scholarly journals Mechanisms and energetics of free radical initiated disulfide bond cleavage in model peptides and insulin by mass spectrometry

2015 ◽  
Vol 6 (8) ◽  
pp. 4550-4560 ◽  
Author(s):  
Chang Ho Sohn ◽  
Jinshan Gao ◽  
Daniel A. Thomas ◽  
Tae-Young Kim ◽  
William A. Goddard III ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Free Radical ◽  
Disulfide Bond ◽  
Bond Cleavage ◽  
Radical Substitution ◽  
Model Peptides

Direct radical substitution at sulfur initiates disulfide bond cleavage by hydrogen-deficient radicals in peptides and proteins.

Disulfide bond cleavage in TEMPO-free radical initiated peptide sequencing mass spectrometry

2011 ◽  
Vol 46 (8) ◽  
pp. 830-839 ◽  
Author(s):  
Minhee Lee ◽  
Younjin Lee ◽  
Minhyuk Kang ◽  
Hyeyeon Park ◽  
Yeonmi Seong ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Free Radical ◽  
Disulfide Bond ◽  
Bond Cleavage ◽  
Peptide Sequencing

Mass spectrometry study of PRL-3 phosphatase inactivation by disulfide bond formation and cysteine into glycine conversion

2009 ◽  
Vol 23 (17) ◽  
pp. 2733-2740 ◽  
Author(s):  
Laura Orsatti ◽  
Federica Innocenti ◽  
Paola Lo Surdo ◽  
Fabio Talamo ◽  
Gaetano Barbato
Keyword(s):  
Mass Spectrometry ◽  
Disulfide Bond ◽  
Bond Formation ◽  
Disulfide Bond Formation ◽  
Mass Spectrometry Study

Alkali-modified soy proteins: Effect of salts and disulfide bond cleavage on adhesion and viscosity

1996 ◽  
Vol 73 (8) ◽  
pp. 1063-1066 ◽  
Author(s):  
U. Kalapathy ◽  
N. S. Hettiarachchy ◽  
D. Myers ◽  
K. C. Rhee
Keyword(s):  
Disulfide Bond ◽  
Bond Cleavage ◽  
Soy Proteins

Free Radical Substitution Reactions of Sulfur Monochloride. A Limited Synthesis of Mercaptans

1973 ◽  
Vol 51 (20) ◽  
pp. 3366-3372 ◽  
Author(s):  
Dennis D. Tanner ◽  
Brian G. Brownlee
Keyword(s):  
Free Radical ◽  
Lithium Aluminum Hydride ◽  
Elemental Sulfur ◽  
Aluminum Hydride ◽  
Lithium Aluminum ◽  
Substitution Reactions ◽  
Sulfur Monochloride ◽  
Hydride Reduction ◽  
Abstraction Reaction ◽  
Radical Substitution

The photolysis of sulfur monochloride with a series of saturated aliphatic hydrocarbons yielded alkyl chlorides, di- and polysulfides, hydrogen chloride, and elemental sulfur. The free radical substitution reactions leading to the production of alkyl chloride and the di- and polysulfides were shown to proceed via a chlorine atom abstraction reaction. The major products, the di- and polysulfides could be transformed quantitatively, by lithium aluminum hydride reduction into their corresponding mercaptans. The reaction describes a simple free radical route to the synthesis of a variety of alkyl mercaptans.

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