Development of a multiple reaction monitoring (MRM) method based on high performance liquid chromatography/tandem mass spectrometry to analyze in vivo exposure profiles of complex herbal components independent of standards

RSC Advances ◽  
2016 ◽  
Vol 6 (23) ◽  
pp. 19357-19371
Author(s):  
Tong Xie ◽  
An Kang ◽  
Jianya Xu ◽  
Cunsi Shen ◽  
Xia Zhao ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Performance ◽  
Multiple Reaction Monitoring ◽  
Tandem Mass ◽  
Reaction Monitoring ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Herbal Components ◽  
Pharmacokinetic Evaluation

Exposure profiles of herbal componentsin vivoplay pivotal roles in pharmacodynamic and pharmacokinetic evaluation. The proposed MRM method has enabled profile exposure components, time and relative levels accurately.

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