Poly(3-hydroxybutyrate-co-valerate)/poly(3-thiophene ethyl acetate) blends as a electroactive biomaterial substrate for tissue engineering application

RSC Advances ◽  
2016 ◽  
Vol 6 (30) ◽  
pp. 25330-25338 ◽  
Author(s):  
M. S. Recco ◽  
A. C. Floriano ◽  
D. B. Tada ◽  
A. P. Lemes ◽  
R. Lang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cell Proliferation ◽  
Ethyl Acetate ◽  
Mammalian Cell ◽  
Engineering Application ◽  
Chemical Properties ◽  
Tissue Engineering Application ◽  
Good Adhesion ◽  
Physical Chemical ◽  
Low Cytotoxicity

Polyblend films based on poly(3-hydroxybutirate-co-valerate) and poly(3-thiophene ethyl acetate) – PHBV/PTAcEt showed low cytotoxicity, good adhesion and mammalian cell proliferation. The physical–chemical properties were explored.

scholarly journals Crosslinking Collagen Constructs: Achieving Cellular Selectivity Through Modifications of Physical and Chemical Properties

2020 ◽  
Vol 10 (19) ◽  
pp. 6911
Author(s):  
Malavika Nair ◽  
Serena M. Best ◽  
Ruth E. Cameron
Keyword(s):  
Tissue Engineering ◽  
Cell Viability ◽  
Biomedical Applications ◽  
Engineering Application ◽  
Chemical Properties ◽  
Tissue Engineering Application ◽  
Physical And Chemical Properties ◽  
Crosslinking Process ◽  
Physical And Chemical ◽  
And Chemical Properties

Collagen-based constructs have emerged in recent years as ideal candidates for tissue engineering implants. For many biomedical applications, collagen is crosslinked in order to improve the strength, stiffness and stability of the construct. However, the crosslinking process may also result in unintended changes to cell viability, adhesion or proliferation on the treated structures. This review provides a brief overview of some of both the most commonly used and novel crosslinkers used with collagen, and suggests a framework by which crosslinking methods can be compared and selected for a given tissue engineering application.

scholarly journals Hybrid Methacrylated Gelatin and Hyaluronic Acid Hydrogel Scaffolds. Preparation and Systematic Characterization for Prospective Tissue Engineering Applications

2021 ◽  
Vol 22 (13) ◽  
pp. 6758
Author(s):  
B. Velasco-Rodriguez ◽  
T. Diaz-Vidal ◽  
L. C. Rosales-Rivera ◽  
C. A. García-González ◽  
C. Alvarez-Lorenzo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Engineering Application ◽  
Chemical Properties ◽  
Tissue Engineering Application ◽  
Hydrogel Scaffolds ◽  
Hybrid Hydrogels ◽  
Physico Chemical ◽  
Scaffold Structure ◽  
The Relationship

Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively. However, despite previous studies conducted so far, the relationship between composition and scaffold structure and physico-chemical properties has not been completely and systematically established. In this work, pure and hybrid hydrogels of methacroyl-modified HA (HAMA) and Gel (GelMA) were prepared by UV photopolymerization and an extensive characterization was done to elucidate such correlations. Methacrylation degrees of ca. 40% and 11% for GelMA and HAMA, respectively, were obtained, which allows to improve the hydrogels’ mechanical properties. Hybrid GelMA/HAMA hydrogels were stiffer, with elastic modulus up to ca. 30 kPa, and porous (up to 91%) compared with pure GelMA ones at similar GelMA concentrations thanks to the interaction between HAMA and GelMA chains in the polymeric matrix. The progressive presence of HAMA gave rise to scaffolds with more disorganized, stiffer, and less porous structures owing to the net increase of mass in the hydrogel compositions. HAMA also made hybrid hydrogels more swellable and resistant to collagenase biodegradation. Hence, the suitable choice of polymeric composition allows to regulate the hydrogels´ physical properties to look for the most optimal characteristics required for the intended tissue engineering application.

scholarly journals Physico-Chemical Properties and Biocompatibility of Thermosensitive Chitosan Lactate and Chitosan Chloride Hydrogels Developed for Tissue Engineering Application

2021 ◽  
Vol 12 (2) ◽  
pp. 37
Author(s):  
Katarzyna Pieklarz ◽  
Grzegorz Galita ◽  
Michał Tylman ◽  
Waldemar Maniukiewicz ◽  
Ewa Kucharska ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Engineering Application ◽  
Chemical Properties ◽  
Disodium Salt ◽  
Initial Structure ◽  
Tissue Engineering Application ◽  
Glycerol Phosphate ◽  
Structural Investigations ◽  
Chitosan Hydrogels ◽  
Chitosan Lactate

Recently, the modification of the initial structure of biopolymers, mainly chitosan, has been gaining importance with a view to obtain functional forms with increased practicality and specific properties enabling their use in tissue engineering. Therefore, in this article, the properties (structural and biological) of thermosensitive hydrogels obtained from chitosan lactate/chloride and two types of crosslinking agents (β-glycerol phosphate disodium salt pentahydrate and uridine 5′-monophosphate disodium salt) are discussed. The aim of the research is to identify changes in the structure of the biomaterials during conditioning in water. Structural investigations were carried out by FTIR spectroscopy. The crystallinity of gels was determined by X-ray diffraction analysis. The biocompatibility (evaluation of cytotoxicity and genotoxicity) of chitosan hydrogels was investigated by contact with human colon adenocarcinoma cell line for 48 h. The cytotoxicity was verified based on the colorimetric resazurin assay, and the genotoxicity was checked by the comet assay (percentage of DNA in the comet tail). The conducted research showed that the analyzed types of chitosan hydrogels are non-cytotoxic and non-genotoxic materials. The good biocompatibility of chitosan hydrogels surfaces makes them interesting scaffolds with clinical potential in tissue regeneration engineering.

Fabrication of magnetite nanoparticle doped reduced graphene oxide grafted polyhydroxyalkanoate nanocomposites for tissue engineering application

RSC Advances ◽  
2016 ◽  
Vol 6 (52) ◽  
pp. 46116-46133 ◽  
Author(s):  
Nilkamal Pramanik ◽  
Jibankrishna De ◽  
Ranjan Kumar Basu ◽  
Tanmoy Rath ◽  
Patit Paban Kundu
Keyword(s):  
Tissue Engineering ◽  
Cell Proliferation ◽  
Tissue Regeneration ◽  
Engineering Application ◽  
Magnetic Nanocomposites ◽  
Tissue Engineering Application ◽  
Magnetite Nanoparticle ◽  
Reduced Graphene ◽  
Regeneration Phase ◽  
Cell Construction

In tissue engineering, the magnetic nanocomposites are more attractive due to some superior properties that promote in the monitoring of cell proliferation, differentiation and activation of cell construction in tissue regeneration phase.

Coating of Laponite on PLA Nanofibrous for Bone Tissue Engineering Application

2021 ◽  
Vol 29 (3) ◽  
pp. 191-198
Author(s):  
Zahra Orafa ◽  
Shiva Irani ◽  
Ali Zamanian ◽  
Hadi Bakhshi ◽  
Habib Nikukar ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Application ◽  
Tissue Engineering Application ◽  
Bone Tissue Engineering Application

Electrospun nano-bio membrane for bone tissue engineering application- a new approach

2020 ◽  
Vol 249 ◽  
pp. 123010 ◽  
Author(s):  
Senthil Rethinam ◽  
Bahri Basaran ◽  
Sumathi Vijayan ◽  
Ali Mert ◽  
Oğuz Bayraktar ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Application ◽  
Tissue Engineering Application ◽  
New Approach ◽  
Bone Tissue Engineering Application

scholarly journals Binary Biocompatible CNC–Gelatine Hydrogel as 3D Scaffolds Suitable for Cell Culture Adhesion and Growth

Applied Nano ◽  
2021 ◽  
Vol 2 (2) ◽  
pp. 118-127
Author(s):  
Luca Zoia ◽  
Anna Binda ◽  
Laura Cipolla ◽  
Ilaria Rivolta ◽  
Barbara La Ferla
Keyword(s):  
Tissue Engineering ◽  
Cell Culture ◽  
Cell Cultures ◽  
Cellulose Nanocrystals ◽  
Potential Application ◽  
Chemical Properties ◽  
Cellular Adhesion ◽  
Chemical Crosslinking ◽  
3D Scaffolds ◽  
Physical Chemical

Binary nano-biocomposite 3D scaffolds of cellulose nanocrystals (CNCs)—gelatine were fabricated without using chemical crosslinking additives. Controlled oxidative treatment allowed introducing carboxyl or carbonyl functionalities on the surface of CNCs responsible for the crosslinking of gelatine polymers. The obtained composites were characterized for their physical-chemical properties. Their biocompatibility towards different cell cultures was evaluated through MTT and LDH assays, cellular adhesion and proliferation experiments. Gelatine composites reinforced with carbonyl-modified CNCs showed the most performing swelling/degradation profile and the most promising adhesion and proliferation properties towards cell lines, suggesting their potential application in the field of tissue engineering.

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