Spontaneous osteogenic differentiation of mesenchymal stem cells on electrospun nanofibrous scaffolds

RSC Advances ◽  
2016 ◽  
Vol 6 (26) ◽  
pp. 22144-22152 ◽  
Author(s):  
Ning Zhang ◽  
Qian-Ru Xiao ◽  
Xin-Yao Man ◽  
Hai-Xia Liu ◽  
Lan-Xin Lü ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Signaling Pathways ◽  
Nanofibrous Scaffolds

Hydroxyapatite-containing PHBV nanofibrous scaffolds accelerate osteogenic differentiation of MSCs by activating the related signaling pathways.

Role of Microtubules in Osteogenic Differentiation of Mesenchymal Stem Cells on 3D Nanofibrous Scaffolds

2017 ◽  
Vol 3 (4) ◽  
pp. 551-559 ◽  
Author(s):  
Sai Rama Krishna Meka ◽  
Leeba Ann Chacko ◽  
Ashwini Ravi ◽  
Kaushik Chatterjee ◽  
Vaishnavi Ananthanarayanan
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Nanofibrous Scaffolds

scholarly journals Dihydroartemisinin Promotes the Osteogenesis of Human Mesenchymal Stem Cells via the ERK and Wnt/β-Catenin Signaling Pathways

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Licheng Ni ◽  
Zhihui Kuang ◽  
Zhe Gong ◽  
Deting Xue ◽  
Qiang Zheng
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Signaling Pathways ◽  
Artemisia Annua ◽  
Human Mesenchymal Stem Cells ◽  
Biological Functions ◽  
Low Toxicity ◽  
Underlying Mechanisms ◽  
Important Drug

Dihydroartemisinin (DHA), which is considered to be one of the active compounds within Artemisia annua, has extensively been used in recent years as the most effective drug against malaria, having many biological functions including anticancer, antifungal, and immunomodulatory activities. However, DHA plays a role in the regulation of the proliferation and human mesenchymal stem cells (hMSCs) osteogenic differentiation that remains unknown. We explored DHA’s effect on hMSCs’ proliferation as well as the osteogenic differentiation, together with its underlying mechanisms of action. We showed that DHA enhanced osteogenic differentiation but had no significant effect on hMSCs’ proliferation. It probably exerted its functions through the signaling pathways of ERK1/2 as well as Wnt/β. Because DHA has low toxicity and costs, it might be regarded as an important drug for fracture treatment and tissue engineering.

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