Effectiveness of wound healing using the novel collagen dermal substitute INSUREGRAF®

RSC Advances ◽  
2016 ◽  
Vol 6 (64) ◽  
pp. 59692-59701 ◽  
Author(s):  
Hyeon Yoon ◽  
Hyeong Tae Yang ◽  
Haejun Yim ◽  
Dohern Kym ◽  
Jun Hur ◽  
...  
Keyword(s):  
Wound Healing ◽  
Pore Structure ◽  
Skin Regeneration ◽  
Dermal Substitute ◽  
The Novel ◽  
Cell Penetration

The pore structure of INSUREGRAF® built up from parallel collagen layers connected by single fivers and sizes are very uniform. Therefore, this is more suitable with respect to cell penetration, distribution, and acceleration of skin regeneration.

scholarly journals Glibenclamide Nanocrystal-Loaded Bioactive Polymeric Scaffolds for Skin Regeneration: In Vitro Characterization and Preclinical Evaluation

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1469
Author(s):  
Julie R. Youssef ◽  
Nabila A. Boraie ◽  
Heba F. Ibrahim ◽  
Fatma A. Ismail ◽  
Riham M. El-Moslemany
Keyword(s):  
Wound Healing ◽  
Skin Regeneration ◽  
In Vivo Studies ◽  
Dermal Substitute ◽  
Full Thickness ◽  
In Vitro Characterization ◽  
Polymeric Scaffolds ◽  
Chitosan Composite

Skin restoration following full-thickness injury poses significant clinical challenges including inflammation and scarring. Medicated scaffolds formulated from natural bioactive polymers present an attractive platform for promoting wound healing. Glibenclamide was formulated in collagen/chitosan composite scaffolds to fulfill this aim. Glibenclamide was forged into nanocrystals with optimized colloidal properties (particle size of 352.2 nm, and polydispersity index of 0.29) using Kolliphor as a stabilizer to allow loading into the hydrophilic polymeric matrix. Scaffolds were prepared by the freeze drying method using different total polymer contents (3–6%) and collagen/chitosan ratios (0.25–2). A total polymer content of 3% at a collagen/chitosan ratio of 2:1 (SCGL3-2) was selected based on the results of in vitro characterization including the swelling index (1095.21), porosity (94.08%), mechanical strength, rate of degradation and in vitro drug release. SCGL3-2 was shown to be hemocompatible based on the results of protein binding, blood clotting and percentage hemolysis assays. In vitro cell culture studies on HSF cells demonstrated the biocompatibility of nanocrystals and SCGL3-2. In vivo studies on a rat model of a full-thickness wound presented rapid closure with enhanced histological and immunohistochemical parameters, revealing the success of the scaffold in reducing inflammation and promoting wound healing without scar formation. Hence, SCGL3-2 could be considered a potential dermal substitute for skin regeneration.

A clinical trial with a novel collagen dermal substitute for wound healing in burn patients

2020 ◽  
Vol 8 (3) ◽  
pp. 823-829 ◽  
Author(s):  
Dogeon Yoon ◽  
Yoon Soo Cho ◽  
So Young Joo ◽  
Cheong Hoon Seo ◽  
Yong Suk Cho
Keyword(s):  
Clinical Trial ◽  
Wound Healing ◽  
Biomechanical Properties ◽  
Skin Regeneration ◽  
Dermal Substitute ◽  
Burn Patients ◽  
Medical Field ◽  
Commercial Products ◽  
Burn Wounds

Biomechanical properties of new dermal replacement were very similar than commercial products. Also this replacement can be used for skin regeneration for burn wounds. Therefore, we suggest that new dermal replacement can be used in the medical field.

Wound Healing Microenvironmental Cues: From Tissue Analogs to Skin Regeneration

2013 ◽  
Vol 2 (2) ◽  
pp. 145-153 ◽  
Author(s):  
Mariana Cerqueira ◽  
Rui Reis ◽  
Alexendra Marques
Keyword(s):  
Wound Healing ◽  
Skin Regeneration

scholarly journals Engineering Bioactive Self-Healing Antibacterial Exosomes Hydrogel for Promoting Chronic Diabetic Wound Healing and Complete Skin Regeneration: Erratum

Theranostics ◽  
2021 ◽  
Vol 11 (20) ◽  
pp. 10174-10175
Author(s):  
Chenggui Wang ◽  
Min Wang ◽  
Tianzhen Xu ◽  
Xingxing Zhang ◽  
Cai Lin ◽  
...  
Keyword(s):  
Wound Healing ◽  
Skin Regeneration ◽  
Self Healing ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

The Novel Role of Kallistatin in Wound Healing and Diabetes

2020 ◽  
Vol 331 ◽  
pp. 10
Author(s):  
Dimitrios Karamichos ◽  
Wentao Liang ◽  
Jian-Xing Ma
Keyword(s):  
Wound Healing ◽  
The Novel

Integrin-binding pro-survival peptide engineered silk fibroin nanosheets for diabetic wound healing and skin regeneration

2020 ◽  
Vol 398 ◽  
pp. 125617
Author(s):  
Huishang Yang ◽  
Chen Lai ◽  
Chengkai Xuan ◽  
Muyuan Chai ◽  
Xuemin Liu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silk Fibroin ◽  
Skin Regeneration ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

scholarly journals A gelatin/collagen/polycaprolactone scaffold for skin regeneration

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e6358 ◽  
Author(s):  
Lin-Gwei Wei ◽  
Hsin-I Chang ◽  
Yiwei Wang ◽  
Shan-hui Hsu ◽  
Lien-Guo Dai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Dermal Fibroblasts ◽  
Skin Regeneration ◽  
Collagen Content ◽  
Wound Dressings ◽  
Skin Substitute ◽  
Epidermal Keratinocytes ◽  
Adipose Derived Stem Cells

Background A tissue-engineered skin substitute, based on gelatin (“G”), collagen (“C”), and poly(ε-caprolactone) (PCL; “P”), was developed. Method G/C/P biocomposites were fabricated by impregnation of lyophilized gelatin/collagen (GC) mats with PCL solutions, followed by solvent evaporation. Two different GC:PCL ratios (1:8 and 1:20) were used. Results Differential scanning calorimetry revealed that all G/C/P biocomposites had characteristic melting point of PCL at around 60 °C. Scanning electron microscopy showed that all biocomposites had similar fibrous structures. Good cytocompatibility was present in all G/C/P biocomposites when incubated with primary human epidermal keratinocytes (PHEK), human dermal fibroblasts (PHDF) and human adipose-derived stem cells (ASCs) in vitro. All G/C/P biocomposites exhibited similar cell growth and mechanical characteristics in comparison with C/P biocomposites. G/C/P biocomposites with a lower collagen content showed better cell proliferation than those with a higher collagen content in vitro. Due to reasonable mechanical strength and biocompatibility in vitro, G/C/P with a lower content of collagen and a higher content of PCL (GCLPH) was selected for animal wound healing studies. According to our data, a significant promotion in wound healing and skin regeneration could be observed in GCLPH seeded with adipose-derived stem cells by Gomori’s trichrome staining. Conclusion This study may provide an effective and low-cost wound dressings to assist skin regeneration for clinical use.

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