T 1-weighted and T2-weighted MRI probe based on Gd-DTPA surface conjugated SPIO nanomicelles

RSC Advances ◽  
2015 ◽  
Vol 5 (118) ◽  
pp. 97675-97680 ◽  
Author(s):  
Waiou Zhao ◽  
Hailong Huang ◽  
Yuan Sun ◽  
Xiaonan Zhang ◽  
Yapeng Li ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Half Life ◽  
Superparamagnetic Iron Oxide ◽  
Life Time ◽  
Gadolinium Chelate

Herein we report novel gadolinium chelate surface conjugated superparamagnetic iron oxide (SPIO) nanomicelles which can achieve T1-weighted and T2-weighted MR imaging simultaneously and lengthen the half life time.

DYNAMIC MR IMAGING, BIODISTRIBUTION AND PHARMACOKINETICS OF POLYMER SHELLED MICROBUBBLES CONTAINING SPION

NANO ◽  
2014 ◽  
Vol 09 (06) ◽  
pp. 1450069 ◽  
Author(s):  
ÅSA BARREFELT ◽  
GAIO PARADOSSI ◽  
HEBA ASEM ◽  
SILVIA MARGHERITELLI ◽  
MARYAM SAGHAFIAN ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Half Life ◽  
Superparamagnetic Iron Oxide ◽  
Individual Variability ◽  
Mri Contrast Agent ◽  
Blue Staining ◽  
Pharmacokinetic Parameters ◽  
Tissue Samples ◽  
Over Time

Magnetic Resonance Imaging (MRI) is a noninvasive diagnostic method that provides information on morphological and physiological changes of the internal organs over time. Imaging and measurements can be repeated on the same subject, thereby reducing inter-individual variability effects and hence the number of subjects required. A potential MRI contrast agent consisting of microbubbles embedded with superparamagnetic iron oxide nanoparticles (SPION) in the shell (SPION MBs) was injected intravenously into rats to determine their biodistribution and pharmacokinetics using MR imaging. Agarose phantoms containing SPION MBs were scanned using 3 T MRI to construct a standard curve. Rats were injected with SPION MBs, free SPION or plain MBs and scanned dynamically at 3 T using a clinical MR scanner. The relaxation rate (R2*) was studied over time as a measure of the iron oxide concentrations to enable calculation of the pharmacokinetic parameters. The kinetics of SPION MBs in the liver was fitted to a one-compartment model. Furthermore, the biological fate of SPION MBs was examined via a histological survey of tissue samples using Perls' Prussian blue staining and immunohistochemistry (IHC). 1.2 h after injection of SPION MBs, T2* of the liver had decreased to its minimum. The elimination half-life of SPION MBs was 598.2 ± 97.3 h, while the half-life for SPION was 222.6 ± 26.4 h. Moreover, our study showed that SPION MBs were taken up by the macrophages in the lungs, spleen and liver. MBs labeled with SPION can be used for MR imaging. Moreover, MRI is a reliable and noninvasive tool that can be utilized in pharmacokinetic investigations of future contrast agents using SPION MBs and SPION in the rat.

MR imaging with i.v. superparamagnetic iron oxide: efficacy in the detection of focal hepatic lesions.

1993 ◽  
Vol 161 (6) ◽  
pp. 1191-1198 ◽  
Author(s):  
T C Winter ◽  
P C Freeny ◽  
H V Nghiem ◽  
L A Mack ◽  
R M Patten ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Superparamagnetic Iron Oxide ◽  
Focal Hepatic Lesions ◽  
Hepatic Lesions

Superparamagnetic Iron Oxide Enhanced MR Imaging: Influence of Hepatic Dysfunction in Cirrhotic Patients

2000 ◽  
Vol 43 (3) ◽  
pp. 319
Author(s):  
Hyo Sung Kwak ◽  
Jeong Min Lee ◽  
Seong Hee Ym ◽  
Chong Soo Kim ◽  
Hyun Young Han
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Hepatic Dysfunction ◽  
Superparamagnetic Iron Oxide ◽  
Cirrhotic Patients

MR imaging of murine arthritis using ultrasmall superparamagnetic iron oxide particles☆

2001 ◽  
Vol 19 (9) ◽  
pp. 1209-1216 ◽  
Author(s):  
Bernard J Dardzinski ◽  
Vincent J Schmithorst ◽  
Scott K Holland ◽  
Gregory P Boivin ◽  
Tomoyuki Imagawa ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Superparamagnetic Iron Oxide ◽  
Iron Oxide Particles ◽  
Ultrasmall Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Particles ◽  
Oxide Particles

Controllable labelling of stem cells with a novel superparamagnetic iron oxide–loaded cationic nanovesicle for MR imaging

2012 ◽  
Vol 22 (11) ◽  
pp. 2328-2337 ◽  
Author(s):  
Ruo Mi Guo ◽  
Nuo Cao ◽  
Fang Zhang ◽  
Yi Ru Wang ◽  
Xue Hua Wen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Iron Oxide ◽  
Mr Imaging ◽  
Superparamagnetic Iron Oxide

Superparamagnetic iron oxide: clinical application as a contrast agent for MR imaging of the liver.

Radiology ◽  
1988 ◽  
Vol 168 (2) ◽  
pp. 297-301 ◽  
Author(s):  
D D Stark ◽  
R Weissleder ◽  
G Elizondo ◽  
P F Hahn ◽  
S Saini ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Contrast Agent ◽  
Clinical Application ◽  
Superparamagnetic Iron Oxide

Superparamagnetic Iron Oxide Hepatic MR Imaging: Efficacy and Safety Using Conventional and Fast Spin-Echo Pulse Sequences

1995 ◽  
Vol 5 (5) ◽  
pp. 566-570 ◽  
Author(s):  
Lawrence H. Schwartz ◽  
Steven E. Seltzer ◽  
Clare M. C. Tempany ◽  
Stuart G. Silverman ◽  
David R. Piwnica-Worms ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Spin Echo ◽  
Pulse Sequences ◽  
Superparamagnetic Iron Oxide ◽  
Fast Spin Echo ◽  
Efficacy And Safety ◽  
Echo Pulse ◽  
Fast Spin
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