In vivo assessment of newly synthesized achiral copper(ii) and zinc(ii) complexes of a benzimidazole derived scaffold as a potential analgesic, antipyretic and anti-inflammatory

RSC Advances ◽  
2016 ◽  
Vol 6 (23) ◽  
pp. 19475-19481 ◽  
Author(s):  
Mohamed F. AlAjmi ◽  
Afzal Hussain ◽  
Ali Alsalme ◽  
Rais Ahmad Khan
Keyword(s):  
Spectroscopic Techniques ◽  
Anti Inflammatory ◽  
In Vivo Assessment

Two new complexes of copper(ii) and zinc(ii) were synthesized and characterized using various spectroscopic techniques. The newly synthesized compounds were screened for analgesic, antipyretic and anti-inflammatory activities.

2-Substituted Benzoxazoles as Potent Anti-Inflammatory Agents: Synthesis, Molecular Docking and In Vivo Anti-Ulcerogenic Studies

2021 ◽  
Vol 18 ◽  
Author(s):  
Iqra Hamid ◽  
Humaira Nadeem ◽  
Sameen Fatima Ansari ◽  
Sonia Khiljee ◽  
Inzamam Abbasi ◽  
...  
Keyword(s):  
Side Effects ◽  
Therapeutic Interventions ◽  
Binding Potential ◽  
Spectroscopic Techniques ◽  
Standard Drug ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Cox 2 Inhibitors ◽  
Protein Pocket

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are the commonly used therapeutic interventions of inflammation and pain that competitively inhibit the cyclooxygenase (COX) enzymes. Several side effects like gastrointestinal and renal toxicities are associated with the use of these drugs. The therapeutic anti-inflammatory benefits of NSAIDs are produced by the inhibition of COX-2 enzymes, while undesirable side effects arise from the inhibition of COX-1 enzymes. Objectives: In the present study, a new series of 2-substituted benzoxazole derivatives 2(a-f) and 3(a-e) were synthesized in our lab as potent anti-inflammatory agents with outstanding gastro-protective potential. The new analogs 2(a-f) and 3(a-e) were designed depending upon the literature review to serve as ligands for the development of selective COX-2 inhibitors. Methods: The synthesized analogs were characterized using different spectroscopic techniques (FTIR, 1HNMR, 13CNMR) and elemental analysis. All synthesized compounds were screened for their binding potential in the protein pocket of COX-2 and evaluated for their anti-inflammatory potential in animals using the carrageenan-induced paw edema method. Further 5 compounds were selected to assess the in vivo anti-ulcerogenic activity in an ethanol-induced anti-ulcer rat model. Results: Five compounds (2a, 2b, 3a, 3b and 3c) exhibited potent anti-inflammatory activity and significant binding potential in the COX-2 protein pocket. Similarly, these five compounds demonstrated a significant gastro-protective effect (p<0.01) in comparison to the standard drug, Omeprazole. Conclusion: Depending upon our results, we hypothesize that 2-substituted benzoxazole derivatives have excellent potential to serve as candidates for the development of selective anti-inflammatory agents (COX-2 inhibitors). However, further assessments are required to delineate their underlying mechanisms.

Corrigendum to: “In vitro and in vivo assessment of meadowsweet (Filipendula ulmaria ) as anti-inflammatory agent”, Journal of Ethnopharmacology 193 (2016) 627–636

2017 ◽  
Vol 198 ◽  
pp. 608-609
Author(s):  
Jelena Katanić ◽  
Tatjana Boroja ◽  
Vladimir Mihailović ◽  
Stefanie Nikles ◽  
San-Po Pan ◽  
...  
Keyword(s):  
Filipendula Ulmaria ◽  
Inflammatory Agent ◽  
Anti Inflammatory ◽  
In Vivo Assessment

In-vivo Assessment of Antipyretic and Anti-inflammatory Activities of Gymnosporia royleana Extract in Mice

2017 ◽  
Author(s):  
H Khan ◽  
I Khan ◽  
NK Khalil ◽  
A Shahidullah ◽  
A Aziz ◽  
...  
Keyword(s):  
Anti Inflammatory ◽  
In Vivo Assessment

In vitro and in vivo assessment of meadowsweet (Filipendula ulmaria) as anti-inflammatory agent

2016 ◽  
Vol 193 ◽  
pp. 627-636 ◽  
Author(s):  
Jelena Katanić ◽  
Tatjana Boroja ◽  
Vladimir Mihailović ◽  
Stefanie Nikles ◽  
San-Po Pan ◽  
...  
Keyword(s):  
Filipendula Ulmaria ◽  
Inflammatory Agent ◽  
Anti Inflammatory ◽  
In Vivo Assessment

scholarly journals Synthesis and Anti-Inflammatory Activity of Some O-Propargylated-N-acetylpyrazole Derived from 1,3-Diarylpropenones

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Ashwani Kumar Dhingra ◽  
Bhawna Chopra ◽  
Rameshwar Dass ◽  
Sanjeev K. Mittal
Keyword(s):  
Acetic Acid ◽  
Glacial Acetic Acid ◽  
Oral Route ◽  
Therapeutic Agents ◽  
Inflammatory Activity ◽  
Spectroscopic Techniques ◽  
Paw Oedema ◽  
Aryl Ketones ◽  
Anti Inflammatory

In search of novel effective potent therapeutic agents delivered by oral route for inflammation treatment, some novel O-propargylated-N-acetylpyrazole analogs (5a–j) were prepared by treating N-acetylpyrazole (4a–j) derived from 1,3-diarylpropenones (3a–j) with propargyl bromide. Claisen-Schmidt condensation of a series of substituted aryl ketones 1 and benzaldehydes 2 in glacial acetic acid afforded 1,3-diarylpropenones which on further treatment with hydrazine hydrate in acetic acid under reflux conditions afforded 1-acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles (4a–j). The products were characterized by using spectroscopic techniques such as IR and NMR. In addition, the in vivo anti-inflammatory activity of the synthesized compounds was determined using the carrageenan-induced paw oedema method in rats.

In vivo anti-inflammatory action evaluation of protease inhibitors from Cecropia hololeuca and their protein profile by electrophoretic and spectroscopic techniques

2022 ◽  
Vol 144 ◽  
pp. 10-17
Author(s):  
Emanuelle G. Machado ◽  
Nerilson M. Lima ◽  
Maria Patricia Nascimento ◽  
Heberson T. Silva ◽  
Cleonice Aparecida Souza ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Protein Profile ◽  
Spectroscopic Techniques ◽  
Anti Inflammatory ◽  
Inflammatory Action
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