Synthesis, molecular structure and electrochemical properties of nickel(ii) benzhydrazone complexes: influence of ligand substitution on DNA/protein interaction, antioxidant activity and cytotoxicity

RSC Advances ◽  
2015 ◽  
Vol 5 (123) ◽  
pp. 101932-101948 ◽  
Author(s):  
Ramasamy Raj Kumar ◽  
Rengan Ramesh
Keyword(s):  
Molecular Structure ◽  
Antioxidant Activity ◽  
Protein Binding ◽  
Electrochemical Properties ◽  
Cancer Cells ◽  
Protein Interaction ◽  
Ligand Substitution ◽  
Dna Protein Interaction ◽  
Apoptosis In Cancer Cells

Four new nickel(ii) benzhydrazone complexes were synthesized and characterized. The influence of ligand substitution on DNA/protein binding, antioxidant activity and cytotoxicity is described. The complexes are able to induce apoptosis in cancer cells.

scholarly journals The effect of incorporating carboxylic acid functionalities into 2,2′-bipyridine on the biological activity of the complexes formed: synthesis, structure, DNA/protein interaction, antioxidant activity and cytotoxicity

RSC Advances ◽  
2017 ◽  
Vol 7 (27) ◽  
pp. 16428-16443 ◽  
Author(s):  
Thangavel Sathiya Kamatchi ◽  
Nataraj Chitrapriya ◽  
Sarvana Loganthan Ashok Kumar ◽  
Jang Yoon Jung ◽  
Horst Puschmann ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Biological Activity ◽  
Carboxylic Acid ◽  
Protein Binding ◽  
Binding Affinity ◽  
Protein Interaction ◽  
Acid Group ◽  
Carboxylic Acid Group ◽  
Dna Protein Interaction

Incorporation of carboxylic acid group in the bipyridine moiety has resulted in showing differences in DNA/protein binding affinity, efficiency in antioxidant activity and cytotoxicity.

scholarly journals Ni(ii) and Co(ii) complexes of an asymmetrical aroylhydrazone: synthesis, molecular structures, DNA binding, protein interaction, radical scavenging and cytotoxic activity

RSC Advances ◽  
2017 ◽  
Vol 7 (66) ◽  
pp. 41527-41539 ◽  
Author(s):  
Yueqin Li ◽  
Zhiwei Yang ◽  
Minya Zhou ◽  
Yun Li ◽  
Jing He ◽  
...  
Keyword(s):  
Dna Binding ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Protein Interaction ◽  
Binding Protein ◽  
Radical Scavenging ◽  
Dna Binding Protein ◽  
Molecular Structures ◽  
Bsa Binding ◽  
Apoptosis In Cancer Cells

The DNA/BSA binding, antioxidant and cytotoxic activity of Ni(ii) and Co(ii) complexes bearing aroylhydrazone were investigated to induce apoptosis in cancer cells.

Angler Peptides: Macrocyclic Conjugates Inhibit p53:MDM2/X Interactions and Activate Apoptosis in Cancer Cells

2021 ◽  
Vol 16 (2) ◽  
pp. 414-428
Author(s):  
Grégoire J.-B. Philippe ◽  
Anna Mittermeier ◽  
Nicole Lawrence ◽  
Yen-Hua Huang ◽  
Nicholas D. Condon ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Apoptosis In Cancer Cells

Novel small molecule inhibitor of Kpnβ1 induces cell cycle arrest and apoptosis in cancer cells

2021 ◽  
pp. 112637
Author(s):  
Aderonke Ajayi-Smith ◽  
Pauline van der Watt ◽  
Nonkululeko Mkwanazi ◽  
Sarah Carden ◽  
John O. Trent ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Cycle Arrest ◽  
Molecule Inhibitor ◽  
Apoptosis In Cancer Cells

Weakening of DNA-protein interaction in cultured human fibroblasts induced by chemical mutagens

1987 ◽  
Vol 104 (6) ◽  
pp. 1730-1732
Author(s):  
A. I. Gorin ◽  
N. S. Bogomolova ◽  
A. V. Ermakov ◽  
M. I. Freidin ◽  
V. A. Chernov ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Human Fibroblasts ◽  
Chemical Mutagens ◽  
Cultured Human Fibroblasts ◽  
Dna Protein Interaction

Phytochemical concentrations and biological activities of Sorghum bicolor alcoholic extracts

2016 ◽  
Vol 7 (8) ◽  
pp. 3410-3420 ◽  
Author(s):  
Vermont P. Dia ◽  
Philipus Pangloli ◽  
Lynsey Jones ◽  
Angela McClure ◽  
Anjali Patel
Keyword(s):  
Ovarian Cancer ◽  
Antioxidant Activity ◽  
Sorghum Bicolor ◽  
Cancer Cells ◽  
Biological Activities ◽  
Ovarian Cancer Cells

Sorghum alcoholic extracts exhibited antioxidant activity and capability to inhibit and chemosensitize ovarian cancer cells in vitro.

NF-κB p65 recruited SHP regulates PDCD5-mediated apoptosis in cancer cells

APOPTOSIS ◽  
2013 ◽  
Vol 19 (3) ◽  
pp. 506-517 ◽  
Author(s):  
Farhan Murshed ◽  
Lulu Farhana ◽  
Marcia I. Dawson ◽  
Joseph A. Fontana
Keyword(s):  
Cancer Cells ◽  
Apoptosis In Cancer Cells
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