Synthesis, spectral characterization, structural studies, molecular docking and antimicrobial evaluation of new dioxidouranium(vi) complexes incorporating tetradentate N2O2 Schiff base ligands

RSC Advances ◽  
2015 ◽  
Vol 5 (115) ◽  
pp. 95104-95117 ◽  
Author(s):  
S. Yousef Ebrahimipour ◽  
Iran Sheikhshoaie ◽  
Jesús Castro ◽  
Michal Dušek ◽  
Zeinab Tohidiyan ◽  
...  
Keyword(s):  
Schiff Base ◽  
Molecular Docking ◽  
Antimicrobial Activities ◽  
Spectral Characterization ◽  
Schiff Base Complexes ◽  
Spectroscopic Methods ◽  
Structural Studies ◽  
Schiff Base Ligands ◽  
Antimicrobial Evaluation

Two new uranyl(vi) Schiff base complexes were synthesized and characterized by physicochemical and spectroscopic methods. The antimicrobial activities of these complexes were also investigated against microorganisms.

scholarly journals Polydentate Schiff Base Ligands and Their La(III) Complexes: Synthesis, Characterization, Antibacterial, Thermal, and Electrochemical Properties

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Ali E. Şabik ◽  
Muharrem Karabörk ◽  
Gökhan Ceyhan ◽  
Mehmet Tümer ◽  
Metin Dığrak
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Base ◽  
Electrochemical Properties ◽  
Antimicrobial Activities ◽  
Nitrogen Atmosphere ◽  
Spectroscopic Methods ◽  
Schiff Base Ligands ◽  
One Step ◽  
The One ◽  
Reversible Transfer

We synthesized the Schiff base ligands H2L1–H2L4 and their La(III) complexes and characterized them by the analytical and spectroscopic methods. We investigated their electrochemical and antimicrobial activity properties. The electrochemical properties of the ligands H2L1–H2L4 and their La(III) complexes were studied at the different scan rates (100 and 200 mV), different pH ranges (), and in the different solvents. The electrooxidation of the Schiff base ligands involves a reversible transfer of two electrons and two protons in solutions of pH up to 5.5, in agreement with the one-step two-electron mechanism. In solutions of pH higher than 5.5, the process of electrooxidation reaction of the Schiff base ligands and their La(III) complexes follows an ECi mechanism. The antimicrobial activities of the ligands and their complexes were studied. The thermal properties of the metal complexes were studied under nitrogen atmosphere in the range of temperature 20–1000°C.

Molecular docking, DNA binding, thermal studies and antimicrobial activities of Schiff base complexes

2016 ◽  
Vol 218 ◽  
pp. 434-456 ◽  
Author(s):  
A.Z. El-Sonbati ◽  
M.A. Diab ◽  
A.A. El-Bindary ◽  
M.I. Abou-Dobara ◽  
H.A. Seyam
Keyword(s):  
Schiff Base ◽  
Molecular Docking ◽  
Dna Binding ◽  
Thermal Studies ◽  
Antimicrobial Activities ◽  
Schiff Base Complexes

scholarly journals SYNTHESIS, SPECTRAL CHARACTERIZATION OF SCHIFF BASE COMPLEXES BASED ON PYRIMIDINE MOIETY WITH MOLECULAR DOCKING WITH BIOMOLECULES

2018 ◽  
Vol 11 (10) ◽  
pp. 93
Author(s):  
Mohanambal D ◽  
Arulantony S
Keyword(s):  
Schiff Base ◽  
Molecular Docking ◽  
Cancer Cells ◽  
Elemental Analysis ◽  
Condensation Reaction ◽  
Spectral Characteristics ◽  
Schiff Base Complexes ◽  
Human Epidermis ◽  
Schiff Base Ligands ◽  
13C Nuclear Magnetic Resonance

Objective: Aim of this study is to synthesize new bidentate complexes of type MX2. nH2O with 4 amino antipyrine and ethyl 4-methyl-2-oxo-6- phenylhexahydropyrimidine-5-carboxylate (DHPM) and to characterize their properties, namely elemental analysis, conductivity measurements, and spectral characteristics and to establish the binding between the Schiff base ligands and complexes with human epidermis cancer cells (Hep-2) through molecular docking.Method: A new bidentate complexes were synthesized by condensation reaction of MX2·nH2O (M = Cu (II), Zn (II), Co (II)) with 4-aminoantipyrine (A) and DHPM in methanol under atmospheric pressure.Results: All the compounds have been characterized by elemental analysis, conductance measurements, magnetic moments, and spectroscopy techniques such as ultraviolet–visible, infrared (IR), 1H and 13C nuclear magnetic resonance, and electron spin resonance (ESR). The IR showed that nature of functional group present in the ligand (Lp) acts as neutral bidentate through the azomethane nitrogen atom and carbonyl oxygen moiety and its complexes formation. The ESR spectral data of copper complex provided information about their structure on the basis of Hamiltonian parameters and degree of covalency. The antimicrobial (Escherichia coli, Salmonella typhi, Bacillus subtilis, and aureus) and antifungal (Candida and Aspergillus niger) activities of the complexes were tested against various microorganism by disc diffusion method.Conclusion: The antimicrobial activity indicates that the metal complexes are more active than the ligand. Molecular docking was used to predict the binding between the Schiff base ligands and complexes with human epidermis cancer cells (Hep-2).

scholarly journals Utilization and simulation of innovative new binuclear Co(ii), Ni(ii), Cu(ii), and Zn(ii) diimine Schiff base complexes in sterilization and coronavirus resistance (Covid-19)

2021 ◽  
Vol 19 (1) ◽  
pp. 772-784
Author(s):  
Moamen S. Refat ◽  
Ahmed Gaber ◽  
Walaa F. Alsanie ◽  
Mohamed I. Kobeasy ◽  
Rozan Zakaria ◽  
...  
Keyword(s):  
Schiff Base ◽  
Molecular Docking ◽  
Metal Ions ◽  
Free Ligand ◽  
Schiff Base Complexes ◽  
Hydroxyl Groups ◽  
Binuclear Complexes ◽  
Central Metal ◽  
H Nmr ◽  
Biological Studies

Abstract This article aimed at the synthesis and molecular docking assessment of new diimine Schiff base ligand, namely 2-((E)-(2-((Z)-2-(4-chlorophenyl)-2-hydroxyvinyl)hydrazono) methyl)-6-methoxyphenol (methoxy-diim), via the condensation of 1-(4-chloro-phenyl)-2-hydrazino-ethenol compound with 2-((E)-(2-((Z)-2-(4-chlorophenyl)-2-hydroxy vinyl) hydrazono)methyl)-6-methoxyphenol in acetic acid as well as the preparation of new binuclear complexes of Co(ii), Ni(ii), Cu(ii), and Zn(ii). The following synthesized complexes were prepared in a ratio of 2:1 (metal/ligand). The 1H-NMR, UV-Vis, and FTIR spectroscopic data; molar conductivity measurements; and microanalytical, XRD, TGA/DTG, and biological studies were carried out to determine the molecular structure of these complexes. According to the spectroscopic analysis, the two central metal ions were coordinated with the diamine ligand via the nitrogen of the hydrazine and oxygen of the hydroxyl groups for the first metal ions and via the nitrogen of the hydrazine and oxygen of the phenol group for the second metal ions. Molecular docking for the free ligand was carried out against the breast cancer 3hb5-oxidoreductase and the 4o1v-protein binding kidney cancer and COVID-19 protease, and good results were obtained.

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