Differential interactions of imatinib mesylate with the membrane skeletal protein spectrin and hemoglobin

Debashree Das; Ushasi Pramanik; Malay Patra; Mousumi Banerjee; Abhijit Chakrabarti

doi:10.1039/c5ra27276a

Differential interactions of imatinib mesylate with the membrane skeletal protein spectrin and hemoglobin

RSC Advances ◽

10.1039/c5ra27276a ◽

2016 ◽

Vol 6 (60) ◽

pp. 55203-55210 ◽

Cited By ~ 3

Author(s):

Debashree Das ◽

Ushasi Pramanik ◽

Malay Patra ◽

Mousumi Banerjee ◽

Abhijit Chakrabarti

Keyword(s):

Imatinib Mesylate ◽

Dissociation Constants ◽

Skeletal Protein

The anti-leukaemia drug imatinib has been shown to bind to spectrin, and to hemoglobin in its oxy-form with binding dissociation constants of 48 μM and 63 μM at 25 °C respectively.

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Implications of imatinib mesylate for hematopoietic stem cell transplantation

Seminars in Hematology ◽

10.1053/shem.2001.27081 ◽

2001 ◽

Vol 38 (3, Suppl 8) ◽

pp. 28-34 ◽

Cited By ~ 1

Author(s):

John Goldman

Keyword(s):

Stem Cell ◽

Hematopoietic Stem Cell Transplantation ◽

Stem Cell Transplantation ◽

Imatinib Mesylate ◽

Cell Transplantation ◽

Hematopoietic Stem Cell ◽

Hematopoietic Stem

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Initial experiences utilizing perfusion CT in the follow-up of patients with gastrointestinal stromal tumors under imatinib mesylate treatment

RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren ◽

10.1055/s-0028-1085909 ◽

2008 ◽

Vol 180 (09) ◽

Author(s):

F Berger ◽

M Hittinger ◽

M Schlemmer ◽

T Saam ◽

K Nikolaou ◽

...

Keyword(s):

Imatinib Mesylate ◽

Gastrointestinal Stromal Tumors ◽

Perfusion Ct ◽

Stromal Tumors

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Factors Influencing the Separation of Glu-Plasminogen Affinity Forms I and II by Affinity Chromatography

Thrombosis and Haemostasis ◽

10.1055/s-0038-1661211 ◽

1984 ◽

Vol 52 (03) ◽

pp. 347-349 ◽

Cited By ~ 6

Author(s):

Daan W Traas ◽

Bep Hoegee-de Nobel ◽

Willem Nieuwenhuizen

Keyword(s):

Affinity Chromatography ◽

Dissociation Constants ◽

Ionic Composition ◽

Chloride Ions ◽

Factors Influencing ◽

Two Factors ◽

Human Plasminogen

SummaryNative human plasminogen, the proenzyme of plasmin (E. C. 3.4.21.7) occurs in blood in two well defined forms, affinity forms I and II. In this paper, the feasibility of separating these forms of human native plasminogen by affinity chromatography, is shown to be dependent on two factors: 1) the ionic composition of the buffer containing the displacing agent: buffers of varying contents of sodium, Tris, phosphate and chloride ions were compared, and 2) the type of adsorbent. Two adsorbents were compared: Sepharose-lysine and Sepharose-bisoxirane-lysine. Only in the phosphate containing buffers, irrespective of the type of adsorbent, the affinity forms can be separated. The influence of the adsorbent can be accounted for by a large difference in dissociation constants of the complex between plasminogen and the immobilized lysine.

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