Synthesis, biological evaluation and mechanism study of a class of cyclic combretastatin A-4 analogues as novel antitumour agents

RSC Advances ◽  
2015 ◽  
Vol 5 (119) ◽  
pp. 98527-98537 ◽  
Author(s):  
Jun Yan ◽  
Yanqing Pang ◽  
Jie Chen ◽  
Jianfei Sheng ◽  
Jinhui Hu ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Biological Evaluation ◽  
Amide Group ◽  
Mechanism Study ◽  
Antitumour Agents ◽  
Microtubule Inhibitors ◽  
Group A ◽  
Ring Condensation

In the search for novel antitumor agents, a series of cyclic CA-4 analogues bearing amide group, A–B or B–C ring condensation, and CC or CN bond in the B ring were designed, synthesized and identified as microtubule inhibitors.

Synthesis and Biological Evaluation of Diaryl Ether Linked DC-81 Conjugates as Potential Antitumor Agents

2013 ◽  
Vol 13 (10) ◽  
pp. 1590-1600 ◽  
Author(s):  
Ahmed Kamal ◽  
A. Viswanath ◽  
M. Ramaiah ◽  
J. Murty ◽  
Farheen Sultana ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Biological Evaluation ◽  
Diaryl Ether ◽  
Synthesis And Biological Evaluation ◽  
Potential Antitumor

Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents

2011 ◽  
Vol 46 (12) ◽  
pp. 5970-5977 ◽  
Author(s):  
Hongbin Zou ◽  
Liang Zhang ◽  
Jingfeng Ouyang ◽  
Marc A. Giulianotti ◽  
Yongping Yu
Keyword(s):  
Antitumor Agents ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation ◽  
Potential Antitumor

ChemInform Abstract: Antitumor Agents. Part 202. Novel 2′-Amino Chalcones: Design, Synthesis, and Biological Evaluation.

ChemInform ◽  
2010 ◽  
Vol 31 (29) ◽  
pp. no-no
Author(s):  
Yi Xia ◽  
Zheng-Yu Yang ◽  
Peng Xia ◽  
Kenneth F. Bastow ◽  
Yuka Nakanishi ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation
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