Diastereoselective synthesis of 3,3-dimethylazetidines via an intramolecular iodine-mediated cyclization reaction

RSC Advances ◽  
2016 ◽  
Vol 6 (18) ◽  
pp. 15035-15038 ◽  
Author(s):  
Hai-Shan Jin ◽  
Rui Sun ◽  
Wei Zhou ◽  
Li-Ming Zhao
Keyword(s):  
Intramolecular Cyclization ◽  
Cyclization Reaction ◽  
Diastereoselective Synthesis ◽  
Convenient Route

An iodine-mediated intramolecular cyclization reaction of γ-prenylated amines has been developed to provide a convenient route to 3,3-dimethylazetidines.

ChemInform Abstract: Efficient Synthesis of 2,8-Diazabicyclo(4.3.0)nonane Derivatives via Intramolecular Cyclization Reaction.

ChemInform ◽  
2010 ◽  
Vol 27 (7) ◽  
pp. no-no
Author(s):  
J. W. LEE ◽  
H. J. SON ◽  
J. H. LEE ◽  
Y. E. JUNG ◽  
G. J. YOON ◽  
...  
Keyword(s):  
Intramolecular Cyclization ◽  
Cyclization Reaction ◽  
Efficient Synthesis

Stereoselective synthesis of O-tosyl azabicyclic derivatives via aza Prins reaction of endocyclic N-acyliminium ions: application to the total synthesis of (±)-epi-indolizidine 167B and 209D

2014 ◽  
Vol 12 (36) ◽  
pp. 7026-7035 ◽  
Author(s):  
Anil K. Saikia ◽  
Kiran Indukuri ◽  
Jagadish Das
Keyword(s):  
Total Synthesis ◽  
Stereoselective Synthesis ◽  
Cyclization Reaction ◽  
Diastereoselective Synthesis ◽  
Prins Reaction ◽  
Prins Cyclization ◽  
Acyliminium Ions

A diastereoselective synthesis of 4-O-tosyl piperidine containing azabicyclic derivatives has been established via Prins cyclization reaction. This protocol has been applied for the total synthesis of (±)-epi-indolizidine 167B and 209D.

Nerve agent simulant diethyl chlorophosphate detection using a cyclization reaction approach with high stokes shift system

2017 ◽  
Vol 41 (4) ◽  
pp. 1653-1658 ◽  
Author(s):  
Yoon Jeong Jang ◽  
Sandip V. Mulay ◽  
Youngsam Kim ◽  
Perman Jorayev ◽  
David G. Churchill
Keyword(s):  
Fluorescent Probe ◽  
Intramolecular Cyclization ◽  
Stokes Shift ◽  
Nerve Agent ◽  
Cyclization Reaction ◽  
Selective Detection ◽  
Turn On ◽  
System P

A intramolecular cyclization reaction-based “turn-on” fluorescent probe (CoumNMe2) for selective detection of diethyl chlorophosphate (DCP) over close competitors diethyl cyanophosphonate (DECP), and diethyl methylphosphonate (DEMP) was developed.

scholarly journals A Synthesis of 4-Chloro-2-(trichloromethyl)pyrimidines and Their Study in Nucleophilic Substitution

Synthesis ◽  
2018 ◽  
Vol 51 (02) ◽  
pp. 530-537 ◽  
Author(s):  
Moisés Romero-Ortega ◽  
Michelle Trujillo-Lagunas ◽  
Ignacio Medina-Mercado ◽  
Ivann Zaragoza-Galicia ◽  
Horacio Olivo
Keyword(s):  
Nucleophilic Substitution ◽  
Intramolecular Cyclization ◽  
Nitrogen Heterocycles ◽  
Cyclization Reaction ◽  
Substitution Reactions ◽  
Pyrimidine Derivatives ◽  
One Pot ◽  
Acyl Chlorides ◽  
Nucleophilic Substitution Reactions ◽  
One Pot Synthesis

A convenient two-step, one-pot synthesis of 4-chloro-2-(trichloromethyl)pyrimidines starting from 2-(trichloromethyl)-1,3-diazabutadienes is described. These nitrogen heterocycles were prepared by a sequential acylation/intramolecular cyclization reaction between 2-(trichloromethyl)-1,3-diazabutadienes and acyl chlorides in the presence of triethylamine followed by treatment with POCl3. This is the first report for the synthesis of this type of 4-chloro-2-(trichloromethyl)pyrimidine derivatives and serves as a source for a wide variety of other substituted pyrimidines by nucleophilic substitution reactions.

Prodrug Forms of Peptidomimetic HIV Protease Inhibitors Using Intramolecular Cyclization Reaction

2001 ◽  
pp. 650-651
Author(s):  
Yoshiaki Kiso ◽  
Hikaru Matsumoto ◽  
Tomonori Hamawaki ◽  
Youhei Sohma ◽  
Tooru Kimura ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Intramolecular Cyclization ◽  
Cyclization Reaction ◽  
Hiv Protease ◽  
Hiv Protease Inhibitors
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