New 13-pyridinealkyl berberine analogues intercalate to DNA and induce apoptosis in HepG2 and MCF-7 cells through ROS mediated p53 dependent pathway: biophysical, biochemical and molecular modeling studies

RSC Advances ◽  
2015 ◽  
Vol 5 (110) ◽  
pp. 90632-90644 ◽  
Author(s):  
Sabyasachi Chatterjee ◽  
Sumana Mallick ◽  
Franco Buzzetti ◽  
Gaetano Fiorillo ◽  
Tanjia Monir Syeda ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Dna Binding ◽  
Modeling Studies ◽  
Modeling Techniques ◽  
Molecular Modeling Studies ◽  
Dependent Pathway ◽  
Mcf 7

A new series of 13-pyridinealkyl berberine analogues was synthesized and their DNA binding efficacy studied by employing spectroscopic, calorimetric and molecular modeling techniques.

Synthesis of Novel C3-Linked β-Carboline-Pyridine Derivatives Employing Khronke Reaction: DNA-binding Ability and Molecular Modeling Studies

2015 ◽  
Vol 12 (999) ◽  
pp. 1-1
Author(s):  
Nagula Shankaraiah ◽  
Pankaj Sharma ◽  
Srinivas Pedapati ◽  
Shalini Nekkanti ◽  
Vunnam Srinivasulu ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Dna Binding ◽  
Pyridine Derivatives ◽  
Binding Ability ◽  
Modeling Studies ◽  
Molecular Modeling Studies

Binding of DNA-binding alkaloids berberine and palmatine to tRNA and comparison to ethidium: Spectroscopic and molecular modeling studies

2008 ◽  
Vol 891 (1-3) ◽  
pp. 498-507 ◽  
Author(s):  
Md. Maidul Islam ◽  
Prateek Pandya ◽  
Sebanti Roy Chowdhury ◽  
Surat Kumar ◽  
Gopinatha Suresh Kumar
Keyword(s):  
Molecular Modeling ◽  
Dna Binding ◽  
Modeling Studies ◽  
Molecular Modeling Studies

Targeting hepatocellular carcinoma: Synthesis of new pyrazole-based derivatives, biological evaluation, DNA binding, and molecular modeling studies

2019 ◽  
Vol 88 ◽  
pp. 102917 ◽  
Author(s):  
Dina M. Omran ◽  
Mariam A. Ghaly ◽  
Shahenda M. El-Messery ◽  
Farid A. Badria ◽  
Ehab Abdel-Latif ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Molecular Modeling ◽  
Dna Binding ◽  
Biological Evaluation ◽  
Modeling Studies ◽  
Molecular Modeling Studies

Experimental and molecular modeling studies on the DNA-binding of diazacyclam-based acrocyclic copper complex

2017 ◽  
Vol 167 ◽  
pp. 7-14 ◽  
Author(s):  
Nahid Shahabadi ◽  
Mohammad Hakimi ◽  
Teimoor Morovati ◽  
Monireh Falsafi ◽  
Soraya Moradi Fili
Keyword(s):  
Molecular Modeling ◽  
Dna Binding ◽  
Copper Complex ◽  
Modeling Studies ◽  
Molecular Modeling Studies

Synthesis of Novel C3-Linked ?-Carboline-Pyridine Derivatives Employing Khronke Reaction: DNA-binding Ability and Molecular Modeling Studies

2016 ◽  
Vol 13 (4) ◽  
pp. 335-342 ◽  
Author(s):  
Nagula Shankaraiah ◽  
Pankaj Sharma ◽  
Srinivas Pedapati ◽  
Shalini Nekkanti ◽  
Vunnam Srinivasulu ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Dna Binding ◽  
Pyridine Derivatives ◽  
Binding Ability ◽  
Modeling Studies ◽  
Molecular Modeling Studies
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