scholarly journals Direct in vivo imaging of ferrous iron dyshomeostasis in ageing Caenorhabditis elegans

2015 ◽  
Vol 6 (5) ◽  
pp. 2952-2962 ◽  
Author(s):  
Simon A. James ◽  
Blaine R. Roberts ◽  
Dominic J. Hare ◽  
Martin D. de Jonge ◽  
Ian E. Birchall ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Fluorescence Imaging ◽  
In Vivo Imaging ◽  
Ferrous Iron ◽  
Iron Homeostasis ◽  
X Ray

Synchrotron-based X-ray fluorescence imaging and metalloproteomics reveals a loss of iron homeostasis in ageing Caenorhabditis elegans.

scholarly journals φXANES: In vivo imaging of metal-protein coordination environments

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Simon A. James ◽  
Dominic J. Hare ◽  
Nicole L. Jenkins ◽  
Martin D. de Jonge ◽  
Ashley I. Bush ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Fluorescence Imaging ◽  
Fluorescence Detection ◽  
In Vivo Imaging ◽  
Spectroscopy Method ◽  
Edge Structure ◽  
X Ray ◽  
Chemical Damage ◽  
X Ray Absorption

Abstract We have developed an X-ray absorption near edge structure spectroscopy method using fluorescence detection for visualizing in vivo coordination environments of metals in biological specimens. This approach, which we term fluorescence imaging XANES (φXANES), allows us to spatially depict metal-protein associations in a native, hydrated state whilst avoiding intrinsic chemical damage from radiation. This method was validated using iron-challenged Caenorhabditis elegans to observe marked alterations in redox environment.

Stable Twisted Conformation Aza-BODIPY NIR-II Fluorescent Nanoparticles with Ultra-large Stokes Shift for Imaging-Guided Phototherapy

2022 ◽  
Author(s):  
Youliang Tian ◽  
Huiting Zhou ◽  
Quan Cheng ◽  
Huiping Dang ◽  
Hongyun Qian ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Stokes Shift ◽  
Great Promise ◽  
Deep Penetration ◽  
Fluorescent Nanoparticles ◽  
Spatiotemporal Resolution ◽  
Large Stokes Shift

Fluorescence imaging in the second near-infrared window (NIR-II, 1000–1700 nm) holds great promise for in vivo imaging and imaging-guided phototherapy with deep penetration and high spatiotemporal resolution. It is very...

scholarly journals Real-time in vivo imaging of regional lung function in a mouse model of cystic fibrosis on a laboratory X-ray source

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Rhiannon P. Murrie ◽  
Freda Werdiger ◽  
Martin Donnelley ◽  
Yu-wei Lin ◽  
Richard P. Carnibella ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Mouse Model ◽  
Real Time ◽  
In Vivo Imaging ◽  
X Ray ◽  
Regional Lung Function ◽  
Regional Lung

Microfluidics for in vivo imaging of neuronal and behavioral activity in Caenorhabditis elegans

2007 ◽  
Vol 4 (9) ◽  
pp. 727-731 ◽  
Author(s):  
Nikos Chronis ◽  
Manuel Zimmer ◽  
Cornelia I Bargmann
Keyword(s):  
Caenorhabditis Elegans ◽  
In Vivo Imaging ◽  
Behavioral Activity

scholarly journals X-ray-Fluorescence Imaging for In Vivo Detection of Gold-Nanoparticle-Labeled Immune Cells: A GEANT4 Based Feasibility Study

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5759
Author(s):  
Arthur Ungerer ◽  
Theresa Staufer ◽  
Oliver Schmutzler ◽  
Christian Körnig ◽  
Kai Rothkamm ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Cell Tracking ◽  
Immune Cell ◽  
High Sensitivity ◽  
Diagnostic Tools ◽  
Monte Carlo Simulation Study ◽  
X Ray ◽  
In Vivo Detection ◽  
Technological Developments

The growing field of cellular therapies in regenerative medicine and oncology calls for more refined diagnostic tools that are able to investigate and monitor the function and success of said therapies. X-ray Fluorescence Imaging (XFI) can be applied for molecular imaging with nanoparticles, such as gold nanoparticles (GNPs), which can be used in immune cell tracking. We present a Monte Carlo simulation study on the sensitivity of detection and associated radiation dose estimations in an idealized setup of XFI in human-sized objects. Our findings demonstrate the practicability of XFI in human-sized objects, as immune cell tracking with a minimum detection limit of 4.4 × 105 cells or 0.86 μg gold in a cubic volume of 1.78 mm3 can be achieved. Therefore, our results show that the current technological developments form a good basis for high sensitivity XFI.

scholarly journals Rational design of a NIR-II fluorescent nano-system with maximized fluorescence performance and applications

2021 ◽  
Author(s):  
Haoli Yu ◽  
Yuesong Wang ◽  
Yan Chen ◽  
Min Ji
Keyword(s):  
Fluorescence Imaging ◽  
In Vivo Imaging ◽  
Rational Design ◽  
Near Infrared ◽  
Nir Fluorescence

Purpose: Near-infrared (NIR) fluorescence imaging (FI) become a research hotspot in the field of in vivo imaging. Here, we intend to synthesize a NIR-II fluorescence nano-system with an excellent fluorescence...

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