Atomic force microscopy for dynamic observation of human erythrocytes in a microfluidic system

RSC Advances ◽  
2015 ◽  
Vol 5 (123) ◽  
pp. 101319-101326 ◽  
Author(s):  
Feng-Jia Kuo ◽  
Mon-Shu Ho ◽  
Jane Dai ◽  
Ming-Huisung Fan
Keyword(s):  
Drug Delivery ◽  
Atomic Force Microscopy ◽  
Human Erythrocyte ◽  
Microfluidic System ◽  
Rapid Evaluation ◽  
Force Microscopy ◽  
Atomic Force ◽  
Dynamic Observation ◽  
System P

This study investigated the possibility of using atomic force microscopy (AFM) as a drug delivery system as well as a means to manipulate individual cells in an open microfluidic system for the rapid evaluation of human erythrocyte pathologyin situ.

Atomic force microscopy of in situ deformed nickel thin films

1999 ◽  
Vol 353 (1-2) ◽  
pp. 194-200 ◽  
Author(s):  
C. Coupeau ◽  
J.F. Naud ◽  
F. Cleymand ◽  
P. Goudeau ◽  
J. Grilhé
Keyword(s):  
Thin Films ◽  
Atomic Force Microscopy ◽  
Force Microscopy ◽  
Nickel Thin Films ◽  
Atomic Force

scholarly journals Degradation Mechanism of Porous Metal-Organic Frameworks by In Situ Atomic Force Microscopy

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 722
Author(s):  
Ioanna Christodoulou ◽  
Tom Bourguignon ◽  
Xue Li ◽  
Gilles Patriarche ◽  
Christian Serre ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Degradation Mechanism ◽  
Metal Organic Frameworks ◽  
Porous Metal ◽  
Force Microscopy ◽  
Atomic Force ◽  
Metal Organic ◽  
The Media ◽  
Ph Conditions

In recent years, Metal-Organic Frameworks (MOFs) have attracted a growing interest for biomedical applications. The design of MOFs should take into consideration the subtle balance between stability and biodegradability. However, only few studies have focused on the MOFs’ stability in physiological media and their degradation mechanism. Here, we investigate the degradation of mesoporous iron (III) carboxylate MOFs, which are among the most employed MOFs for drug delivery, by a set of complementary methods. In situ AFM allowed monitoring with nanoscale resolution the morphological, dimensional, and mechanical properties of a series of MOFs in phosphate buffer saline and in real time. Depending on the synthetic route, the external surface presented either well-defined crystalline planes or initial defects, which influenced the degradation mechanism of the particles. Moreover, MOF stability was investigated under different pH conditions, from acidic to neutral. Interestingly, despite pronounced erosion, especially at neutral pH, the dimensions of the crystals were unchanged. It was revealed that the external surfaces of MOF crystals rapidly respond to in situ changes of the composition of the media they are in contact with. These observations are of a crucial importance for the design of nanosized MOFs for drug delivery applications.

Use of in-situ atomic force microscopy to monitor the biodegradation of polyhydroxyalkanoates (PHAs)

2001 ◽  
Vol 167 (1) ◽  
pp. 139-151 ◽  
Author(s):  
Connie J. Rossini ◽  
Justinn F. Arceo ◽  
Evan R. McCarney ◽  
Brian H. Augustine ◽  
Douglas E. Dennis ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Force Microscopy ◽  
Atomic Force

Surface morphology of As-deposited and laser-damaged dielectric mirror coatings studied in-situ by atomic force microscopy

1992 ◽  
Author(s):  
Mark R. Kozlowski ◽  
Michael C. Staggs ◽  
Mehdi Balooch ◽  
Robert J. Tench ◽  
Wigbert J. Siekhaus
Keyword(s):  
Atomic Force Microscopy ◽  
Surface Morphology ◽  
Force Microscopy ◽  
Dielectric Mirror ◽  
Atomic Force

Procaine Effect on Human Erythrocyte Membrane Explored by Atomic Force Microscopy

2011 ◽  
Vol 14 (4) ◽  
pp. 237-247 ◽  
Author(s):  
Ulpiu Vlad Zdrenghea ◽  
Gheorghe Tomoaia ◽  
Daniela-Vasilica Pop-Toader ◽  
Aurora Mocanu ◽  
Ossi Horovitz ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Erythrocyte Membrane ◽  
Human Erythrocyte ◽  
Human Erythrocyte Membrane ◽  
Force Microscopy ◽  
Atomic Force
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