Highly efficient colorimetric detection of cancer cells utilizing Fe-MIL-101 with intrinsic peroxidase-like catalytic activity over a broad pH range

RSC Advances ◽  
2015 ◽  
Vol 5 (119) ◽  
pp. 97910-97917 ◽  
Author(s):  
Daomei Chen ◽  
Bin Li ◽  
Liang Jiang ◽  
Deliang Duan ◽  
Yizhou Li ◽  
...  
Keyword(s):  
Surface Modification ◽  
Catalytic Activity ◽  
Folic Acid ◽  
Cancer Cells ◽  
Colorimetric Assay ◽  
Colorimetric Detection ◽  
Metal Organic Frameworks ◽  
Metal Organic ◽  
Iron Based ◽  
Ph Range

We take advantage of the folic acid conjugated iron-based metal–organic frameworks (Fe-MIL-101) without any surface modification to design a simple and sensitive colorimetric assay to detect cancer cells based on its intrinsic peroxidase-like activity over broad pH range.

scholarly journals Redox-Responsive Tumor Targeted Dual-Drug Loaded Biocompatible Metal-Organic Frameworks for Enhancing Anticancer Cytotoxicity

2020 ◽  
Author(s):  
Chang Liu ◽  
Xiaoyu Xu ◽  
Junnian Zhou ◽  
Jiaqi Yan ◽  
Dongqing Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Cancer Cells ◽  
Metal Organic Frameworks ◽  
Drug Carriers ◽  
Laser Scanning Microscopy ◽  
Dichloroacetic Acid ◽  
Redox Responsive ◽  
Metal Organic ◽  
Dual Drug

Abstract Metal-organic frameworks (MOFs) have proven to be a promising class of drug carriers due to their high porosity, crystalline properties with defined structure information, and their potential for further functionalization. However, to date, no extensive research has been conducted on MOF-based drug carriers with stimuli-responsive, dual-drug delivery, and tumor targeting functions. Here, we demonstrate the strategy of constructing a redox responsive and tumor-targeted MOF, as dual-drug carrier, by anchoring functional disulfide anhydride and folic acid (FA) molecules to the organic links of MOFs, respectively. The MOF composites show the controlled release of loaded 5-fluorouracil (5-FU) entrapped within UiO-66-NH2 nanostructures modified by dichloroacetic acid (DCA). Moreover, the MOF building block DCA acts as a synergistical drug to 5-FU in cancer cells inhibition. Through disulfide bonds, the gated MOF has redox-responsive drugs release. The confocal laser scanning microscopy further proved that conjugation of folic acid to the MOF surface can significantly enhance the targeting ability to cancer cells and the cancer cell uptake of FA-MOFs. The synthesis of redox-responsive dual-drug delivery MOF hybrids paves the way to assemble of other MOF hybrids that respond to other triggering factors such as light, temperature, pH, or biomarkers. The properties and functions of such materials are expected to influence the development of sensors, new catalysts, photonic devices, and drug delivery carriers.

Water-stable metal–organic frameworks with intrinsic peroxidase-like catalytic activity as a colorimetric biosensing platform

2014 ◽  
Vol 50 (9) ◽  
pp. 1092-1094 ◽  
Author(s):  
Jian-Wei Zhang ◽  
Hao-Tian Zhang ◽  
Zi-Yi Du ◽  
Xueqing Wang ◽  
Shu-Hong Yu ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Catalytic Activity ◽  
Colorimetric Assay ◽  
Metal Organic Frameworks ◽  
Peroxidase Mimics ◽  
Metal Organic ◽  
Colorimetric Biosensing

With Fe(iii)-based metal–organic frameworks (MOFs) as peroxidase mimics, a colorimetric assay to detect H2O2 and ascorbic acid has been established.

scholarly journals Pt Nanoparticles Anchored on NH2-MIL-101 with Efficient Peroxidase-Like Activity for Colorimetric Detection of Dopamine

Chemosensors ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 140
Author(s):  
Jing Li ◽  
Keying Xu ◽  
Yang Chen ◽  
Jie Zhao ◽  
Peiyao Du ◽  
...  
Keyword(s):  
Active Sites ◽  
Clinical Medicine ◽  
Colorimetric Assay ◽  
Colorimetric Detection ◽  
Pt Nanoparticles ◽  
Robust Detection ◽  
Color Changes ◽  
Relevant Role ◽  
Metal Organic ◽  
The Central Nervous System

Dopamine (DA) is an important catecholamine neurotransmitter that plays a highly relevant role in regulating the central nervous system, and abnormal DA content can cause many immune-related diseases. Hence, it is of significance to sensitively and specifically identify DA for clinical medicine. In this work, Pt/NH2-MIL-101 hybrid nanozymes with bimetallic catalytic centers were fabricated by forming coordinate bonds between Pt nanoparticles (Pt NPs) and –NH2 on metal–organic frameworks (MOF). The catalytic activity of Pt/NH2-MIL-101 was increased by 1.5 times via enlarging the exposure of more active sites and improving the activity of the active sites through the strategy of forming bimetallic catalytic centers. In the presence of DA, competing with 3, 3′, 5, 5′-tetramethylbenzidine (TMB) for the generated hydroxyl radicals (•OH), the blue oxidation state TMB (Ox-TMB) is reduced to colorless TMB, showing dramatic color changes. The Pt/NH2-MIL-101-based colorimetric assay enables the sensitive and robust detection of DA molecules with a detection limit of only 0.42 μM and has an observable potential in clinical applications.

Water-stable zirconium and iron-based metal-organic frameworks (MOFs) as fluoride scavengers in aqueous medium

2021 ◽  
Vol 270 ◽  
pp. 118645
Author(s):  
Mohammad Hossien Saghi ◽  
Bruno Chabot ◽  
Shahabaldin Rezania ◽  
Mika Sillanpää ◽  
Ali Akbar Mohammadi ◽  
...  
Keyword(s):  
Aqueous Medium ◽  
Metal Organic Frameworks ◽  
Metal Organic ◽  
Iron Based

Biomimetic Catalysts of Iron–based Metal-Organic Frameworks with High Peroxidase-Mimicking Activity for Colorimetric Biosensing

2021 ◽  
Author(s):  
Xiao-Ning Wang ◽  
Yu-Meng Zhao ◽  
Jialuo Li ◽  
Jiandong Pang ◽  
Qiang Wang ◽  
...  
Keyword(s):  
Metal Organic Frameworks ◽  
Systematic Investigation ◽  
Biomimetic Catalysts ◽  
Biomimetic Catalyst ◽  
Metal Organic ◽  
Iron Based ◽  
Colorimetric Biosensing

The field of Metal-Organic Frameworks (MOFs)-based biomimetic catalyst has achieved great progresses, but is still in its infancy stage. The systematic investigation on the tailored construction of MOF-based biomimetic catalysts...

From Ru nanoparticle-encapsulated metal–organic frameworks to highly catalytically active Cu/Ru nanoparticle-embedded porous carbon

2017 ◽  
Vol 5 (10) ◽  
pp. 4835-4841 ◽  
Author(s):  
Pradip Pachfule ◽  
Xinchun Yang ◽  
Qi-Long Zhu ◽  
Nobuko Tsumori ◽  
Takeyuki Uchida ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
High Temperature ◽  
Porous Carbon ◽  
Metal Organic Frameworks ◽  
Ammonia Borane ◽  
Carbon Composites ◽  
High Catalytic Activity ◽  
Catalytically Active ◽  
Metal Organic

High-temperature pyrolysis of Ru nanoparticle-encapsulated MOF (Ru@HKUST-1) afforded ultrafine Cu/Ru nanoparticle-embedded porous carbon composites (Cu/Ru@C), which show high catalytic activity for ammonia borane hydrolysis.

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