scholarly journals Copper(ii) quinolinonato-7-carboxamido complexes as potent antitumor agents with broad spectra and selective effects

RSC Advances ◽  
2016 ◽  
Vol 6 (5) ◽  
pp. 3899-3909 ◽  
Author(s):  
Radka Křikavová ◽  
Ján Vančo ◽  
Zdeněk Trávníček ◽  
Roman Buchtík ◽  
Zdeněk Dvořák
Keyword(s):  
Cancer Cells ◽  
Antitumor Agents ◽  
Human Cancer ◽  
Malignant Cells ◽  
Lower Toxicity ◽  
Human Cancer Cells ◽  
Selective Effects

[Cu(quix)(phen)]NO3·yH2O (quix = 2-(4-amino-3,5-dichlorophenyl)-3-hydroxy-4(1H)-quinolinone-7-carboxamides) showed potent cytotoxicity against human cancer cells, lower toxicity on non-malignant cells, and ability to interact with biomolecules.

Isocarbostyril Alkaloids and their Derivatives as Promising Antitumor Agents

2013 ◽  
Vol 411-414 ◽  
pp. 3150-3153
Author(s):  
Yu Bin Ji ◽  
Jia Zheng ◽  
Ning Chen ◽  
Dong Xue Song ◽  
Yan Dong ◽  
...  
Keyword(s):  
Cancer Cells ◽  
High Efficiency ◽  
Antitumor Agents ◽  
Human Cancer ◽  
Hot Spot ◽  
Human Cells ◽  
Human Cancer Cells ◽  
Basic Nitrogen ◽  
Normal Human ◽  
Low Toxicity

socarbostyril alkaloids is a kind of alkaloid does not contain basic nitrogen atoms and is represented by hydroxylated benzophenanthridone or isoquinolinone types of structure. The most widely known compounds of this group are narciclasine, lycoricidine , and pancratistatin. They have demonstrated to inhibite the proliferation of many human cancer cells, and at the same time have no affect on normal human cells under a certain dose, they have a high efficiency and low toxicity in antitumor area. Now this kind of compound has been a hot spot research to antitumor workers. The present paper reviews the origin and the antitumor function of the Isocarbostyril alkaloids.

Indirubin derivatives inhibit SFKs/Stat signaling associated with apoptosis in human cancer cells

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
S Nam ◽  
R Buettner ◽  
X Liu ◽  
J Turkson ◽  
D Kim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Stat Signaling

Antiproliferation Effects of Germinated-Korean Rough Rice Extract on Human Cancer Cells

2010 ◽  
Vol 39 (3) ◽  
pp. 325-330 ◽  
Author(s):  
Hyun-Young Kim ◽  
In-Guk Hwang ◽  
Eun-Mi Joung ◽  
Tae-Myoung Kim ◽  
Dae-Joong Kim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Rough Rice
Sign in / Sign up

Export Citation Format

Share Document