing Platform ◽  
Long Time ◽  
Sensitivity And Selectivity ◽  
Array Optimization

In a new E-nose development, the sensor array needs to be optimized to have enough sensitivity and selectivity for gas/odor classification in the application. The development process includes the preparation of gas sensitive materials, gas sensor fabrication, array optimization, sensor array package and E-nose system integration, which would take a long time to complete. A set of platforms including a gas sensing film parallel synthesis platform, high-throughput gas sensing unmanned testing platform and a handheld wireless E-nose system were presented in this paper to improve the efficiency of a new E-nose development. Inkjet printing was used to parallel synthesize sensor libraries (400 sensors can be prepared each time). For gas sensor selection and array optimization, a high-throughput unmanned testing platform was designed and fabricated for gas sensing measurements of more than 1000 materials synchronously. The structures of a handheld wireless E-nose system with low power were presented in detail. Using the proposed hardware platforms, a new E-nose development might only take one week.

High Throughput Solid Phase Parallel Synthesis of Macrocyclic Peptidomimetics

2009 ◽  
pp. 15-16 ◽  
Author(s):  
E. Marsault ◽  
H. R. Hoveyda ◽  
M. L. Peterson ◽  
R. Gagnon ◽  
M. Vézina ◽  
...  
Keyword(s):  
High Throughput ◽  
Solid Phase ◽  
Parallel Synthesis
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