Synthetic routes to benzosuberone-based fused- and spiro-heterocyclic ring systems

RSC Advances ◽  
2016 ◽  
Vol 6 (22) ◽  
pp. 17955-17979 ◽  
Author(s):  
Thoraya A. Farghaly ◽  
Sobhi M. Gomha ◽  
Kamal M. Dawood ◽  
Mohamed R. Shaaban
Keyword(s):  
Pharmaceutical Compounds ◽  
Heterocyclic Ring ◽  
Present Review ◽  
Important Class ◽  
Ring Systems ◽  
Synthetic Routes

Benzosuberones are an important class of medicinal and pharmaceutical compounds and have recently attracted considerable attention. The present review highlights the progress in the synthesis of benzosuberones and their fused and spiro ring systems up to 2015.

ChemInform Abstract: Synthetic Routes to Benzosuberone-Based Fused- and Spiro-Heterocyclic Ring Systems

ChemInform ◽  
2016 ◽  
Vol 47 (15) ◽  
pp. no-no
Author(s):  
Thoraya A. Farghaly ◽  
Sobhi M. Gomha ◽  
Kamal M. Dawood ◽  
Mohamed R. Shaaban
Keyword(s):  
Heterocyclic Ring ◽  
Ring Systems ◽  
Synthetic Routes

Total synthesis of biologically active alkaloids using transition metals

2010 ◽  
Vol 82 (11) ◽  
pp. 1975-1991 ◽  
Author(s):  
Ronny Forke ◽  
Konstanze K. Gruner ◽  
Kerstin E. Knott ◽  
Stefan Auschill ◽  
Sameer Agarwal ◽  
...  
Keyword(s):  
Transition Metals ◽  
Total Synthesis ◽  
Binding Site ◽  
Heterocyclic Ring ◽  
Myosin Atpase ◽  
Biologically Active ◽  
Ring Systems ◽  
Atpase Inhibitors ◽  
Synthetic Routes ◽  
Carbazole Alkaloids

We have developed efficient synthetic routes to heterocyclic ring systems using transition metals (palladium, iron, and silver). Recent applications of this chemistry to the total synthesis of biologically active alkaloids include carbazole alkaloids (pityriazole, euchrestifoline, the antiostatins), crispine A, pentabromo- and pentachloropseudilin. The two latter alkaloids represent a novel class of myosin ATPase inhibitors that led to the discovery of a new allosteric binding site of the protein.

Recent advances in synthesis and reactions of β-amino-α,β-enones (enaminones)

2021 ◽  
Vol 18 ◽  
Author(s):  
Thoraya Farghaly ◽  
Alaa M. Abo Alnaja ◽  
Mohamed R. Shaaban
Keyword(s):  
Carbonyl Compounds ◽  
Heterocyclic Compounds ◽  
Heterocyclic Ring ◽  
Ring Systems ◽  
Organic Syntheses ◽  
Recent Advances ◽  
Synthetic Routes

Abstract: β-Amino-α,β-enones or β-enamino carbonyl compounds are versatile synthons intermediates for the construction of various bio-active heterocyclic compounds and have been established as multipurpose synthetic precursors in organic syntheses and in pharmaceutical developments. In this work, we will discuss the different synthetic routes to obtain β-Amino-α,β-enones or β-enamino carbonyl compounds, their reactions, and their utility in the construction of organic frameworks and heterocyclic ring systems. Structurally, β-amino-α,β-enones are attractive intermediates that syndicate the ambident behaviours of nucleophilicity and electrophilicity of enones simultaneously. β-amino-α,β-enones have been known as acceptors in both 1,2- and 1,4- additions, which make them good intermediate compounds for annulation to different heterocycles.

scholarly journals An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles

2013 ◽  
Vol 9 ◽  
pp. 2265-2319 ◽  
Author(s):  
Marcus Baumann ◽  
Ian R Baxendale
Keyword(s):  
Pharmaceutical Compounds ◽  
Heterocyclic Ring ◽  
Reference Source ◽  
Scientific Journals ◽  
Drug Molecules ◽  
Patent Literature ◽  
Synthetic Routes

This review which is the second in this series summarises the most common synthetic routes as applied to the preparation of many modern pharmaceutical compounds categorised as containing a six-membered heterocyclic ring. The reported examples are based on the top retailing drug molecules combining synthetic information from both scientific journals and the wider patent literature. It is hoped that this compilation, in combination with the previously published review on five-membered rings, will form a comprehensive foundation and reference source for individuals interested in medicinal, synthetic and preparative chemistry.

Synthesis of Pyrimidine-Annulated Five-Membered Heterocycles: An Overview

2019 ◽  
Vol 23 (20) ◽  
pp. 2204-2269 ◽  
Author(s):  
Pradip Kumar Maji
Keyword(s):  
Heterocyclic Ring ◽  
Pyrimidine Ring ◽  
Ring Systems ◽  
Synthetic Routes

This review describes the non-exhaustive scenery of the synthesis of various biologically interesting pyrimidine annulated five-membered heterocyclic ring systems that have been appeared in the literature during the last two decades. During this period, different synthetic routes and various methodologies have been developed for the functionalization of pyrimidine ring towards the construction of five-membered heterocyclic rings. The aim of this review is to give an overview of the assorted methodologies that have been reported about the chemistry of construction of pyrimidines annulated nitrogen, oxygen and sulphur containing five-membered heterocycles.

Novel GABAA Agonist Entities: Pharmacological Investigation and Molecular Modeling Study of Thiazolo- and Thiadiazolo-[3,2-a][1,3] diazepine Analogs

2020 ◽  
Vol 21 ◽  
Author(s):  
Hussein I. El-Subbagh
Keyword(s):  
Molecular Modeling ◽  
Drug Development ◽  
Biological Evaluation ◽  
Neuromuscular Blocking ◽  
Present Review ◽  
Pharmacological Investigation ◽  
Important Class ◽  
Pharmacological Activities ◽  
Short Acting ◽  
New Drug Development

Abstract:: Thiazolo- and thiadiazolo-[3,2-a][1,3]diazepines and their patented derivatives, tested with diverse CNS pharmacological activities, constitute an important class of compounds for new drug development. Therefore, research efforts were continued to design, synthesize, and evaluate compounds for their ultra-short, short-acting hypnotic, anticonvulsant, and neuromuscular blocking activities. The present review provides a summary of the work accomplished by these heterocycles and their biological evaluation.

Sign in / Sign up

Export Citation Format

Share Document