A domino green method for the rapid synthesis of novel fused isoquinoline derivatives via Knoevenagel/Michael/cyclization reactions on aqueous media and their photophysical properties

RSC Advances ◽  
2015 ◽  
Vol 5 (116) ◽  
pp. 95539-95544 ◽  
Author(s):  
Nandigama Satish Kumar ◽  
L. Chandrasekhara Rao ◽  
N. Jagadeesh Babu ◽  
H. M. Meshram
Keyword(s):  
Photophysical Properties ◽  
Aqueous Media ◽  
Cyclization Reactions ◽  
Rapid Synthesis ◽  
Green Method ◽  
One Pot ◽  
Green Protocol ◽  
Catalyst Free ◽  
Isoquinoline Derivatives

An expedient, eco-friendly and green-protocol has been developed for the synthesis of novel 4-imino-2-aryl-4H-pyrido[2,1-a]isoquinoline-3-carbonitrile derivatives via Knoevenagel/Michael/cyclisation reactions in one pot under catalyst-free conditions on aqueous media.

scholarly journals Sulfur Versus Nitrogen Chelation in C-H Activation: Cobalt(III)-Catalyzed Unsymmetrical Double Annulation of Thioamides

2021 ◽  
Author(s):  
Majji Shankar ◽  
Arijit Saha ◽  
Somratan Sau ◽  
Arghadip Ghosh ◽  
Vincent Gandon ◽  
...  
Keyword(s):  
Density Functional ◽  
Chemical Space ◽  
Photophysical Properties ◽  
Structural Diversity ◽  
One Pot ◽  
Functional Theory ◽  
Biologically Relevant ◽  
Drug Candidates ◽  
Isoquinoline Derivatives ◽  
First Time

An unconventional cobalt(III)-catalyzed one-pot domino double annulation of aryl thioamides with unactivated alkynes is presented. Sulfur (S), nitrogen (N), and o,o'-C-H bonds of aryl thioamides are involved in this reaction, enabling access to rare 6,6-fused thiopyrano-isoquinoline derivatives. A reverse ‘S’ coordination over more conventional ‘N’ coordination of thioamides to Co-catalyst specifically regulates the formation of four [C-C and C-S at first and then C-N and C-C] bonds in a single operation, a concept which is uncovered for the first time. The power of the N-masked methyl phenyl sulfoximine (MPS) directing group in this annulation sequence is established. The transformation is successfully developed, building a novel chemical space of structural diversity (56 examples). In addition, late-stage annulation of biologically relevant motifs and drug candidates are disclosed (17 examples). Preliminary photophysical properties of thiopyrano-isoquinoline derivatives are discussed. Density functional theory (DFT) studies authenticate the participation of a unique 6p-electrocyclization of a 7-membered S-chelated cobaltacycle in the annulation process.<br>

scholarly journals A Facile and Catalyst-Free Microwave-Promoted Multicomponent Reaction for the Synthesis of Functionalised 1,4-Dihydropyridines With Superb Selectivity and Yields

2021 ◽  
Vol 9 ◽  
Author(s):  
Nagaraju Kerru ◽  
Suresh Maddila ◽  
Sreekantha B. Jonnalagadda
Keyword(s):  
Spectroscopic Analysis ◽  
High Selectivity ◽  
Water Medium ◽  
One Pot ◽  
Green Protocol ◽  
Catalyst Free ◽  
Active Methylene Compounds ◽  
The One ◽  
Pyrimidine Analogs ◽  
Active Methylene

We report a highly efficient green protocol for developing a novel library of 1,2,4-triazole-tagged 1,4-dihydropyridine analogs through the one-pot process from the four-component fusion of the 1H-1,2,4-triazol-3-amine with different chosen aldehydes, diethyl acetylenedicarboxylate, and active methylene compounds in a water medium under microwave irradiation and catalyst-free conditions. Excellent yields (94–97%) of the target products were achieved with high selectivity with a short reaction time (&lt;12 min) at room temperature. The structures of the synthesized pyrimidine analogs were established by NMR and HRMS spectroscopic analysis. Simple workup, impressive yields, no column chromatography, green solvent, rapid reaction, and excellent functional group tolerance are the benefits of this protocol.

Aqueous phase one-pot green synthesis of SnSe nanosheets in a protein matrix: negligible cytotoxicity and room temperature emission in the visible region

RSC Advances ◽  
2015 ◽  
Vol 5 (75) ◽  
pp. 61390-61397 ◽  
Author(s):  
Laboni Das ◽  
Apurav Guleria ◽  
Soumyakanti Adhikari
Keyword(s):  
Cyclic Voltammetry ◽  
Green Synthesis ◽  
Cho Cells ◽  
Room Temperature ◽  
Aqueous Media ◽  
Visible Region ◽  
Protein Matrix ◽  
Green Method ◽  
One Pot ◽  
Thermodynamic Feasibility

A rapid, facile, reproducible and green method for synthesizing SnSe nanosheets in aqueous media is reported. Cyclic voltammetry studies indicate better thermodynamic feasibility for reducing SnSe, while the nanomaterial is nontoxic up to a 100 μM concentration in CHO cells.

Multicomponent Reactions of Indoles with 1-Amino-5-aroyl-4-aryl-1H-Pyrimidin-2-ones / -thiones: One-pot three component synthesis of novel Gramine Analogues

2020 ◽  
Vol 17 ◽  
Author(s):  
Hava Aydın ◽  
Elif Korkusuz ◽  
İsmail Yıldırım
Keyword(s):  
Aromatic Aldehyde ◽  
13C Nmr ◽  
Multicomponent Reactions ◽  
Green Method ◽  
One Pot ◽  
1H And 13C Nmr ◽  
Spectroscopic Measurements ◽  
Catalyst Free ◽  
Elemental Analyses ◽  
Ft Ir

: A one-pot three component synthesis of a series of new gramine derivatives was designed and achieved via reactions of indole or N-methylindole with aromatic aldehyde and heteroaryl amines at 80-110 oC for 10-24 hours in an oven under solvent- and catalyst-free conditions provides an efficient, convenient and green method for the syntheses of a series of indol-3-yl- and N-methylindol-3-yl-1-aminopyrimidin-2-ones/thiones. So, fourteen novel gramine derivatives were conveniently synthesized, and characterized by elemental analyses, FT IR, 1H and 13C NMR spectroscopic measurements.

One-pot synthesis of α-iodoketones from alcohols using ammonium iodide and Oxone® in water

RSC Advances ◽  
2015 ◽  
Vol 5 (16) ◽  
pp. 12186-12190 ◽  
Author(s):  
Marri Mahender Reddy ◽  
Peraka Swamy ◽  
Mameda Naresh ◽  
Kodumuri Srujana ◽  
Chevella Durgaiah ◽  
...  
Keyword(s):  
Aqueous Media ◽  
Secondary Alcohols ◽  
Ammonium Iodide ◽  
One Pot ◽  
Green Protocol ◽  
One Pot Synthesis

A novel and green protocol for the synthesis of α-iodoketones from various secondary alcohols in aqueous media is reported.

scholarly journals Transition metal- and catalyst-free one-pot green method for the synthesis of N-sulfonyl amidines via direct reaction of sulfonyl azides with amines

RSC Advances ◽  
2020 ◽  
Vol 10 (45) ◽  
pp. 26701-26708
Author(s):  
Babak Kaboudin ◽  
Saeed Torabi ◽  
Foad Kazemi ◽  
Hiroshi Aoyama
Keyword(s):  
Transition Metal ◽  
Green Synthesis ◽  
Secondary Amines ◽  
Direct Reaction ◽  
Green Method ◽  
One Pot ◽  
Catalyst Free ◽  
Sulfonyl Azides

A green synthesis of N-sulfonyl amidines via the direct reaction of tertiary or secondary amines with sulfonyl azides.

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