In vitro and in vivo study of a colon-targeting resin microcapsule loading a novel prodrug, 3,4,5-tributyryl shikimic acid

RSC Advances ◽  
2016 ◽  
Vol 6 (20) ◽  
pp. 16882-16890 ◽  
Author(s):  
Kai Dong ◽  
Aiguo Zeng ◽  
Maoling Wang ◽  
Yalin Dong ◽  
Ke Wang ◽  
...  
Keyword(s):  
Treatment Effects ◽  
Shikimic Acid ◽  
In Vivo Study ◽  
Colon Targeting

Prodrugs synthesized by different drugs not only overcome the defects of the original drugs, but also significantly enhance their treatment effects.

scholarly journals An in vitro and in vivo study of plasma treatment effects on oral biofilms

2019 ◽  
Vol 11 (1) ◽  
pp. 1603524 ◽  
Author(s):  
Qing Hong ◽  
Xiaoqing Dong ◽  
Meng Chen ◽  
Hongmin Sun ◽  
Liang Hong ◽  
...  
Keyword(s):  
Plasma Treatment ◽  
Treatment Effects ◽  
In Vivo Study ◽  
Oral Biofilms

scholarly journals Colon Targeting of Naringin for Cytoprotection against Ulcerative Colitis: In Vitro-In Vivo Study

2017 ◽  
Vol 12 (02) ◽  
pp. 23-29 ◽  
Author(s):  
Thanaa M. Borg ◽  
Elham A. Mohamed ◽  
Eman E. El Naggar ◽  
Ahmad R. Elsheakh
Keyword(s):  
Ulcerative Colitis ◽  
In Vivo Study ◽  
Colon Targeting

In vitro and in vivo study of a colon-targeting pH-sensitive hydrocortisone sodium succinate hydrogel

RSC Advances ◽  
2015 ◽  
Vol 5 (98) ◽  
pp. 80625-80633 ◽  
Author(s):  
Ke Wang ◽  
Kai Dong ◽  
Yan Yan ◽  
Wei Xu ◽  
Lu Zhang ◽  
...  
Keyword(s):  
Sodium Succinate ◽  
Ph Sensitive ◽  
In Vivo Study ◽  
Colon Targeting

The aim of this study was to prepare and characterize a novel pH-sensitive hydrocortisone sodium succinate loaded hydrogel (HSS-GEL) for specifically delivering HSS to the colon, and evaluate its targeting properties.

Formulation and Evaluation of Atorvastatin Calcium-Poly-ε-Caprolactone Nanoparticles Loaded Ocular Inserts for Sustained Release and Antiinflammatory Efficacy

2020 ◽  
Vol 21 (15) ◽  
pp. 1688-1698
Author(s):  
Germeen N.S. Girgis
Keyword(s):  
Sustained Release ◽  
In Vitro Release ◽  
Pluronic F127 ◽  
In Vivo Study ◽  
Average Weight ◽  
Drug Release Profile ◽  
Atorvastatin Calcium ◽  
Anti Inflammatory

Purpose: The work was performed to investigate the feasibility of preparing ocular inserts loaded with Poly-ε-Caprolactone (PCL) nanoparticles as a sustained ocular delivery system. Methods: First, Atorvastatin Calcium-Poly-ε-Caprolactone (ATC-PCL) nanoparticles were prepared and characterized. Then, the optimized nanoparticles were loaded within inserts formulated with Methylcellulose (MC) and Polyvinyl Alcohol (PVA) by a solvent casting technique and evaluated physically, for in-vitro drug release profile. Finally, an in-vivo study was performed on the selected formulation to prove non-irritability and sustained ocular anti-inflammatory efficacy compared with free drug-loaded ocuserts. Results: The results revealed (ATC-PCL) nanoparticles prepared with 0.5% pluronic F127 were optimized with 181.72±3.6 nm particle size, 0.12±0.02 (PDI) analysis, -27.4± 0.69 mV zeta potential and 62.41%±4.7% entrapment efficiency. Nanoparticles loaded ocuserts manifested compatibility between drug and formulation polymers. Moreover, formulations complied with average weight 0.055±0.002 to 0.143±0.023 mg, and accepted pH. ATC-PCL nanoparticles loaded inserts prepared by 5% MC showed more sustained, prolonged in-vitro release over 24h. In-vivo study emphasized non-irritability, ocular anti-inflammatory effectiveness represented by smaller lid closure scores, and statistically significant lowering in PMN count after 3h. Conclusion: These findings proposed a possibly simple, new and affordable price technique to prepare promising (ATC-PCL) nanoparticles loaded inserts to achieve sustained release with prolonged antiinflammatory efficacy.

Quercetin improve ischemia/reperfusion‐induced cardiomyocyte apoptosis in vitro and in vivo study via SIRT1/PGC‐1α signaling

2019 ◽  
Vol 120 (6) ◽  
pp. 9747-9757 ◽  
Author(s):  
Jiayou Tang ◽  
Linhe Lu ◽  
Yang Liu ◽  
Jipeng Ma ◽  
Lifang Yang ◽  
...  
Keyword(s):  
Ischemia Reperfusion ◽  
Cardiomyocyte Apoptosis ◽  
In Vivo Study
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