Highly efficient and scalable chemoenzymatic syntheses of (R)- and (S)-lactaldehydes

2016 ◽  
Vol 1 (2) ◽  
pp. 156-160 ◽  
Author(s):  
M. A. K. Vogel ◽  
H. Burger ◽  
N. Schläger ◽  
R. Meier ◽  
B. Schönenberger ◽  
...  
Keyword(s):  
Protecting Group ◽  
Highly Efficient ◽  
Excellent Yield ◽  
Key Steps ◽  
Yield And Purity

Biocatalytic asymmetric reductions have been key steps in the synthesis of 1,1-dimethoxy-2-propanone, catalyzed by suitable ketoreductases to (S)- and (R)-1,1-dimethoxy-2-propanol, obtained in ≥99.9% ee and excellent yield. Removal of the protecting group gave the (S)- and (R)-lactaldehydes in excellent yield and purity.

Sulfated polyborate: a new and eco-friendly catalyst for one-pot multi-component synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via Biginelli reaction

2016 ◽  
Vol 40 (12) ◽  
pp. 10412-10417 ◽  
Author(s):  
Chetan K. Khatri ◽  
Deelip S. Rekunge ◽  
Ganesh U. Chaturbhuj
Keyword(s):  
Biginelli Reaction ◽  
Solvent Free ◽  
Synthetic Methodology ◽  
One Pot ◽  
Free Condition ◽  
Sulfated Polyborate ◽  
Highly Efficient ◽  
Excellent Yield ◽  
Solvent Free Condition

A highly efficient and improved synthetic methodology for the preparation of 3,4-dihydropyrimidin-2(1H)-one derivatives in good to excellent yield via Biginelli reaction of β-ketoesters/β-diketone, urea/thiourea and various aldehydes using new, efficient and recyclable sulfated polyborate catalyst under the solvent-free condition is reported.

A Highly Efficient Azide-Based Protecting Group for Amines and Alcohols.

ChemInform ◽  
2007 ◽  
Vol 38 (39) ◽  
Author(s):  
Srinivasu Pothukanuri ◽  
Nicolas Winssinger
Keyword(s):  
Protecting Group ◽  
Highly Efficient

A Practical Gram-Scale Synthesis of Acrylohydroxamic Acid

Synthesis ◽  
2017 ◽  
Vol 49 (24) ◽  
pp. 5335-5338
Author(s):  
Bruce Hamper ◽  
Brendan Sullivan ◽  
Nigam Rath ◽  
Christopher Spilling
Keyword(s):  
Acrylic Acid ◽  
Polymeric Materials ◽  
Protecting Group ◽  
Acid Cleavage ◽  
Key Steps

Acrylohydroxamic acid, which is a useful monomer for the preparation of polymeric materials, has been prepared in a straightforward, two-step synthesis from readily available starting materials. The key steps are coupling of acrylic acid with O-tetrahydropyranylhydroxyl amine to provide protection of the hydroxylamine functionality, followed by acid cleavage of the protecting group.

scholarly journals Air-stable, recyclable, and time-efficient diphenylphosphinite cellulose-supported palladium nanoparticles as a catalyst for Suzuki–Miyaura reactions

2011 ◽  
Vol 7 ◽  
pp. 378-385 ◽  
Author(s):  
Qingwei Du ◽  
Yiqun Li
Keyword(s):  
Heterogeneous Catalyst ◽  
Palladium Nanoparticles ◽  
Palladium Complex ◽  
Complex Cell ◽  
Reaction Conditions ◽  
Highly Efficient ◽  
Excellent Yield ◽  
Simple Filtration ◽  
Supported Palladium ◽  
Efficient Heterogeneous Catalyst

A diphenylphosphinite cellulose palladium complex (Cell–OPPh2–Pd0) was found to be a highly efficient heterogeneous catalyst for the Suzuki–Miyaura reaction. The products were obtained in good to excellent yield under mild reaction conditions. Moreover, the catalyst could be easily recovered by simple filtration and reused for at least 6 cycles without losing its activity.

Protecting-Group-Free Total Synthesis of Anticancer (±)-Melotenine A

Synthesis ◽  
2021 ◽  
Author(s):  
Adisak Thanetchaiyakup ◽  
Hassayaporn Rattanarat ◽  
Sudaporn Aree ◽  
Tanwawan Duangthongyou ◽  
Tanin Nanok ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Human Cancer ◽  
Alder Reaction ◽  
Diels Alder ◽  
Protecting Groups ◽  
Protecting Group ◽  
Ring Closing Metathesis ◽  
Human Cancer Cell Lines ◽  
Diels Alder Reaction ◽  
Key Steps

Melotenine A, isolated from Melodinus tenuicaudatus, possesses significant anticancer activity against several human cancer cell lines. The synthesis of (±)-melotenine A was achieved without the use of any protecting groups in 11 steps with an overall yield of 7%. The key steps of our strategy were the Diels–Alder reaction to construct the tetracyclic framework and ring-closing metathesis to form the seven-membered ring of (±)-melotenine A.

scholarly journals Scalable Route to Chiral Phosphoramidites

2016 ◽  
Vol 8 (2) ◽  
pp. 64
Author(s):  
Sergiy G. Krasutsky ◽  
Sheila H. Jacobo
Keyword(s):  
General Structure ◽  
Conjugate Addition ◽  
Highly Efficient ◽  
Excellent Yield ◽  
Convenient Route ◽  
Pdf Format

The chiral copper-catalyzed conjugate addition is a well-developed methodology to create asymmetric C-C bonds. Many efforts have been dedicated to design efficient systems and identifying highly efficient ligands. Among the most proficient ligands, the ones possessing a bis-phenol or a bis-naphthol moiety are the most prominent. Herein we describe a scalable convenient route that can afford phosphoramidites in excellent yield.<br />Please find "Figure 1. General structure and application of phosphoramidites" in PDF format.

scholarly journals Synthesis of Plakortolides E and I Enabled by Base Metal Catalysis

2021 ◽  
Author(s):  
Stefan Leisering ◽  
Alexandros Mavroskoufis ◽  
Patrick Voßnacker ◽  
Reinhold Zimmer ◽  
Mathias Christmann
Keyword(s):  
Natural Products ◽  
Transition Metals ◽  
Base Metal ◽  
Protecting Group ◽  
Efficient Synthesis ◽  
One Pot ◽  
Metal Catalysis ◽  
Bond Forming ◽  
Earth Abundant ◽  
Key Steps

A protecting-group-free synthesis of two endoperoxide natural products, plakortolide E and plakortolide I, is reported. Key-steps feature the use of earth-abundant transition metals, consisting of a vanadium-mediated epoxidation, an iron-catalyzed allylic substitution, and a cobalt-induced endoperoxide formation. Our approach combines redox-economy, chemoselective bond-forming reactions, and telescoping into one-pot operations to forge an overall efficient synthesis.

scholarly journals Synthesis of Plakortolides E and I Enabled by Base Metal Catalysis

2021 ◽  
Author(s):  
Stefan Leisering ◽  
Alexandros Mavroskoufis ◽  
Patrick Voßnacker ◽  
Reinhold Zimmer ◽  
Mathias Christmann
Keyword(s):  
Natural Products ◽  
Transition Metals ◽  
Base Metal ◽  
Protecting Group ◽  
Efficient Synthesis ◽  
One Pot ◽  
Metal Catalysis ◽  
Bond Forming ◽  
Earth Abundant ◽  
Key Steps

A protecting-group-free synthesis of two endoperoxide natural products, plakortolide E and plakortolide I, is reported. Key-steps feature the use of earth-abundant transition metals, consisting of a vanadium-mediated epoxidation, an iron-catalyzed allylic substitution, and a cobalt-induced endoperoxide formation. Our approach combines redox-economy, chemoselective bond-forming reactions, and telescoping into one-pot operations to forge an overall efficient synthesis.

A Highly Efficient Azide-Based Protecting Group for Amines and Alcohols

2007 ◽  
Vol 9 (11) ◽  
pp. 2223-2225 ◽  
Author(s):  
Srinivasu Pothukanuri ◽  
Nicolas Winssinger
Keyword(s):  
Protecting Group ◽  
Highly Efficient
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